100367-48-4

Basic information

• Product Name: 5-Amino-2-fluorophenol
• Synonyms: 5-Amino-2-fluorophenol;4-Fluoro-3-hydroxyaniline;5-Amino-2-fluorophenol 95+%
• CAS NO: 100367-48-4
• Molecular Formula: C₆H₆FNO
• Molecular Weight: 127
• Mol File: 100367-48-4.mol

Chemical Properties

• Melting Point: 156-158℃
• Appearance: White to yellow/Solid
• CAS DataBase Reference: 5-Amino-2-fluorophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-2-fluorophenol(100367-48-4)
• EPA Substance Registry System: 5-Amino-2-fluorophenol(100367-48-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 100367-48-4(Hazardous Substances Data)

Usage

Uses

5-Amino-2-fluorophenol is used as synthetic building block.

Upstream product

• 22510-08-3 2-fluoro-5-nitrophenol 
• 64465-53-8 4-fluoro-3-methoxyaniline 

Downstream Products

• 1188906-71-9 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6_,7-dimethoxyquinazolin-4-yloxy)-4-fluorophenyl)urea 

Relevant articles and documents

Sulfur(vi) fluoride exchange as a key reaction for synthesizing biaryl sulfate core derivatives as potent hepatitis C virus NS5A inhibitors and their structure-activity relationship studies

Extremely potent, new hepatitis C virus (HCV) nonstructural 5A (NS5A) featuring substituted biaryl sulfate core structures was designed and synthesized. Based on the previously reported novel HCV NS5A inhibitors featuring biaryl sulfate core structures which exhibit two-digit picomolar half-maximal effective concentration (EC50) values against HCV genotype 1b and 2a, the new inhibitors equipped with the sulfate core structures containing diversely substituted aryl groups were explored. In this study, highly efficient, chemoselective coupling reactions between an arylsulfonyl fluoride and an aryl silyl ether, known as the sulfur(vi) fluoride exchange (SuFEx) reaction, were utilized. Among the inhibitors prepared based on the SuFEx chemistry, compounds 14, 15 and 29 exhibited two-digit picomolar EC50 values against GT-1b and single digit or sub nanomolar activities against the HCV GT-2a strain. Nonsymmetrical inhibitors containing an imidazole and amide moieties on each side of the sulfate core structures were also synthesized. In addition, a biotinylated probe targeting NS5A protein was prepared for labeling using the same synthetic methodology.

Diphenyl sulfate derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and pharmaceutical composition for use in preventing or treating hepatitis C virus related diseases

The present invention relates to a diphenyl sulfate derivative or a pharmaceutically acceptable salt thereof, a production method thereof, and a pharmaceutical composition for preventing or treating hepatitis C virus-associated diseases containing the same as an active ingredient. According to the present invention, the diphenyl sulfate derivative excellently inhibits infection by hepatitis C virus and replication of hepatitis C virus, and thus can be useful as pharmaceutical compositions for preventing or treating liver diseases such as hepatocellular cancer, cirrhosis, chronic hepatitis C, and acute hepatitis C caused by hepatitis C virus.COPYRIGHT KIPO 2017

With tyrosine kinase inhibitory activity of 2 - indolone derivatives and its preparation method and application

The invention discloses a 2-indolone derivative with tyrosine kinase inhibition activity, geometric isomers and medicinal salts thereof, and a preparation method and an application of the above compounds. Tyrosine kinase inhibition activity evaluation confirms that the derivative is a compound with good tyrosine kinase activity, so the derivative has potential antitumor activity, and can be used to prepare tumor disease prevention and treatment medicines (antitumor medicines) as an active component. The derivative provides research and enforcement foundation for tumor treatment, and has a wide application prospect.

TRPV4 ANTAGONISTS

The present invention relates to quinoline analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF

Compounds according to formula (I), compositions and methods are provided for modulating the activity of RAF kinases, including BRAF kinase and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by RAF kinases. Formula (I): or a pharmaceutically acceptable salt, solvate, clathrate of hydrate thereof, wherein X is O or S(O)t; Ra is O or S.

CINNOLINE COMPOUNDS AS INHIBITORS OF PHOSPHODIESTERASE TYPE IV (PDE4)

There are provided according to the invention novel compounds of formula (I).

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