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CAS

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103-12-8

p-[(2,4-diaminophenyl)azo]benzenesulphonamide, also known as Prontosil, is a diphenyldiazene compound with two amino substituents at the 2and 4-positions and an aminosulphonyl substituent at the 4'-position. It is recognized as the first antibacterial drug, introduced in 1935, and belongs to the class of sulfonamide antibiotics.

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  • 103-12-8 Structure

  • Basic information

    1. Product Name: Sulfamidochrysoidine
    2. Synonyms: p-[(2,4-diaminophenyl)azo]benzenesulphonamide;sulfamidochrysoidine;Parazol;Prontosil flavum;Prontosil rubrum;Pronzin rubrum;Relbazon;Rubiazol I
    3. CAS NO:103-12-8
    4. Molecular Formula: C12H13N5O2S
    5. Molecular Weight: 291.32892
    6. EINECS: 203-081-2
    7. Product Categories: N/A
    8. Mol File: 103-12-8.mol

  • Chemical Properties

    1. Melting Point: 249.5°C
    2. Boiling Point: 601.2°Cat760mmHg
    3. Flash Point: 317.4°C
    4. Appearance: /
    5. Density: 1.4999 (rough estimate)
    6. Vapor Pressure: 2.06E-14mmHg at 25°C
    7. Refractive Index: 1.5630 (estimate)
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: 9.73±0.10(Predicted)
    11. CAS DataBase Reference: Sulfamidochrysoidine(CAS DataBase Reference)
    12. NIST Chemistry Reference: Sulfamidochrysoidine(103-12-8)
    13. EPA Substance Registry System: Sulfamidochrysoidine(103-12-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 103-12-8(Hazardous Substances Data)

103-12-8 Usage

Uses

Used in Pharmaceutical Industry:
p-[(2,4-diaminophenyl)azo]benzenesulphonamide is used as an antibacterial agent for its ability to inhibit bacterial growth and treat infections caused by susceptible bacteria. Its historical significance as the first sulfonamide antibiotic has paved the way for the development of a wide range of antibiotics that have revolutionized the treatment of bacterial infections.
Used in Research and Development:
In addition to its clinical applications, p-[(2,4-diaminophenyl)azo]benzenesulphonamide is also used as a research tool in the development of new antibiotics and the study of bacterial resistance mechanisms. Its unique chemical structure and properties make it a valuable compound for understanding the interactions between antibiotics and bacterial cells, which can contribute to the design of more effective and targeted treatments.

Uses

Used in Textile Industry:
p-[(2,4-diaminophenyl)azo]benzenesulphonamide is used as a dye in the textile industry for imparting a bright red-orange color to fabrics. Its unique color characteristics and affinity for certain types of fibers make it a preferred choice for specific applications in textile manufacturing.

Check Digit Verification of cas no

The CAS Registry Mumber 103-12-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 3 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 103-12:
(5*1)+(4*0)+(3*3)+(2*1)+(1*2)=18
18 % 10 = 8
So 103-12-8 is a valid CAS Registry Number.
InChI:InChI=1/C12H13N5O2S/c13-8-1-6-12(11(14)7-8)17-16-9-2-4-10(5-3-9)20(15,18)19/h1-7H,13-14H2,(H2,15,18,19)/b17-16+

103-12-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name prontosil

1.2 Other means of identification

Product number -
Other names 4-(2,4-diamino-phenylazo)-benzenesulfonic acid amide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:103-12-8 SDS

103-12-8Downstream Products

103-12-8Relevant articles and documents

Synthesis of a novel class of chromophoric cross-linkers

Haghbeen, Kamahldin,Legge, Raymond L.

, p. 957 - 965 (2016)

Considering the special place of aromatic diazo compounds in photo-responsive materials and growing demand for materials with interesting optical properties, a new class of chromophoric cross-linkers was synthesized by acrylation of diazo derivatives of m-diaminobenzene. The cross-linkers are soluble in a wide variety of organic solvents as well as in mixtures of water and water miscible solvents. The chromophores of the cross-linkers are stable in protic and some certain aprotic solvents and remain stable after cross-linking. The chemical structure of this class allows one to have a cross-linker with tuned chemical reactivity and solubility with post-linking applicability. The cross-linkers are obtained from reactions with simple chemistry in high yields and are able to participate in radical and ionic polymerization as well as in nucleophilic addition reactions. Successful participation of these substances in acrylamide polymerization and sol-gel preparation is demonstrated.

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