1005324-46-8

Basic information

• Product Name: DNV-II iMpurity 1
• Synonyms: DNV-II iMpurity 1;Darunavir Impurity 8;N-[(1R,2S)-2-Hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]carbamic acid 1,1-dimethylethyl ester;Carbamic acid, N-[(1R,2S)-2-hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]-, 1,1-dimethylethyl ester;N-[(1R,2S)-2-Hydroxy-3-[(2-Methylpropyl)[(4-nitrophenyl)sulfonyl]aMino]-1-(phenylMethyl)propyl]carbaMic Acid 1,1-DiMethylethyl Ester (Darunavir IMpurity)
• CAS NO: 1005324-46-8
• Molecular Formula: C₂₅H₃₅N₃O₇S
• Molecular Weight: 521.63
• Mol File: 1005324-46-8.mol

Chemical Properties

• Appearance: /
• Density: 1.241±0.06 g/cm3(Predicted)
• PKA: 11.94±0.46(Predicted)
• CAS DataBase Reference: DNV-II iMpurity 1(CAS DataBase Reference)
• NIST Chemistry Reference: DNV-II iMpurity 1(1005324-46-8)
• EPA Substance Registry System: DNV-II iMpurity 1(1005324-46-8)

Safety Data

• Hazardous Substances Data: 1005324-46-8(Hazardous Substances Data)

Upstream product

• 19901-50-9 methyl (2R)-2-(t-butoxycarbonylamino)-3-phenylpropionate 
• 21685-51-8 D-phenylalanine methyl ester 
• 673-06-3 D-(R)-phenylalanine 
• 1005324-40-2 C₁₉H₃₂N₂O₃ 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 

Downstream Products

• 1402142-62-4 4-amino-N-((2S,3R)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide 
• 1402142-63-5 (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl (2R,3S)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl carbamate 

Relevant articles and documents

First stereoselective total synthesis of (3R, 3aS, 6aR)-hexahydrofuro[2,3- b]furan-3-yl (2R,3S)-4-(4-amino-N-isobutyl phenylsulfonamido)-3-hydroxy-1- phenylbutan-2-yl-carbamate (diastereomer of Darunavir)

The stereoselective novel synthesis of (3R,3aS,6aR)-hexahydrofuro [2,3-b]furan-3-yl (2R,3S)-4-(4-amino-N-isobutyl phenyl sulfonamido)-3-hydroxy-1- phenylbutan-2-yl-carbamate, has been accomplished in situ from the intermediate 4- amino-N-((2S,3R)-3-amino-