100393-43-9

Basic information

• Product Name: α-phenyl-α-(2-pyridyl-N-oxide)ethanol
• Synonyms: α-phenyl-α-(2-pyridyl-N-oxide)ethanol
• CAS NO: 100393-43-9
• Molecular Weight: 215.252
• Mol File: 100393-43-9.mol

Chemical Properties

• CAS DataBase Reference: α-phenyl-α-(2-pyridyl-N-oxide)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: α-phenyl-α-(2-pyridyl-N-oxide)ethanol(100393-43-9)
• EPA Substance Registry System: α-phenyl-α-(2-pyridyl-N-oxide)ethanol(100393-43-9)

Safety Data

• Hazardous Substances Data: 100393-43-9(Hazardous Substances Data)

Usage

Uses

Used in Coordination Chemistry:
α-phenyl-α-(2-pyridyl-N-oxide)ethanol is employed as a ligand for the formation of coordination compounds and metal complexes. Its pyridine N-oxide group facilitates unique coordination properties, which are essential for the development of new materials with tailored properties.
Used in Chelating Agent Applications:
α-phenyl-α-(2-pyridyl-N-oxide)ethanol is used as a chelating agent, where its ability to form stable complexes with metal ions is crucial. Its use in chelating applications can be beneficial in various fields, such as environmental remediation and the stabilization of metal ions in chemical reactions.
Used in Catalytic Reactions:
α-phenyl-α-(2-pyridyl-N-oxide)ethanol is utilized in catalytic processes, where its reactivity and coordination capabilities can enhance the efficiency of chemical reactions. Its role in catalysis can lead to the development of more sustainable and efficient synthetic pathways.
Used in Organic and Inorganic Chemistry:
α-phenyl-α-(2-pyridyl-N-oxide)ethanol is used as a versatile building block in the synthesis of a wide range of organic and inorganic compounds. Its chemical versatility allows for its incorporation into various molecular structures, contributing to the advancement of chemical research and development.

Upstream product

• 694-59-7 pyridine N-oxide 
• 98-86-2 acetophenone 
• 19490-92-7 1-phenyl-1-(pyridin-2-yl)ethanol 
• 1122-62-9 2-acetylpyridine 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 1217437-09-6 α-(2-pyridyl-N-oxide)styrene 

Relevant articles and documents

Difunctionalization of Alkenylpyridine N-Oxides by the Tandem Addition/Boekelheide Rearrangement

A convenient and efficient approach for the difunctionalization of alkenylpyridine N-oxides through the tandem addition/Boekelheide rearrangement has been developed. The C-O and C-X (S, O, Cl) bonds are constructed simultaneously at the α- and β-positions under mild reaction conditions in 100% atom economy, which complements previously reported α- or β-functionalizations.

Synthesis and crystal structures of α-phenyl- and α-trifluoromethyl-α-(2-pyridyl-N-oxide)ethanols and α-phenyl-α-(2-pyridyl-N-oxide)ethylene

The X-ray structures of two α-substituted α-(2-pyridyl-N-oxide) ethanols, the α-phenyl- (3a) and α-trifluoromethyl- (3b) derivatives, were determined. On dehydration of 3a, compound 4a was obtained. This study brought a clear proof that the α-(2-pyridyl-N-oxide)ethanols are formed following oxidation with peroxides of their corresponding pyridines. A different molecular packing was observed for the α-trifluoromethyl derivative due to an additional hydrogen bonding. Compound 3a crystallized in the monoclinic space group P 21/n with unit cell parameters a = 5.7416(1) A, b = 14.3841(4) A, c = 13.2821(3) A, β = 94.918(2)°, V = 1092.90(4) A3, Z = 4, D = 1.308 Mg/m 3. Compound 3b crystallized in the triclinic space group P -1 with unit cell parameters a = 6.1209(2) A, b = 8.1938(4) A, c = 9.4675(4) A, α = 73.363(3)°, β = 73.166(3)°, γ = 71.659(3)°, V = 421.32(3) A3, Z = 2, D = 1.633 Mg/m 3. Compound 4a crystallized in the monoclinic space group P 2 1/n with unit cell parameters a = 9.3579(3) A, b = 12.7340(3) A, c = 9.8579(3) A, β = 117.3249(15)°, V = 1043.63(5) A3, Z = 4, D = 1.255 Mg/m3.

ELECTROPHILIC REACTION OF PYRIDINE, QUINOLINE, ISOQUINOLINE, THEIR N-OXIDES AND THEIR BORON TRIFLUORIDE COMPLEXES THROUGH BASE-INDUCED DEPROTONATION

The comparative studies have been carried out on reactivities of pyridine, quinoline, isoquinoline, and their BF3 complexes, their N-oxides, and their N-oxide-BF3-complexes, towards the electrophilic reaction through α-deprotonation.