155377-19-8

Basic information

• Product Name: ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE
• Synonyms: BUTTPARK 29\06-81;ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE;ETHYL 3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE;3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLIC ACID, ETHYL ESTER;ETHYL 3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-;Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate 97%;Ethyl3-(trifluoromethyl)pyrazole-4-carboxylate97%;Ethyl 3-(trifluoromethyl)pyrazole-4-c
• CAS NO: 155377-19-8
• Molecular Formula: C₇H₇F₃N₂O₂
• Molecular Weight: 208.14
• Product Categories: Nucleotides and Nucleosides;Bases & Related Reagents;Nucleotides;Esters;Pyrazoles & Triazoles;Building Blocks;Heterocyclic Building Blocks;Pyrazoles
• Mol File: 155377-19-8.mol
• Article Data: 20

Chemical Properties

• Melting Point: 145 °C
• Boiling Point: 301.3 °C at 760 mmHg
• Flash Point: 136 °C
• Appearance: /
• Density: 1.397 g/cm³
• Vapor Pressure: 0.00781mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: soluble in Methanol
• PKA: 8.26±0.50(Predicted)
• CAS DataBase Reference: ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE(155377-19-8)
• EPA Substance Registry System: ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE(155377-19-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 155377-19-8(Hazardous Substances Data)

Usage

Chemical Properties

White to tan powder

Uses

Ethyl 3-(Trifluoromethyl)pyrazole-4-carboxylate (cas# 155377-19-8) is a compound useful in organic synthesis.

InChI:InChI=1/C7H5F3IN/c8-7(9,10)5-3-4(12)1-2-6(5)11/h1-3H,12H2

Upstream product

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Downstream Products

• 741717-63-5 ethyl 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate 
• 543739-84-0 3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid 
• 142818-01-7 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid 
• 543739-84-0 5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid 
• 338959-51-6 ethyl 1-(4-cyanophenyl)-3-trifluoromethylpyrazole-4-carboxylate 
• 19968-19-5 3,4-Bis-(trifluormethyl)-pyrazol 
• 477709-06-1 1-methyl-N-(4-methylpyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide 
• 1421917-34-1 N-(pyridin-4-yl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide 
• 1421917-35-2 N-(2-chloropyridin-4-yl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide 
• 1421917-36-3 N-(2-bromopyridin-4-yl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide 
• 1421917-37-4 N-(pyridin-2-yl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide 
• 1421917-38-5 N-(3-chloropyridin-4-yl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide 
• 1421917-39-6 N-(3-bromopyridin-4-yl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide 
• 1421917-40-9 N-(3-methylpyridin-4-yl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide 

Relevant articles and documents

"Reported, but still unknown." A closer look into 3,4-bis- and 3,4,5-tris(trifluoromethyl)pyrazoles

Straightforward practical synthetic approaches to 3,4-bis- and 3,4,5-tris(trifluoromethyl)pyrazoles have been developed. The key step of the both syntheses is a transformation of the carboxylic group in a pyrazole core into the trifluoromethyl group by sulfur tetrafluoride. The elaborated synthetic protocols allow gram-scale preparation of the target products. The obtained compounds are comprehensively characterized by means of crystallographic analysis, determination of pKa values and fluorescence measurements.

Preparation method for polyhalogenated methylpyrazole formate

The invention discloses a preparation method for polyhalogenated methylpyrazole formate. The preparation method comprises the following specific steps: with a compound with a chemical structural formula I which is described in the specification and formyl acetate sodium salt as raw materials, subjecting the compound and the formyl acetate sodium salt to a low-temperature reaction in an organic solvent for 0.5-4 h under the action of a quaternary ammonium salt catalyst, then adding substituted hydrazine, and carrying out a cyclization reaction for 0.5-4 h so as to generate the polyhalogenated methylpyrazole formate as shown in a formula II which is described in the specification. The preparation method provided by the invention has the advantages of safe and easily-controllable process, mild synthesis condition, high atom economy, low emission of three wastes and good industrial value.

A new method for making pyrazole or pyrimidinone

The invention relates to the use of an amine compound in a method for producing a fluorinated or non-fluorinated 5- or 6-membered heterocyclic compound (preferably pyrazole or pyrimidinone) containingtwo nitrogen atoms in a ring system. The invention also relates to a method for producing a pyrazole or pyrimidinone, which may be fluorinated or may not be fluorinated (non-fluorinated). Each of thefluorinated pyrazole or fluorinated pyrimidinone is a very important structural unit for pharmaceutical and agricultural applications. For example, fungicides are strongly dependent on bifenapram, fluoxastrobin, flubenazolid, fluoxastrobin, pyraclostrobin, and pyracloprid, each with this fluorinated pyrazole as a key structural unit, and benflufenazole respectively, or diflufenacil and chlorfensulfazone (dimethachlor).