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101828-21-1

N-Methyl-N-(naphthalen-1-ylmethyl)-1-(4-tert-butylphenyl)methanamine, also known as Butenafine, is a synthetic benzylamine antifungal agent structurally and pharmacologically related to terbinafine. It functions as an inhibitor of squalene epoxidase, an enzyme crucial for the synthesis of sterols in fungal cell membranes. This inhibition leads to a decrease in ergosterol and an increase in squalene, causing alterations in cell membrane permeability and ultimately resulting in cell death.

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  • 101828-21-1 Structure

  • Basic information

    1. Product Name: N-Methyl-N-(naphthalen-1-ylmethyl)-1-(4-tert-butylphenyl)methanamine
    2. Synonyms: BUTENAFINE;n-methyl-n-(naphthalen-1-ylmethyl)-1-(4-tert-butylphenyl)methanamine;n-(p-tert-butylbenzyl)-n-methyl-1-naphthalenemethylamine;N-methyl-N-(4-methylbenzyl)-N-(1-naphthylmethyl)amine;4-tert-Butylbenzylmethyl 1-naphtylmethylamine;N-(4-tert-Butylbenzyl)-N-methyl-1-naphthalenemethanamine;(4-tert-butylbenzyl)-methyl-(1-naphthylmethyl)amine;1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine
    3. CAS NO:101828-21-1
    4. Molecular Formula: C23H27N
    5. Molecular Weight: 317.47
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 101828-21-1.mol

  • Chemical Properties

    1. Melting Point: 200-202 °C
    2. Boiling Point: 426.094 °C at 760 mmHg
    3. Flash Point: 187.687 °C
    4. Appearance: /
    5. Density: 1.032 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 7.87±0.50(Predicted)
    10. CAS DataBase Reference: N-Methyl-N-(naphthalen-1-ylmethyl)-1-(4-tert-butylphenyl)methanamine(CAS DataBase Reference)
    11. NIST Chemistry Reference: N-Methyl-N-(naphthalen-1-ylmethyl)-1-(4-tert-butylphenyl)methanamine(101828-21-1)
    12. EPA Substance Registry System: N-Methyl-N-(naphthalen-1-ylmethyl)-1-(4-tert-butylphenyl)methanamine(101828-21-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 101828-21-1(Hazardous Substances Data)

101828-21-1 Usage

Uses

Used in Dermatology:
N-Methyl-N-(naphthalen-1-ylmethyl)-1-(4-tert-butylphenyl)methanamine is used as an antifungal agent for the treatment of dermatological fungal infections. Its application is particularly effective against dermatophytes, yeast, and Sporothrix due to its ability to inhibit squalene epoxidase, disrupting the fungal cell membrane and causing cell death.
Used in Antifungal Medications:
N-Methyl-N-(naphthalen-1-ylmethyl)-1-(4-tert-butylphenyl)methanamine is used as the active ingredient in antifungal medications, such as Lotrimin (Schering) and Mentax (Mylan Bertek), for treating various skin infections caused by fungi. Its effectiveness in inhibiting squalene epoxidase makes it a valuable component in these medications, providing relief and treatment for patients suffering from fungal infections.

Check Digit Verification of cas no

The CAS Registry Mumber 101828-21-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,8,2 and 8 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 101828-21:
(8*1)+(7*0)+(6*1)+(5*8)+(4*2)+(3*8)+(2*2)+(1*1)=91
91 % 10 = 1
So 101828-21-1 is a valid CAS Registry Number.
InChI:InChI=1/C23H27N/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20/h5-15H,16-17H2,1-4H3

101828-21-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name butenafine

1.2 Other means of identification

Product number -
Other names Butenafine HCL

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:101828-21-1 SDS

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