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CAS

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101140-06-1

Amentoflavone, a biflavonoid compound, is naturally found in various plants such as Ginkgo biloba and certain moss species. It exhibits a wide range of pharmacological properties, including anti-inflammatory, anti-viral, anti-cancer, anti-diabetic, antioxidant, and neuroprotective effects. Amentoflavone interacts with multiple enzymes and biological systems, such as inhibiting the enzyme PDE4 and binding to GABA receptors. However, its low water solubility and bioavailability necessitate further research to develop efficient drug delivery systems.

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  • 101140-06-1 Structure

  • Basic information

    1. Product Name: AMENTOFLAVONE
    2. Synonyms: 8,3''-Biapigenin;Biapigenin;5,5',7,7'-Tetrahydroxy-2,2'-bis(4-hydroxyphenyl)-4H,4'H-[3,8'-bichroMene]-4,4'-dione;5,5′,7,7′-Tetrahydroxy-2,2′-bis(4-hydroxyphenyl)-[3,8′-bi-4H-1-benzopyran]-4,4′-dione
    3. CAS NO:101140-06-1
    4. Molecular Formula: C30H18O10
    5. Molecular Weight: 538.462
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 101140-06-1.mol

  • Chemical Properties

    1. Melting Point: 258-260 °C
    2. Boiling Point: 910.5°Cat760mmHg
    3. Flash Point: 308.4°C
    4. Appearance: /
    5. Density: 1.656g/cm3
    6. Vapor Pressure: 2.79E-35mmHg at 25°C
    7. Refractive Index: 1.793
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. PKA: 5.57±0.40(Predicted)
    11. BRN: 1415589
    12. CAS DataBase Reference: AMENTOFLAVONE(CAS DataBase Reference)
    13. NIST Chemistry Reference: AMENTOFLAVONE(101140-06-1)
    14. EPA Substance Registry System: AMENTOFLAVONE(101140-06-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: S22:; S24/25:;
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 101140-06-1(Hazardous Substances Data)

101140-06-1 Usage

Uses

Used in Pharmaceutical Industry:
Amentoflavone is used as a therapeutic agent for its diverse pharmacological properties, including anti-inflammatory, anti-viral, anti-cancer, anti-diabetic, antioxidant, and neuroprotective effects. Its interaction with enzymes and biological systems, such as PDE4 inhibition and GABA receptor binding, makes it a promising candidate for the development of new drugs.
Used in Drug Delivery Systems:
To overcome the limitations of amentoflavone's low water solubility and bioavailability, novel drug delivery systems are being researched and developed. These systems aim to enhance the delivery, bioavailability, and therapeutic outcomes of amentoflavone, improving its efficacy in various applications. Various organic and metallic nanoparticles are being explored as carriers for amentoflavone delivery, potentially enhancing its pharmaceutical applications.

Check Digit Verification of cas no

The CAS Registry Mumber 101140-06-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,1,4 and 0 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 101140-06:
(8*1)+(7*0)+(6*1)+(5*1)+(4*4)+(3*0)+(2*0)+(1*6)=41
41 % 10 = 1
So 101140-06-1 is a valid CAS Registry Number.
InChI:InChI=1/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-36H

101140-06-1 Well-known Company Product Price

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  • Sigma-Aldrich

  • (73962)  I3,II8-Biapigenin  analytical standard

  • 101140-06-1

  • 73962-10MG

  • 10,062.00CNY

  • Detail

101140-06-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name I3,II8-Biapigenin

1.2 Other means of identification

Product number -
Other names 8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:101140-06-1 SDS

101140-06-1Downstream Products

101140-06-1Relevant articles and documents

Preparation method of natural biflavones such as I3,II8-Biapgienin and Ridiculuflavone A

-

, (2017/08/28)

The present invention belongs to the field of new compound preparation methods and medicine research, and particularly relates to a preparation method of natural biflavones such as I3,II8-Biapgienin and Ridiculuflavone A. According to the present invention, the two compounds such as I3,II8-Biapgienin and Ridiculuflavone A are firstly synthesized, wherein I3,II8-Biapgienin has good anti-depression activity, good anti-tumor activity, good anti-oxidation activity, good anti-inflammatory activity and good anti-liver injury activity, further has inhibition activity on estrogen receptors, benzodiazepine receptors and CYP, and has broad prospects in the fields of drug development and application.

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