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CAS

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1002304-34-8

AMG-208, also known as 7-methoxyquinoline, is a member of the quinolines class that features a (6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy group substitution at position 4. It is a pharmaceutical compound with significant antitumor activity, particularly in prostate cancer.

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  • 1002304-34-8 Structure

  • Basic information

    1. Product Name: AMG-208
    2. Synonyms: AMG-208;7-Methoxy-4-[(6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline;Quinoline, 7-Methoxy-4-[(6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)Methoxy]-;7-Methoxy-4-[(6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline AMG 208;AMG-208, >=98%
    3. CAS NO:1002304-34-8
    4. Molecular Formula: C22H17N5O2
    5. Molecular Weight: 383.41
    6. EINECS: N/A
    7. Product Categories: Inhibitors
    8. Mol File: 1002304-34-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.34
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: insoluble in EtOH; insoluble in H2O; ≥3.83 mg/mL in DMSO
    9. PKA: 5.98±0.27(Predicted)
    10. CAS DataBase Reference: AMG-208(CAS DataBase Reference)
    11. NIST Chemistry Reference: AMG-208(1002304-34-8)
    12. EPA Substance Registry System: AMG-208(1002304-34-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1002304-34-8(Hazardous Substances Data)

1002304-34-8 Usage

Uses

Used in Pharmaceutical Industry:
AMG-208 is used as an antitumor agent for its ability to target and combat prostate cancer. It has demonstrated potential in inhibiting tumor growth and progression, making it a promising candidate for cancer treatment.
Used in Cancer Research:
In the field of cancer research, AMG-208 is utilized as a subject of study to better understand its mechanisms of action and potential applications in treating various types of cancer. Its unique chemical structure and antitumor properties make it an interesting compound for further investigation and development.

Check Digit Verification of cas no

The CAS Registry Mumber 1002304-34-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,2,3,0 and 4 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1002304-34:
(9*1)+(8*0)+(7*0)+(6*2)+(5*3)+(4*0)+(3*4)+(2*3)+(1*4)=58
58 % 10 = 8
So 1002304-34-8 is a valid CAS Registry Number.
InChI:InChI=1S/C22H17N5O2/c1-28-16-7-8-17-19(13-16)23-12-11-20(17)29-14-22-25-24-21-10-9-18(26-27(21)22)15-5-3-2-4-6-15/h2-13H,14H2,1H3

1002304-34-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-methoxy-4-[(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline

1.2 Other means of identification

Product number -
Other names 7-methoxy-4-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)quinoline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1002304-34-8 SDS

1002304-34-8Downstream Products

1002304-34-8Relevant articles and documents

Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase

Albrecht, Brian K.,Harmange, Jean-Christophe,Bauer, David,Berry, Loren,Bode, Christiane,Boezio, Alessandro A.,Chen, April,Choquette, Deborah,Dussault, Isabelle,Fridrich, Cary,Hirai, Satoko,Hoffman, Doug,Larrow, Jay F.,Kaplan-Lefko, Paula,Lin, Jasmine,Lohman, Julia,Long, Alexander M.,Moriguchi, Jodi,O'Connor, Anne,Potashman, Michele H.,Reese, Monica,Rex, Karen,Siegmund, Aaron,Shah, Kavita,Shimanovich, Roman,Springer, Stephanie K.,Teffera, Yohannes,Yang, Yajing,Zhang, Yihong,Bellon, Steven F.

supporting information; experimental part, p. 2879 - 2882 (2009/05/30)

Tumorigenesis is a multistep process in which oncogenes play a key role in tumor formation, growth, and maintenance. MET was discovered as an oncogene that is activated by its ligand, hepatocyte growth factor. Deregulated signaling in the c-Met pathway ha

FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE

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Page/Page column 182, (2010/11/29)

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

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