1001327-35-0

Basic information

• Product Name: C₁₇H₂₂O₃S
• Synonyms: C₁₇H₂₂O₃S
• CAS NO: 1001327-35-0
• Molecular Weight: 306.426
• Mol File: 1001327-35-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: C₁₇H₂₂O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₂₂O₃S(1001327-35-0)
• EPA Substance Registry System: C₁₇H₂₂O₃S(1001327-35-0)

Safety Data

• Hazardous Substances Data: 1001327-35-0(Hazardous Substances Data)

Upstream product

• 1207106-17-9 (E)-2-(4-(cyclopropylthio)phenyl)-3-(tetrahydro-2H-pyran-4-yl)acrylic acid 

Downstream Products

• 745053-49-0 (R)-2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)propanoic acid 

Relevant articles and documents

An asymmetric synthesis of a chiral sulfone acid with concomitant hydrolysis and oxidation to enable the preparation of a glucokinase activator

This contribution describes the demonstration of an asymmetric synthesis of a glucokinase activator via protonation of the enolate generated from an alkylaryl ketene and (R)-pantolactone. Additionally, a one-pot hydrolysis/oxidation protocol with lithium hydroperoxide was developed to afford a chiral sulfone acid without degradation of the labile stereocenter.

NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME

Compounds are provided which are glucokinase activators and thus are useful in treating diabetes and related diseases and have the structure wherein in the ring represents one or two double bonds; R1 is aryl or heteroaryl; R2 is halogen, cycloalkyl, heterocyclyl, aryl, or heteroaryl; R5 is as defined herein; Z is O, S, S(O), S(O)2, or NR5a; X is S, O, N, NR3, or CR3; Y is NCR4 or N4; R3, R4, and R5 are as defined herein; R8 is aryl or heteroaryl; R6 and R7 are independently H, halogen, or alkyl; m is 0 or 1; and n is 0 to 3, or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.