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1001020-13-8

1001020-13-8

Identification

Synonyms:3-(trifluoroMethyl)-1H-Pyrazole-4-Methanol;(3-TrifluoroMethyl-1H-pyrazol-4-yl)Methanol;4-(HydroxyMethyl)-3-(TrifluoroMethyl)pyrazole;[5-(trifluoromethyl)-1H-pyrazol-4-yl]methanol

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

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  • Manufacture/Brand:TRC
  • Product Description:(3-Trifluoromethyl-1H-pyrazol-4-yl)methanol
  • Packaging:50mg
  • Price:$ 90
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:(3-Trifluoromethyl-1H-pyrazol-4-yl)methanol 95+%
  • Packaging:250mg
  • Price:$ 490
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:(3-Trifluoromethyl-1H-pyrazol-4-yl)methanol 95+%
  • Packaging:1g
  • Price:$ 1224
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  • Manufacture/Brand:Crysdot
  • Product Description:(3-Trifluoromethyl-1H-pyrazol-4-yl)methanol 97%
  • Packaging:1g
  • Price:$ 211
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:(3-Trifluoromethyl-1H-pyrazol-4-yl)methanol 95+%
  • Packaging:1g
  • Price:$ 240
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:(3-Trifluoromethyl-1H-pyrazol-4-yl)methanol 95+%
  • Packaging:250mg
  • Price:$ 83
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:(3-Trifluoromethyl-1H-pyrazol-4-yl)methanol 95+%
  • Packaging:100mg
  • Price:$ 63
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  • Manufacture/Brand:Chemcia Scientific
  • Product Description:(5-Trifluoromethyl-1H-pyrazol-4-yl)-methanol 95%
  • Packaging:5 G
  • Price:$ 750
  • Delivery:In stock
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  • Manufacture/Brand:Atlantic Research Chemicals
  • Product Description:(3-Trifluoromethyl-1H-pyrazol-4-yl)methanol 95%
  • Packaging:1gm:
  • Price:$ 378.2
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:(3-TRIFLUOROMETHYL-1H-PYRAZOL-4-YL)METHANOL 95.00%
  • Packaging:5MG
  • Price:$ 496.95
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Relevant articles and documentsAll total 3 Articles be found

SUBSTITUTED BICYCLE HETEROCYCLIC DERIVATIVES USEFUL AS ROMK CHANNEL INHIBITORS

-

Page/Page column 173; 174, (2018/06/06)

Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is (II) or (III); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3, L1, L2, R1a, R1b, R1c, and n are define herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

PYRAZOLEALKANAMIDE SUBSTITUTED THIOPHENES AS AMPA POTENTIATORS

-

Page/Page column 52-53, (2008/06/13)

The present invention relates to a heterocyclic derivative according to Formula (I) wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to a pharmaceuti

Process route upstream and downstream products

Process route

ethyl 3-trifluoromethyl-1H-pyrazole-4-carboxylate
155377-19-8

ethyl 3-trifluoromethyl-1H-pyrazole-4-carboxylate

(3-(trifluoromethyl)-1H-pyrazolyl-4-yl)methanol
1001020-13-8

(3-(trifluoromethyl)-1H-pyrazolyl-4-yl)methanol

Conditions
Conditions Yield
ethyl 3-trifluoromethyl-1H-pyrazole-4-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 10 - 20 ℃; for 4.5h; Cooling with acetone/ice bath;
With hydrogenchloride; water; at 20 ℃; pH=6;
100%
ethyl 3-trifluoromethyl-1H-pyrazole-4-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 3h;
With methanol; In tetrahydrofuran; for 0.5h;
53%
With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 - 20 ℃; for 4.5h;
50.1%
(3-(trifluoromethyl)-1H-pyrazolyl-4-yl)methanol
1001020-13-8

(3-(trifluoromethyl)-1H-pyrazolyl-4-yl)methanol

(S)-benzyl 5-(chloromethyl)-2,3-dihydro-1H-inden-2-ylcarbamate

(S)-benzyl 5-(chloromethyl)-2,3-dihydro-1H-inden-2-ylcarbamate

(R)-benzyl-5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-2-ylcarbamate
1199827-82-1

(R)-benzyl-5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-2-ylcarbamate

Conditions
Conditions Yield
With potassium carbonate; at 60 ℃;
With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 1h;
(3-(trifluoromethyl)-1H-pyrazolyl-4-yl)methanol
1001020-13-8

(3-(trifluoromethyl)-1H-pyrazolyl-4-yl)methanol

(S)-benzyl 5-(hydroxymethyl)-2,3-dihydro-1H-inden-2-ylcarbamate
1199828-07-3

(S)-benzyl 5-(hydroxymethyl)-2,3-dihydro-1H-inden-2-ylcarbamate

(S)-benzyl-5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-2-ylcarbamate
1199828-09-5

(S)-benzyl-5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-2-ylcarbamate

Conditions
Conditions Yield
With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 1h;
(3-(trifluoromethyl)-1H-pyrazolyl-4-yl)methanol
1001020-13-8

(3-(trifluoromethyl)-1H-pyrazolyl-4-yl)methanol

C<sub>18</sub>H<sub>18</sub>ClNO<sub>2</sub>
1251457-90-5

C18H18ClNO2

(S)-benzyl-5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-2-ylcarbamate
1199828-09-5

(S)-benzyl-5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-2-ylcarbamate

Conditions
Conditions Yield
With potassium carbonate; at 60 ℃;
(3-(trifluoromethyl)-1H-pyrazolyl-4-yl)methanol
1001020-13-8

(3-(trifluoromethyl)-1H-pyrazolyl-4-yl)methanol

3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde
1001020-14-9

3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde

Conditions
Conditions Yield
With manganese(IV) oxide; In toluene; for 5.5h; Molecular sieve; Reflux;
100%
With manganese(IV) oxide; In acetonitrile; at 120 ℃; for 0.0833333h; Microwave irradiation;
34%

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