Welcome to LookChem.com Sign In|Join Free

CAS

  • or
S)-2-broMo-1-(4-broMophenyl)ethanol is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

100306-24-9 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 100306-24-9 Structure
  • Basic information

    1. Product Name: S)-2-broMo-1-(4-broMophenyl)ethanol
    2. Synonyms: S)-2-broMo-1-(4-broMophenyl)ethanol
    3. CAS NO:100306-24-9
    4. Molecular Formula: C8H8Br2O
    5. Molecular Weight: 279.95652
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 100306-24-9.mol
  • Chemical Properties

    1. Melting Point: 69-71 °C
    2. Boiling Point: 334.2±27.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.868±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 12.80±0.20(Predicted)
    10. CAS DataBase Reference: S)-2-broMo-1-(4-broMophenyl)ethanol(CAS DataBase Reference)
    11. NIST Chemistry Reference: S)-2-broMo-1-(4-broMophenyl)ethanol(100306-24-9)
    12. EPA Substance Registry System: S)-2-broMo-1-(4-broMophenyl)ethanol(100306-24-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 100306-24-9(Hazardous Substances Data)

100306-24-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 100306-24-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,3,0 and 6 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 100306-24:
(8*1)+(7*0)+(6*0)+(5*3)+(4*0)+(3*6)+(2*2)+(1*4)=49
49 % 10 = 9
So 100306-24-9 is a valid CAS Registry Number.

100306-24-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-2-bromo-1-(4-bromophenyl)ethanol

1.2 Other means of identification

Product number -
Other names (2S)-2-bromo-1-(4-bromophenyl)ethanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:100306-24-9 SDS

100306-24-9Relevant articles and documents

(5S)-1,3-Diaza-2-imino-3-phenylbicyclo[3.3.0]octane: first example of guanidine based in situ recyclable chiral catalytic source for borane-mediated asymmetric reduction of prochiral ketones

Basavaiah, Deevi,Venkateswara Rao, Kalapala,Sekhara Reddy, Bhavanam

, p. 1036 - 1040 (2006)

(5S)-1,3-Diaza-2-imino-3-phenylbicyclo[3.3.0]octane has been synthesized and successfully employed, for the first time, as a chiral catalytic source for the borane-mediated asymmetric reduction of prochiral α-halo ketones to provide the corresponding secondary alcohols in high enantiomeric purity. The potential of this guanidine as an in situ recyclable chiral catalytic source for the borane-mediated chiral reduction processes has also been demonstrated.

Enantioselective reduction of ketones with "designer cells" at high substrate concentrations: Highly efficient access to functionalized optically active alcohols

Groeger, Harald,Chamouleau, Francoise,Orologas, Nicolas,Rollmann, Claudia,Drauz, Karlheinz,Hummel, Werner,Weckbecker, Andrea,May, Oliver

, p. 5677 - 5681 (2006)

(Chemical Equation Presented) Productive cells: In a simple, highly efficient process for the synthesis of optically active alcohols, ketones are reduced by "designer cells" at high substrate concentrations and without the addition of an "external" cofactor in aqueous reaction medium. A wide range of R and S alcohols can be prepared with conversions of > 90% and enantioselectivities of > 99% ee (scheme shows results from the application on a 10-L scale).

Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase

Maetani, Micah,Kato, Nobutaka,Jabor, Valquiria A. P.,Calil, Felipe A.,Nonato, Maria Cristina,Scherer, Christina A.,Schreiber, Stuart L.

, p. 438 - 442 (2017)

Dihydroorotate dehydrogenase (DHODH) is an enzyme necessary for pyrimidine biosynthesis in protozoan parasites of the genus Plasmodium, the causative agents of malaria. We recently reported the identification of novel compounds derived from diversity-oriented synthesis with activity in multiple stages of the malaria parasite life cycle. Here, we report the optimization of a potent series of antimalarial inhibitors consisting of azetidine-2-carbonitriles, which we had previously shown to target P. falciparum DHODH in a biochemical assay. Optimized compound BRD9185 (27) has in vitro activity against multidrug-resistant blood-stage parasites (EC50 = 0.016 μM) and is curative after just three doses in a P. berghei mouse model. BRD9185 has a long half-life (15 h) and low clearance in mice and represents a new structural class of DHODH inhibitors with potential as antimalarial drugs.

Toward effective chiral catalysts containing the N-P=O structural framework for the borane-mediated asymmetric reduction of prochiral ketones

Basavaiah, Deevi,Reddy, Gone Jayapal,Rao, Kalapala Venkateswara

, p. 1881 - 1888 (2004)

Representative chiral catalysts containing the N-P=O structural framework having (5S)-1,3-diaza-2-phospha-2-oxo-3-phenylbicyclo[3.3.0]octane moiety with amino groups of varying steric requirements on phosphorus, have been synthesized and their applications in the borane-mediated asymmetric reduction of prochiral ketones described.

(5S)-1-Aza-2-imino-3-oxa-4,4-diphenylbicyclo(3.3.0)octane: a novel chiral catalytic source containing the N-(C{double bond, long}NH)-O moiety for the borane-mediated asymmetric reduction of prochiral ketones

Basavaiah, Deevi,Venkateswara Rao, Kalapala,Sekhara Reddy, Bhavanam

, p. 963 - 967 (2007)

(5S)-1-Aza-2-imino-3-oxa-4,4-diphenylbicyclo(3.3.0)octane, a novel chiral catalytic source containing the N-(C{double bond, long}NH)-O moiety, has been synthesized and successfully utilized, for the first time, as a chiral catalytic source in the borane-mediated asymmetric reduction of prochiral ketones in refluxing toluene, to provide the corresponding secondary alcohols with up to 93% enantiomeric excess.

Immobilization of Amano lipase from Pseudomonas fluorescens on silk fibroin spheres: an alternative protocol for the enantioselective synthesis of halohydrins

Ferreira, Irlon M.,Yoshioka, Sergio A.,Comasseto, Jo?o V.,Porto, André L. M.

, p. 12650 - 12658 (2017)

The search for a new, efficient, cheaper and sustainable matrix for lipase immobilization is a growing area in biotechnology. Amano lipase from Pseudomonas fluorescens was immobilized on silk fibroin spheres and used in the enzymatic kinetic resolution of halohydrins, to obtain optically active epoxides (up to 99% ee), important precursors in the synthesis of derivative antifungal azoles. This paper reinforces the versatility of silk fibroin as a support for heterogeneous catalysts.

cis-1-Amino-2-indanol in asymmetric synthesis. Part I. A practical catalyst system for the enantioselective borane reduction of aromatic ketones

Hong, Yaping,Gao, Yun,Nie, Xiaoyi,Zepp, Charles M.

, p. 6631 - 6634 (1994)

A new class of oxazaborolidine catalysts has been prepared from optically pure cis-1-amino-2 indanols which are available in large quantities. The asymmetric borane reduction of aromatic ketones using these catalysts has been studied.

Selective Reductions. 37. Asymmetric Reduction of Prochiral Ketones with B-(3-Pinanyl)-9-borabicyclononane

Brown, Herbert C.,Pai, G. Ganesh

, p. 1384 - 1394 (1985)

The chiral trialkylborane B-(3-pinanyl)-9-borabicyclononane, either with the neat reagents or concentrated solutions, 2 M, reduces a wide range of prochiral carbonyl compounds with good to excellent asymmetric induction.Reduction of simple dialkyl ketones, 2-butanone, 2-octanone, 3-methyl-2-butanone, and 3,3-dimethyl-2-butanone, yields the corresponding alcohols with 43percent, 48percent, 62percent, and 0.7percent asymmetric induction.Acetophenone is reduced to 1-phenylethanol in 85percent ee.The α,β-unsaturated ketones 3-buten-2-one, 1-acetyl-1-cyclohexene, 3-methyl-2-cyclohexenone, and trans-4-phenyl-3-buten-2-one are reduced to the corresponding allylic alcohols with 57percent, 64percent, 11percent, and 97percent asymmetric induction, respecticvely.The α,β-conjugated acetylenic ketones 3-butyn-2-one, 4-methyl-1-pentyn-3-one, and 4-phenyl-3-butyn-2-one underwent a rapid reduction to afford the corresponding propargylic alcohols with 79percent, 99percent, and 91percent enantiomeric purities.The α-haloalkyl aromatic ketones α-chloroacetophenone, α-bromoacetophenone, α-iodoacetophenone, α,p-dibromoacetophenone, α-bromo-p-cyanoacetophenone,α-bromo-2'-acetonaphthone,and α,α,α-trifluoroacetophenone afforded the corresponding halohydrins with 96percent,93percent,93percent,96percent,96percent,90percent,and35percent enantiomeric purities, respectively.The corresponding aliphatic analogue 1-bromo-3-methyl-butanone gave the halohydrin in 66percent ee.The other isomer of this ketone, 3-bromo-3-methyl-2-butanone, failed to undergo reduction.Both the aliphatic and aromatic α-keto esters underwent rapid reduction to give the corresponding α-hydroxy esters with excellentenantiomeric excesses.Thus, methyl, ethyl, isopropyl, and tert-butyl pyruvates afforded the corresponding lactates with 86percent,83percent,78percent, and 92percent ee at 25 deg C,respectively.Lowering the reaction temperature to 0 deg C gave the tert-butyl lactate in 100percent ee.Other aliphatic α-keto esters such as metyl and ethyl 2-oxopentanoates, methyl 3-methyl-2-oxobutanoate, and ethyl 4-methyl-2-oxopentanoate were reduced to the corresponding α-hydroxy esters with 96percent, 96percent, 11percent, and 82percent ee.The methyl, isopropyl, and tert-butyl benzoylformates were reduced to the corresponding mendelic esters with 90percent, 96percent and 100percent ee, respectively.The reduction of the β-keto esters, however, proceeded slowly and ethyl acetoacetate gave the corresponding alcohol with 55percent ee.

A new chiral catalytic source with an N-P=O structural framework containing a proximal hydroxyl group for the borane-mediated asymmetric reduction of prochiral ketones

Basavaiah, Deevi,Reddy, Gone Jayapal,Chandrashekar, Vanampally

, p. 47 - 52 (2004)

(5S)-2-[(1R,2R,3S,5R)-2-Hydroxy-2,6,6-trimethylbicyclo[3.1.1] heptan-3-yloxy]-1,3-diaza-2-phospha-2-oxo-3-phenylbicyclo[3.3.0]octane has been successfully employed as a novel chiral catalytic source (4mol%) for borane-mediated asymmetric reduction of prochiral ketones thus providing the resulting secondary alcohols with up to 96% enantiomeric excess.

IRAK DEGRADERS AND USES THEREOF

-

Paragraph 00962; 001570-001572, (2020/06/19)

The present invention provides compounds, compositions thereof, and methods of using the same.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 100306-24-9