18962-05-5

Usage

Chemical Properties

clear colorless to yellow liquid

InChI:InChI=1/C10H12O2/c1-8(2)12-10-5-3-9(7-11)4-6-10/h3-8H,1-2H3

Upstream product

• 75-30-9 2-iodo-propane 
• 123-08-0 4-hydroxy-benzaldehyde 
• 459-57-4 4-fluorobenzaldehyde 
• 67-63-0 isopropyl alcohol 
• 683-60-3 sodium isopropylate 
• 104-88-1 4-chlorobenzaldehyde 
• 15164-44-0 p-(iodophenyl)carboxaldehyde 
• 82657-71-4 (4-isopropoxyphenyl)methanol 
• 75-26-3 isopropyl bromide 

Downstream Products

• 93005-74-4 3-((Ξ)-4-isopropoxy-benzylidene)-dihydro-furan-2-one 
• 117986-77-3 4-isopropoxy-benzaldehyde-selenosemicarbazone 
• 90740-83-3 (4-Isopropoxy-phenyl)-(3-methyl-isothiazol-5-yl)-methanol 
• 20718-93-8 4-isopropoxy-benzaldehyde-thiosemicarbazone 
• 88795-80-6 ethyl ester of the 2-propyl-3-(p-isopropoxyphenyl)-2,3-epoxypropionic acid 
• 127034-08-6 (E)-3-(4-Isopropoxy-phenyl)-1-(3,4,5-trimethoxy-phenyl)-propenone 
• 88795-79-3 ethyl ester of the 2-ethyl-3-(p-isopropoxyphenyl)-2,3-epoxypropionic acid 
• 88795-81-7 ethyl ester of the 2-butyl-3-(p-isopropoxyphenyl)-2,3-epoxypropionic acid 
• 104937-45-3 3-{2-Hydroxy-4,6-diisopropoxy-3-[(E)-3-(4-isopropoxy-phenyl)-acryloyl]-phenyl}-3-phenyl-propionic acid 
• 88795-78-2 ethyl ester of the 2-methyl-3-(p-isopropoxyphenyl)-2,3-epoxypropionic acid 
• 587870-64-2 α-phenyl-p-isopropoxycinnamic acid 
• 587870-65-3 α-(p-isopropoxyphenyl)-p-isopropoxycinnamic acid 
• 587870-66-4 α-(m-isopropoxyphenyl)-p-isopropoxycinnamic acid 
• 7495-77-4 4-isopropoxyphenol 

Relevant academic research and scientific papers

NOVEL COMPOUNDS FOR SKIN LIGHTENING

Novel compounds are disclosed. Skin lightening composition comprising said compounds and method of skin lightening is disclosed too. In addition, method of synthesizing said novel compounds are disclosed.

NOVEL COMPOUNDS FOR SKIN LIGHTENING

A novel compound is disclosed. Skin lightening composition comprising said compound and method of skin lightening is disclosed too. In addition, method of synthesizing said novel compound is disclosed.

Soluble/MOF-Supported Palladium Single Atoms Catalyze the Ligand-, Additive-, and Solvent-Free Aerobic Oxidation of Benzyl Alcohols to Benzoic Acids

Metal single-atom catalysts (SACs) promise great rewards in terms of metal atom efficiency. However, the requirement of particular conditions and supports for their synthesis, together with the need of solvents and additives for catalytic implementation, often precludes their use under industrially viable conditions. Here, we show that palladium single atoms are spontaneously formed after dissolving tiny amounts of palladium salts in neat benzyl alcohols, to catalyze their direct aerobic oxidation to benzoic acids without ligands, additives, or solvents. With this result in hand, the gram-scale preparation and stabilization of Pd SACs within the functional channels of a novel methyl-cysteine-based metal-organic framework (MOF) was accomplished, to give a robust and crystalline solid catalyst fully characterized with the help of single-crystal X-ray diffraction (SCXRD). These results illustrate the advantages of metal speciation in ligand-free homogeneous organic reactions and the translation into solid catalysts for potential industrial implementation.

Fluorine-Directed Glycosylation Enables the Stereocontrolled Synthesis of Selective SGLT2 Inhibitors for Type II Diabetes

Inhibition of the sodium-glucose co-transporters (SGLT1 and SGLT2) is a validated strategy to address the increasing prevalence of type II diabetes mellitus. However, achieving selective inhibition of human SGLT1 or SGLT2 remains challenging. Orally available small molecule drugs based on the d-glucose core of the natural product Gliflozin have proven to be clinically effective in this regard, effectively impeding glucose reabsorption. Herein, we disclose the influence of molecular editing with fluorine at the C2 position of the pyranose ring of Phlorizin analogues Remogliflozin Etabonate and Dapagliflozin (Farxiga) to concurrently direct β-selective glycosylation, as is required for biological efficacy, and enhance aspects of the physicochemical profile. Given the abundance of glycosylated pharmaceuticals in diabetes therapy that contain a β-configured d-glucose nucleus, it is envisaged that this strategy may prove to be expansive.

Syntheses and characterization of aryl-substituted pyrogallol[4]arenes and resorcin[4]arenes

Seven aryl-substituted pyrogallol[4]arenes and six aryl-substituted resorcin[4]arenes were synthesized through the acid catalyzed reaction of either pyrogallol or resorcinol with a specific alkoxybenzaldehyde. Single crystal X-ray data was obtained for all thirteen compounds. In order to determine the effect of the different pendent -R groups, four properties were investigated: π-π distance, inward tilt, twist angle, and the angle between the planes containing the pendent -R groups. Positioning of the -R groups, the carbon atom chain length of the -R groups, the number of upper-rim hydroxyl groups (resorcin[4]arene vs. pyrogallol[4]arene), and the number of substituted phenyl groups all influenced these four properties. The trends that develop are investigated and discussed.

Intermolecular C–O Coupling Using Hemicucurbituril Supported Ionic Liquid Phase Catalyst

Abstract: Hemicucurbituril supported ionic liquid phase catalyst (HmCucSILP) has been synthesized by anchoring multilayer of ionic liquid ([Bmim]Cl) containing Pd(OAc)2 and X-phos on the surface of hemicucurbit[6]uril. The HmCucSILP was effectively employed in intermolecular C–O coupling of aryl halides with sodium alkoxides for the synthesis of alkyl aryl ethers. Graphical Abstract: [Figure not available: see fulltext.]

Pro-angiogenic effects of chalcone derivatives in zebrafish embryos in vivo

The aim of this study was to investigate novel chalcones with potent angiogenic activities in vivo. Chalcone-based derivatives were evaluated using a transgenic zebrafish line with fluorescent vessels to real-time monitor the effect on angiogenesis. Results showed that the chalcone analogues did not possess anti-angiogenic effect on zebrafish vasculatures; instead, some of them displayed potent pro-angiogenic effects on the formation of the sub-intestinal vein. Similar pro-angiogenic effects can also be seen on wild type zebrafish embryos. Moreover, the expression of vegfa, the major regulator for angiogenesis, was also upregulated in their treatment. Taken together, we have synthesized and identified a series of novel chalcone-based derivatives as potent in vivo pro-angiogenic compounds. These novel compounds hold potential for therapeutic angiogenesis.

ANTIBACTERIAL AGENTS: ARYL MYXOPYRONIN DERIVATIVES

The invention provides compounds of formula la, lb and Ic: [Formula Ia, Ib, and Ic] and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.

Reactivity assessment of chalcones by a kinetic thiol assay

The electrophilic nature of chalcones (1,3-diphenylprop-2-en-1-ones) and many other α,β-unsaturated carbonyl compounds is crucial for their biological activity, which is often based on thiol-mediated regulation processes. To better predict their biological activity a simple screening assay for the assessment of the second-order rate constants (k2) in thia-Michael additions was developed. Hence, a clear structure-activity relationship of 16 differentially decorated hydroxy-alkoxychalcones upon addition of cysteamine could be established. Moreover, amongst other naturally occurring α,β-unsaturated carbonyl compounds k2 values for curcumin and cinnamaldehyde were gained while cinnamic acids or esters gave no or very slow reactions.

Facile synthesis of diarylmethanes via quinone methides

A novel acid-mediated generation of quinone methides followed by nucleophilic addition of electronrich aromatic compounds to furnish diarylmethanes has been developed. A wide range of electronrich aromatic compounds including some heterocycles can be employed for this reaction to provide the corresponding diarylmethanes in good yields and regioselectivities.