1005-85-2

Basic information

• Product Name: 3,3-PENTAMETHYLENE-2-PYRROLIDINONE
• Synonyms: 3,3-PENTAMETHYLENE-2-PYRROLIDINONE;3-AZASPIRO[5.5]UNDECANE-2,4-DIONE;CAI;2-Azaspiro[4.5]decan-1-one;Carbonate dehydratase I;Carbonic anhydrase 1
• CAS NO: 1005-85-2
• Molecular Formula: C₉H₁₅NO
• Molecular Weight: 153.22
• EINECS: 214-459-1
• Mol File: 1005-85-2.mol

Chemical Properties

• Melting Point: 110 °C
• Boiling Point: 330.144 °C at 760 mmHg
• Flash Point: 192.25 °C
• Appearance: /
• Density: 1.055 g/cm³
• Storage Temp.: -20°C
• PKA: 16.27±0.20(Predicted)
• CAS DataBase Reference: 3,3-PENTAMETHYLENE-2-PYRROLIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-PENTAMETHYLENE-2-PYRROLIDINONE(1005-85-2)
• EPA Substance Registry System: 3,3-PENTAMETHYLENE-2-PYRROLIDINONE(1005-85-2)

Safety Data

• Hazardous Substances Data: 1005-85-2(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
3,3-PENTAMETHYLENE-2-PYRROLIDINONE is used as a solvent and precursor for its ability to facilitate various chemical reactions, enhancing the efficiency and selectivity of organic synthesis processes.
Used in the Production of Polyamide-6:
In the Textile and Plastics Industries, 3,3-PENTAMETHYLENE-2-PYRROLIDINONE is used as a caprolactam surrogate, contributing to the manufacturing of polyamide-6, a key material in these sectors due to its strength, durability, and versatility.
Used in Pharmaceutical Synthesis:
3,3-PENTAMETHYLENE-2-PYRROLIDINONE is utilized as an intermediate in the synthesis of pharmaceuticals, playing a crucial role in the development of new drugs and medicinal compounds.
Used in Agrochemical Production:
In the Agrochemical Industry, 3,3-PENTAMETHYLENE-2-PYRROLIDINONE is employed as an intermediate, aiding in the creation of agrochemicals that are essential for crop protection and enhancement of agricultural productivity.

Upstream product

• 380883-30-7 1-(cyanomethyl)cyclohexa-2,5-diene-1-carboxylic acid 
• 4630-82-4 methyl cyclohexylcarboxylate 
• 956122-75-1 1-cyanomethyl-cyclohexanecarboxylic acid methyl ester 

Downstream Products

• 176-66-9 2-azaspiro[4.5]decane 

Relevant articles and documents

Simple Synthesis of γ-Spirolactams by Birch Reduction of Benzoic Acids

A convenient synthesis of γ-spirolactams in only two steps was developed. Birch reduction of benzoic acids and immediate alkylation with chloroacetonitrile afforded cyclohexadienes in high yields. The products could be isolated by crystallization on a large scale in analytically pure form. Subsequent hydrogenation with platinum(IV) oxide as the catalyst reduced the nitrile functionality and the double bonds in the same step with excellent stereoselectivity. The relative configurations were determined unequivocally by X-ray analyses. Direct cyclization of the intermediary formed amino acids afforded the desired γ-spirolactams in excellent overall yields. The procedure is characterized by few steps, cheap reagents, and can be performed on a large scale, interesting for industrial processes.

HIGHLY ACTIVE CSF1R INHIBITOR COMPOUND

ABSTRACT The present invention relates to a CSF1R inhibitor, and in particular to a highly active CSF1R inhibitor compound having the structure of formula (I). Said compound of the present invention has high inhibitory activity on CSF1R.

INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1

The present invention discloses novel compounds of Formula (I): having 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11β-HSD type 1 activity.