10101-30-1

Basic information

• Product Name: N-Acetyl-DL-histidine, Hydrate
• Synonyms: Acetylhistidinehydrate;NALPHA-Acetyl-DL-histidine;DL-Histidine, N-acetyl-
• CAS NO: 10101-30-1
• Molecular Formula: C₈H₁₁N₃O₃
• Molecular Weight: 215.20652
• Mol File: 10101-30-1.mol

Chemical Properties

• Melting Point: 144-145 °C
• Boiling Point: 620.2±50.0 °C(Predicted)
• Appearance: /
• Density: 1.366±0.06 g/cm3(Predicted)
• PKA: 3.16±0.10(Predicted)
• CAS DataBase Reference: N-Acetyl-DL-histidine, Hydrate(CAS DataBase Reference)
• NIST Chemistry Reference: N-Acetyl-DL-histidine, Hydrate(10101-30-1)
• EPA Substance Registry System: N-Acetyl-DL-histidine, Hydrate(10101-30-1)

Safety Data

• Hazardous Substances Data: 10101-30-1(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 71-00-1 L-histidine 
• 75-36-5 acetyl chloride 
• 71-00-1 D,L-histidine 
• 71-00-1 L-Histidine 

Downstream Products

• 4998-57-6 His 
• 71-00-1 L-histidine 
• 75983-68-5 N^α-acetyl-D-histidine 
• 107089-37-2 N₃-Methyl-N^α-acetyl-4-nitrohistidine methyl ester 
• 351-50-8 D-histidin 

Relevant articles and documents

Regioselective synthesis of tetrasubstituted pyrroles by 1,3-dipolar cycloaddition and spontaneous decarboxylation

We developed a novel regioselective synthesis of tetrasubstituted pyrroles via the classic 1,3-dipolar cycloaddition of α,β-unsaturated benzofuran-3(2H)-one and azlactones (1) followed by spontaneous decarboxylation. The complete regiochemical control of tetrasubstituted pyrroles was confirmed by the orthogonal synthesis of complementary regioisomers (7a and 7b) simply by using different azlactones (1a and 1b, respectively).

Composition containing a penem or carbapenem antibiotic and the use of the same

Administration of an N-acylated amino acid in association with a penem or carbapenem antibiotic relieves or eliminates the renal problems associated with administration of the antibiotic alone. The amino acid derivative and antibiotic may be formulated together as a composition or administered separately, either simultaneously or sequentially.

Composition containing a penem or carbapenem antibiotic

Administration of an N-acylated amino acid in association with a penem or carbapenem antibiotic relieves or eliminates the renal problems associated with administration of the antibiotic alone. The amino acid derivative and antibiotic may be formulated together as a composition or administered separately, either simultaneously or sequentially. The composition may be prepared by simple mixing.