tert-butyl (2R, 3S)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl (2R, 3S)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-ylcarbamate
CAS No.:1005324-46-8
Molecular Formula:C₂₅H₃₅N₃O₇S
Molecular Weight:521.635
Hs Code.:
Mol file:1005324-46-8.mol

Synonyms:tert-butyl (2R, 3S)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-ylcarbamate

Suppliers and Price of tert-butyl (2R, 3S)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-ylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-[(1R,2S)-2-Hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]carbamicAcid1,1-DimethylethylEster(DarunavirImpurity)
10mg
$ 160.00

Medical Isotopes, Inc.
N-[(1R,2S)-2-Hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]carbamicAcid1,1-DimethylethylEster(DarunavirImpurity)
100 mg
$ 2200.00

Total 4 raw suppliers

Chemical Property of tert-butyl (2R, 3S)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-ylcarbamate

Chemical Property:

PKA:11.94±0.46(Predicted)
Density:1.241±0.06 g/cm3(Predicted)

Purity/Quality:

> 95% ^*data from raw suppliers

N-[(1R,2S)-2-Hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]carbamicAcid1,1-DimethylethylEster(DarunavirImpurity) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (2R, 3S)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-ylcarbamate

There total 4 articles about tert-butyl (2R, 3S)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1005324-40-2
C₁₉H₃₂N₂O₃

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 1005324-46-8
tert-butyl (2R, 3S)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-ylcarbamate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 673-06-3,25191-15-5,658-69-5,67675-33-6
D-(R)-phenylalanine

: 1005324-46-8
tert-butyl (2R, 3S)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / 5 h / Reflux

2.1: sodium hydrogencarbonate / 16 h / 20 °C

3.1: methylmagnesium chloride / tetrahydrofuran / 0.5 h / 10 °C / Inert atmosphere

3.2: 2.75 h / 10 °C / Reflux

4.1: aluminum isopropoxide; isopropyl alcohol / 3 h / Reflux

5.1: sodium hydroxide / acetone / 1.5 h / 20 °C

6.1: 3 h / Reflux

7.1: triethylamine / dichloromethane / 2 h / 20 °C

With thionyl chloride; methylmagnesium chloride; aluminum isopropoxide; sodium hydrogencarbonate; triethylamine; isopropyl alcohol; sodium hydroxide; In tetrahydrofuran; dichloromethane; acetone;

Reference yield:

: 19901-50-9,51987-73-6,77119-84-7
methyl (2R)-2-(t-butoxycarbonylamino)-3-phenylpropionate

: 1005324-46-8
tert-butyl (2R, 3S)-3-hydroxy-4-(N-isobutyl-4-nitrophenylsulfonamido)-1-phenylbutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: methylmagnesium chloride / tetrahydrofuran / 0.5 h / 10 °C / Inert atmosphere

1.2: 2.75 h / 10 °C / Reflux

2.1: aluminum isopropoxide; isopropyl alcohol / 3 h / Reflux

3.1: sodium hydroxide / acetone / 1.5 h / 20 °C

4.1: 3 h / Reflux

5.1: triethylamine / dichloromethane / 2 h / 20 °C

With methylmagnesium chloride; aluminum isopropoxide; triethylamine; isopropyl alcohol; sodium hydroxide; In tetrahydrofuran; dichloromethane; acetone;