1001067-09-9 Usage
Physical properties
Mp (dec.) 85–86 °C.
Uses
2-(Trimethylsilyl)ethoxycarbonyl
(Teoc) group is one of the most useful protecting groups for amines, which can be cleaved by fluoride ion under neutral conditions. However, 2-(trimethylsilyl)ethyl chloroformate(Teoc-Cl), which is generally used for the introduction of the Teoc protecting group in amines, is quite unstable and easy to decompose; therefore, distillation is recommended at regular
intervals. On the other hand, Teoc-NT is a highly stable, nonhygroscopic crystalline material and can be stored for long periods without decomposition. Generally, carbamate formation proceeds quickly under neutral conditions, and highly pure carbamates are obtained without tedious column chromatographic
purification. Furthermore, the coproduct 3-nitro-1,2,4-triazole (NT) can be recycled. It participates in the reactions of Reactions with Amines and Aminoalcohols, Amine Protection for Nucleosides, Reaction with Alcohols, etc.
Check Digit Verification of cas no
The CAS Registry Mumber 1001067-09-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,1,0,6 and 7 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1001067-09:
(9*1)+(8*0)+(7*0)+(6*1)+(5*0)+(4*6)+(3*7)+(2*0)+(1*9)=69
69 % 10 = 9
So 1001067-09-9 is a valid CAS Registry Number.
1001067-09-9Relevant articles and documents
Development of column-free alkoxycarbonyl, aryloxycarbonyl, and acyl transfer reagents
Shimizu, Mamoru,Sodeoka, Mikiko
experimental part, p. 1301 - 1312 (2009/07/05)
Easy-to-handle alkoxycarbonyl, aryloxycarbonyl, and acyl transfer reagents, which contain 3-nitro-1,2,4-triazole (NT) as a leaving group, were developed. With these reagents (NT reagents), which are stable nonhygroscopic crystalline materials, the reactions can be accomplished in about 5 min, and product can be isolated without tedious column chromatographic purification.
