176-66-9

Basic information

• Product Name: 2-AZASPIRO[4,5]DECANE
• Synonyms: 2-AZASPIRO[4,5]DECANE;2-Azaspiro[4.5]decane heMioxlate;3-azaspiro[4.5]decane
• CAS NO: 176-66-9
• Molecular Formula: C₉H₁₇N
• Molecular Weight: 139.24
• Mol File: 176-66-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 205.7°C at 760 mmHg
• Flash Point: 72.7°C
• Appearance: /
• Density: 0.94g/cm³
• Vapor Pressure: 0.247mmHg at 25°C
• Refractive Index: 1.496
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-AZASPIRO[4,5]DECANE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AZASPIRO[4,5]DECANE(176-66-9)
• EPA Substance Registry System: 2-AZASPIRO[4,5]DECANE(176-66-9)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 176-66-9(Hazardous Substances Data)

Usage

General Description

2-Azaspiro[4,5]decane is a chemical compound with the molecular formula C9H17N. It belongs to the class of organic compounds known as spiro compounds, which are characterized by a bicyclic structure in which two rings share a single carbon atom. 2-Azaspiro[4,5]decane is used as a building block in organic synthesis and pharmaceutical research, where it can be found in the development of potential drug candidates. Its unique structural features make it a valuable starting material for the synthesis of various biologically active compounds. Additionally, 2-Azaspiro[4,5]decane has been studied for its potential pharmacological properties, including its ability to modulate certain neurotransmitter receptors in the central nervous system.

InChI:InChI=1/C9H17N/c1-2-4-9(5-3-1)6-7-10-8-9/h10H,1-8H2

Upstream product

• 64744-50-9 gabapentin-lactam 
• 1005-85-2 2-azaspiro[4.5]decan-1-one 

Downstream Products

• 36392-74-2 2-azoniaspiro[4.5]decane hydrochloride 
• 137795-81-4 (R)-5-(2-Aza-spiro[4.5]dec-2-yl)-4-benzyloxycarbonylamino-5-oxo-pentanoic acid benzyl ester 
• 137795-53-0 (R)-5-(2-Aza-spiro[4.5]dec-2-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoic acid 
• 137795-52-9 (R)-5-(2-Aza-spiro[4.5]dec-2-yl)-4-(3-chloro-benzoylamino)-5-oxo-pentanoic acid 

Relevant articles and documents

Systematic Investigation of the Scope of Transannular C-H Heteroarylation of Cyclic Secondary Amines for Synthetic Application in Medicinal Chemistry

Transannular C-H heteroarylation of amines provides rapid access to complex scaffolds that are otherwise difficult to synthesize. Wide adaptation of this emerging reaction for medicinal chemistry requires a broad understanding of substrate scope and more robust experimental conditions. In this article, we report a new ligand to promote the transannular reaction of a range of fused- and bridged-bicyclic secondary amines with a broad set of heteroarenes. The method was also successfully applied to the arylation of one spiro-bicyclic amine, a class of substrates that has not been studied in the context of transannular C-H activation reactions. The broad application of this transannular C-H heteroarylation methodology is currently hampered by the difficulty of removing the directing group. The development of a new directing group that is easier to remove will expand the utility of this reaction.

PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS

Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, X, and n are as defined for Formula (I) in the description, processes for the preparation of the compounds and new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and the use of the compounds in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction.