101117-67-3

Basic information

• Product Name: N'-[1-(1-benzofuran-2-yl)ethylidene]isonicotinohydrazide
• Synonyms: N'-[1-(1-benzofuran-2-yl)ethylidene]isonicotinohydrazide
• CAS NO: 101117-67-3
• Molecular Formula: C16H13N3O2
• Molecular Weight: 279.29332
• Mol File: 101117-67-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N'-[1-(1-benzofuran-2-yl)ethylidene]isonicotinohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: N'-[1-(1-benzofuran-2-yl)ethylidene]isonicotinohydrazide(101117-67-3)
• EPA Substance Registry System: N'-[1-(1-benzofuran-2-yl)ethylidene]isonicotinohydrazide(101117-67-3)

Safety Data

• Hazardous Substances Data: 101117-67-3(Hazardous Substances Data)

Upstream product

• 1646-26-0 1-(benzo[b]furan-2-yl)ethanone 
• 54-85-3 isoniazid 

Relevant articles and documents

Probing 2-acetylbenzofuran hydrazones and their metal complexes as α-glucosidase inhibitors

Inhibition of α-glucosidase is one of the important approaches in designing antidiabetic drugs for its role in decrease of the carbohydrates digestion to avoid post-prandial increase in blood sugar levels in diabetic patients. In the present study we designed a novel series of 2-acetylbenzofuran hydrazones (L1-L7) and their metal (II) complexes Cu (II), Co (II), Zn (II) and Mn (II) (8–29) and screened for inhibitory activity against the yeast α-glucosidase. The synthesis of hydrazones incorporated the use of I2 as a catalyst which resulted in excellent yield of 94percent. The ligand L3, showed good activity (IC50 = 47.51 ± 0.86 μM) while its metal complex (10) showed potent activity (IC50 = 1.15 ± 0.001 μM) compared to reference acarbose IC50 = 378.25 ± 0.12 μM. Similarly, the Cu (II) complexes with ligands L5 and L6 showed excellent α-glucosidase inhibition (IC50 = 0.15 ± 0.003 12 and 0.21 ± 0.002 μM for 13, respectively) whereas, the metal complexes of Co (II), Mn (II), and Zn (II) showed moderate to poor inhibitory activities against α-glucosidase. The The findings are supported by the ligands and enzyme interactions through molecular docking studies. In conclusion, it is indicated that metal complexes of 2-acetylbenzofuran hydrazones have good potential for research leading to antidiabetic therapies.