108-45-2

Basic information

• Product Name: m-Phenylenediamine
• Synonyms: benzene-1,3-diamine;C.I. 76025;C.I. Developer 11;c.i.76025;c.i.developer11;ci76025;cideveloper11;Developer 11
• CAS NO: 108-45-2
• Molecular Formula: C₆H₈N₂
• Molecular Weight: 108.14
• EINECS: 203-584-7
• Product Categories: VARIOUSAMINE;Intermediates of Dyes and Pigments;1,3-Benzenediamine;Organics;Amines;Fluorenes, etc. (reagent for high-performance polymer research);Functional Materials;Reagent for High-Performance Polymer Research;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Polyamines;Indazoles;Fine Chemicals
• Mol File: 108-45-2.mol
• Article Data: 337

Chemical Properties

• Melting Point: 64-66 °C(lit.)
• Boiling Point: 282-284 °C(lit.)
• Flash Point: >230 °F
• Appearance: Yellow to light tan or brown gray/pellets
• Density: 1,139 g/cm3
• Vapor Density: 3.7 (vs air)
• Vapor Pressure: 0.62 mm Hg ( 100 °C)
• Refractive Index: 1.6339
• Storage Temp.: Store below +30°C.
• Solubility: 350g/l
• PKA: 5.11, 2.50(at 20℃)
• Water Solubility: 350 g/L (25 ºC)
• Sensitive: Air Sensitive
• Merck: 14,7283
• BRN: 471357
• CAS DataBase Reference: m-Phenylenediamine(CAS DataBase Reference)
• NIST Chemistry Reference: m-Phenylenediamine(108-45-2)
• EPA Substance Registry System: m-Phenylenediamine(108-45-2)

Safety Data

• Hazard Codes: T,N
• Statements: 23/24/25-36-43-50/53-68-40
• Safety Statements: 28-36/37-45-60-61-28A
• RIDADR: UN 1673 6.1/PG 3
• WGK Germany: 2
• RTECS: SS7700000
• F: 8-10-23
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 108-45-2(Hazardous Substances Data)

Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 108-45-2 differently. You can refer to the following data:
1. Grey crystal granule
2. m-Phenylenediamine is a colorless to white crystalline substance that turns red upon exposure to air

Uses

Different sources of media describe the Uses of 108-45-2 differently. You can refer to the following data:
1. 1,3-Phenylenediamine is used in the foaming-type hair dye composition.
2. The appearance of the high purity of the m-phenylenediamine is snow white flake solid used as a synthetic electronic grade polyimide material and epoxy resin curing agent.
3. m-Phenylenediamine is used in the foaming-type hair dye composition. It is used as a synthetic electronic grade polyimide material and epoxy resin curing agent. It is used also block polymers, textile fibers, urethanes, petroleum additives, rubber chemicals, in corrosion inhibitors, in photography, as reagent for gold & bromine.

Synthesis Reference(s)

Journal of the American Chemical Society, 102, p. 6182, 1980 DOI: 10.1021/ja00539a054The Journal of Organic Chemistry, 37, p. 930, 1972 DOI: 10.1021/jo00972a002

General Description

Colorless or white colored needles that turn red or purple in air. Melting point 64-66 C. Density 1.14 g / cm3. Flash point 280 F. May irritate skin and eyes. Toxic by skin absorption, inhalation or ingestion. Used in aramid fiber manufacture, as a polymer additive, dye manufacturing, as a laboratory reagent, and in photography.

Air & Water Reactions

Soluble in water [Merck].

Reactivity Profile

m-Phenylenediamine an aromatic amine, neutralizes acids, acid chlorides, acid anhydrides and chloroformates in exothermic reactions to form salts. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Incompatible with oxidizing agents .

Fire Hazard

m-Phenylenediamine is combustible. Dust may form explosive mixtures in air

Flammability and Explosibility

Nonflammable

Safety Profile

Suspected carcinogen with experimental tumorigenic and teratogenic data. Poison by ingestion, intravenous, subcutaneous, and intraperitoneal routes. Mildly toxic by skin contact. Mutation data reported. Combustible when exposed to heat or flame. A hair dye ingredtent. When heated to decomposition it emits toxic fumes of NOx. See also other phenylenediamine entries and AMINES.

Potential Exposure

Used in making various dyes; as a curing agent for epoxy resin; rubber, textile fibers; urethanes, corrosion inhibitors; adhesives; in photographic and analytical procedures and processes.

Carcinogenicity

"Occupational exposure to m-PDA may occur through inhalation and dermal contact with this compound at workplace where m-PDA is produced or used. The general population may be exposed to m-PDA via dermal contact with consumer products containing this compound."An IARC Working Group concluded, on the basis of lack of human data and inadequate animal data, that m-PDA was not classifiable (Group 3) as to its carcinogenicity to humans.

Metabolic pathway

By the perfused rat liver, 1,3-diaminobenzene (MPD) is metabolized to three identified N-acetylated derivatives N-acetyl-1,3-diaminobenzene, N,N'- diacetyl-1,3-diaminobenzene, and N,N'-diacetyl-2,4- diaminophenol which are identical to the metabolites excreted in rat urine.

Shipping

UN1673 Phenylenediamines (o-, m-, p-), Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Purify the diamine by distillation under a vacuum followed by recrystallisation from EtOH (rhombs) and if necessary redistillation. It should be protected from light; otherwise it darkens rapidly. [Neilson et al. J Chem Soc 371 1962, IR: Katritzky & Jones J Chem Soc 3674, 2058 1959, UV: Forbes & Leckie Can J Chem 36 1371 1958.] The hydrochloride has m 277-278o, and the bis-4-chlorobenzenesulfonyl derivative has m 220-221o from H2O (214-215o, from MeOH/H2O) [Runge & Pfeiffer Chem Ber 90 1737 1957]. The acetate has m 191o. [Beilstein 13 IV 79.]

Incompatibilities

Dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, acid chlorides; acid anhydrides; chloroformates. Heat and light contribute to instability. Keep away from metals.

Waste Disposal

Controlled incineration whereby oxides of nitrogen are removed from the effluent gas by scrubber, catalytic or thermal device.

InChI:InChI=1/C6H8N2/c7-5-2-1-3-6(8)4-5/h1-4H,7-8H2

Synthetic route

meta-dinitrobenzene (99-65-0) → m-phenylenediamine (108-45-2)

Conditions	Yield
With sodium tetrahydroborate In water at 20℃; for 1h;	100%
With hydrogen; sodium fluoride In methanol at 39.84℃; for 2.17h;	100%
With hydrogen In ethanol at 20℃; under 760.051 Torr; for 3h; chemoselective reaction;	100%

3-nitro-aniline (99-09-2) → m-phenylenediamine (108-45-2)

Conditions	Yield
With C37H23Cl2N7Pd2(2+)*2F6P(1-); hydrogen; sodium cyanoborohydride In methanol at 50℃; under 760.051 Torr; for 6h;	100%
With potassium fluoride; polymethylhydrosiloxane; palladium diacetate In tetrahydrofuran; water at 20℃; for 0.5h;	99%
With potassium fluoride; polymethylhydrosiloxane; palladium diacetate In tetrahydrofuran at 20℃; for 0.5h;	99%

1,3-dibromobenzene (108-36-1) → m-phenylenediamine (108-45-2)

Conditions	Yield
With C24H12Cu2F9N4O7; tetrabutylammomium bromide; ammonia; caesium carbonate In water at 110 - 140℃; for 16h;	99%
With {(o-C6H4(NCHC6H4O)2)cobalt(II)}2; ammonia at 150℃; under 1500.15 Torr; for 10h; Autoclave; Inert atmosphere; Large scale;	73%
With ammonia; water; copper(II) sulfate at 175 - 180℃;

1,3-Diiodobenzene (626-00-6) → m-phenylenediamine (108-45-2)

Conditions	Yield
With [Cu2(2,7-bis(pyridin-2-yl)-l,8-naphthyridine)(OH)(CF3COO)3]; tetrabutylammomium bromide; ammonia; caesium carbonate In water at 120℃; for 16h; Sealed tube; chemoselective reaction;	99%
With copper(l) iodide; 1,2,4,5-tetramethylbenzene; ammonia at 20℃; for 15h; Reagent/catalyst;	94%

isophthalamide (1740-57-4) → m-phenylenediamine (108-45-2)

Conditions	Yield
With sodium hypochlorite; water at -5 - 50℃; for 2h; Temperature; Inert atmosphere;	97%
With sodium hypochlorite In water at -5 - 50℃; for 4h; Temperature; Hofmann Rearrangement; Inert atmosphere;	84.2%
With sodium hypochlorite at 45℃; for 6h; Green chemistry;	92 g
With sodium hypochlorite; potassium hydroxide at 0 - 80℃; Hofmann Rearrangement; Inert atmosphere;	7.1 g

H2NC6H3(Cl)NO2 (6283-25-6) → m-phenylenediamine (108-45-2)

Conditions	Yield
With palladium 10% on activated carbon; hydrazine hydrate In methanol at 120℃; for 0.25h; Microwave irradiation;	96%

1-bromo-3-chlorobenzene (108-37-2) → m-phenylenediamine (108-45-2)

Conditions	Yield
With ammonium hydroxide In water at 20℃; for 9h; Green chemistry;	96%

m-aminophenyl azide (14994-81-1) → m-phenylenediamine (108-45-2)

Conditions	Yield
With hydrazinium monoformate; zinc In methanol at 20℃; for 0.15h;	95%

C8H6N2O4(2-)*2K(1+) → m-phenylenediamine (108-45-2)

Conditions	Yield
In water; acetonitrile at 110℃; for 2h;	95%

3-bromoaniline (591-19-5) → m-phenylenediamine (108-45-2)

Conditions	Yield
With copper(I) oxide; ammonium hydroxide In 1-methyl-pyrrolidin-2-one at 80℃; for 24h;	94%
With copper(l) iodide; tetra(n-butyl)ammonium hydroxide; ammonia In water at 80℃; for 48h; Inert atmosphere; Sealed tube; chemoselective reaction;	75%

1,3-diacetylbenzene (6781-42-6) → m-phenylenediamine (108-45-2)

Conditions	Yield
Stage #1: 1,3-diacetylbenzene With hydroxylamine hydrochloride at 80℃; for 3h; Stage #2: With hydrogenchloride In water at 100℃; for 2h; Temperature; Concentration;	92%

3-Iodoaniline (626-01-7) → m-phenylenediamine (108-45-2)

Conditions	Yield
With potassium phosphate; copper(l) iodide; N-((1-oxy-pyridin-2-yl)methyl)oxalamic acid; ammonia In water; dimethyl sulfoxide at 25℃; Schlenk technique; Inert atmosphere; Sealed tube; chemoselective reaction;	91%
Stage #1: 3-Iodoaniline With copper(l) iodide; L-valine; caesium carbonate In dimethyl sulfoxide at 90℃; for 24h; Inert atmosphere; Stage #2: With oxygen In dimethyl sulfoxide at 90℃; for 24h; Stage #3: With hydrogenchloride In dichloromethane; water; dimethyl sulfoxide at 20℃; for 0.333333h; pH=1;	28%

meta-dinitrobenzene (99-65-0) → m-phenylenediamine (108-45-2) + 3-nitro-aniline (99-09-2)

Conditions	Yield
With hydrogen; PdCl2-anthranilic acid catalyst In ethanol at 60℃; under 77572.2 Torr; for 1h;	A 90% B 1%
With hydrogen; trans-Pdpy2Cl2 In ethanol at 30℃; for 6h;	A 90% B 4.5%
With hydrogen In methanesulfonic acid at 150℃; under 22502.3 Torr; for 1h; Autoclave;	A 25% B 75%

3-Aminophenylboronic acid (30418-59-8) → m-phenylenediamine (108-45-2)

Conditions	Yield
With sodium hydroxide; hydroxylamine-O-sulfonic acid In acetonitrile at 20℃; for 16h;	90%
With copper(I) oxide; ammonium hydroxide; air In methanol at 20℃; for 12h;	89%

3-(1-hydroxyethyl)aniline (2454-37-7) → m-phenylenediamine (108-45-2)

Conditions	Yield
With sodium azide; trifluoroacetic acid In hexane at 40℃; for 4h; Sealed tube;	87%
With sodium azide; methanesulfonic acid; trifluoroacetic acid In hexane at 40℃; for 12h;	87%

1,3-Dichlorobenzene (541-73-1) → m-phenylenediamine (108-45-2)

Conditions	Yield
With ammonia; 0.8Ni*0.2Cu*C20H16N2O2 at 160℃; under 1500.15 Torr; for 11h; Reagent/catalyst; Autoclave; Inert atmosphere;	84%
With ammonium hydroxide; potassium phosphate; Cu0.18Bi0.88O0.88I1.06 In ethanol; water at 80℃; for 20h; Inert atmosphere; Green chemistry;	98 %Chromat.

2,6-dinitrotoluene (606-20-2) → 4-methylbenzene-1,3-diamine (95-80-7) + m-phenylenediamine (108-45-2) + diaminoxylene

Conditions	Yield
With carbon monoxide; hydrogen sulfide; iron(III) oxide at 325℃; for 1.05h; Product distribution; Mechanism; var. time;	A 80.2% B 4.5% C n/a

3-nitrophenyl azide (1516-59-2) → m-phenylenediamine (108-45-2)

Conditions	Yield
With hydrogenchloride; indium In tetrahydrofuran at 20℃; for 8h;	76%

3-nitro-aniline (99-09-2) → 3,3'-diaminoazobenzene (21371-44-8, 140661-36-5) + m-phenylenediamine (108-45-2)

Conditions	Yield
With ethylenediamine at 150℃;	A 24% B 75%

2,4-dinitrotoluene (121-14-2) → 4-methylbenzene-1,3-diamine (95-80-7) + 4,6-dimethyl-1,3-benzenediamine (3134-10-9) + m-phenylenediamine (108-45-2)

Conditions	Yield
With carbon monoxide; hydrogen sulfide; iron(III) oxide at 325℃; for 1.73333h; Product distribution; Mechanism; var. time, further catalyst: 5percent Co on γ-Al2O3;	A 61% B 29.6% C 9.3%

3-(prop-1-en-2-yl)aniline (23809-98-5) → m-phenylenediamine (108-45-2)

Conditions	Yield
Stage #1: 3-(prop-1-en-2-yl)aniline With sodium azide; trifluoroacetic acid In hexane; water at 20 - 40℃; for 4h; Stage #2: With sodium hydroxide In water at 0℃; for 0.333333h; Reagent/catalyst;	55%

ammonium hydroxide (1336-21-6) + 3-chloro-aniline (108-42-9) → m-phenylenediamine (108-45-2)

Conditions	Yield
With copper(l) iodide In water at 200℃; for 2h; Autoclave;	54%

aniline (62-53-3) → m-phenylenediamine (108-45-2)

Conditions	Yield
With titanium; sulfuric acid; hydroxylamine Mechanism; other aromatic compounds electrochemical amination, dropping mercury electrode; var. solvents;	0.1%

2,4-dinitrobromobenzene (584-48-5) → m-phenylenediamine (108-45-2)

Conditions	Yield
With hydrogenchloride; tin

1-chloro-3,5-dinitrobenzene (618-86-0) → m-phenylenediamine (108-45-2)

Conditions	Yield
With methanol; sodium hydroxide; nickel Hydrogenation;
With sodium hydroxide; nickel; isopropyl alcohol Hydrogenation;

3.5-diaminobenzoic acid (535-87-5) → m-phenylenediamine (108-45-2)

Conditions	Yield
With barytes bei Destillation;

2,6-dinitrobenzoic acid (603-12-3) → m-phenylenediamine (108-45-2)

Conditions	Yield
With hydrogenchloride; tin

2,4,6-tribromo-1,3-dinitrobenzene (51686-79-4) → m-phenylenediamine (108-45-2)

Conditions	Yield
With hydrogenchloride; tin

2,4,6-tribromo-1,3-dinitrobenzene (51686-79-4) → 2,4,6-tribromo-1,3-phenylenediamine (62477-06-9) + m-phenylenediamine (108-45-2)

Conditions	Yield
With acetic acid; zinc

carbon disulfide (75-15-0) + 2-[2-(vinyloxy)ethoxymethyl]oxirane (16801-19-7) + m-phenylenediamine (108-45-2) → 1,3-di<9-vinyloxy-5-hydroxy-2-thioxo-7-oxa-3-thia-1-azanonyl>benzene (116942-61-1)

Conditions	Yield
for 6h; Ambient temperature;	100%

bis(diphenylphosphinothioyl)disulfide (6079-77-2) + m-phenylenediamine (108-45-2) → 2,4-diaminophanyl diphenylphosphinodithioate + m-phenyleneamine salt of diphenylphosphinodithioic acid

Conditions	Yield
In benzene Heating;	A 92.3% B 100%

2-(vinyloxy)ethyl isothiocyanate (59565-09-2) + m-phenylenediamine (108-45-2) → 1-(2-Vinyloxy-ethyl)-3-{3-[3-(2-vinyloxy-ethyl)-thioureido]-phenyl}-thiourea (140476-03-5)

Conditions	Yield
for 0.0833333h;	100%

m-phenylenediamine (108-45-2) + 4-methoxy-aniline (104-94-9) → (E)-4-(2-(4-methoxyphenyl)diazenyl)benzene-1,3-diamine (20311-41-5)

Conditions	Yield
Stage #1: 4-methoxy-aniline With hydrogenchloride; sodium nitrite In water at 0℃; for 0.666667h; Stage #2: m-phenylenediamine With hydrogenchloride In water at 0℃; for 0.5h;	100%
With hydrogenchloride; sodium nitrite 1. H2O, 0 deg C; 2. 0 deg C, 2 h; Yield given. Multistep reaction;

m-phenylenediamine (108-45-2) + aniline (62-53-3) → (E)-4-(2-phenyldiazenyl)benzene-1,3-diamine

Conditions	Yield
Stage #1: aniline With hydrogenchloride; sodium nitrite In water at 0℃; for 0.666667h; Stage #2: m-phenylenediamine With hydrogenchloride In water at 0℃; for 0.5h;	100%

m-phenylenediamine (108-45-2) + sulfanilamide (63-74-1) → (E)-4-(2-(4-sulfonamido)diazenyl)benzene-1,3-diamine (103-12-8)

Conditions	Yield
Stage #1: sulfanilamide With hydrogenchloride; sodium nitrite In water at 0℃; for 0.666667h; Stage #2: m-phenylenediamine With hydrogenchloride In water at 0℃; for 0.5h;	100%

4-iodo-2-methylaniline (13194-68-8) + m-phenylenediamine (108-45-2) → (E)-4-(2-(4-iodo-2-methylphenyl)diazenyl)benzene-1,3-diamine

Conditions	Yield
Stage #1: 4-iodo-2-methylaniline With hydrogenchloride; sodium nitrite In water at 0℃; for 0.666667h; Stage #2: m-phenylenediamine With hydrogenchloride In water at 0℃; for 0.5h;	100%

3-iodo-4-methylaniline (35944-64-0) + m-phenylenediamine (108-45-2) → (E)-4-(2-(3-iodo-4-methylphenyl)diazenyl)benzene-1,3-diamine

Conditions	Yield
Stage #1: 3-iodo-4-methylaniline With hydrogenchloride; sodium nitrite In water at 0℃; for 0.666667h; Stage #2: m-phenylenediamine With hydrogenchloride In water at 0℃; for 0.5h;	100%

m-phenylenediamine (108-45-2) + 4-methoxy-2-nitroaniline (96-96-8) → (E)-4-(2-(4-methoxy-2-nitrophenyl)diazenyl)benzene-1,3-diamine

Conditions	Yield
Stage #1: 4-methoxy-2-nitroaniline With hydrogenchloride; sodium nitrite In water at 0℃; for 0.666667h; Stage #2: m-phenylenediamine With hydrogenchloride In water at 0℃; for 0.5h;	100%

4-chloro-7-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidine + m-phenylenediamine (108-45-2) → N1-(7-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzene-1,3-diamine

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one Heating;	100%

2,4-dichloro-N-(2-chloro-6-methylphenyl)pyrimidine-5-carboxamide + m-phenylenediamine (108-45-2) → 4-((3-aminophenyl)amino)-2-chloro-N-(2-chloro-6-methylphenyl)pyrimidine-5-carboxamide

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In butan-1-ol at 20 - 90℃; for 1h;	100%

4-chlorophthalic anhydride (118-45-6) + m-phenylenediamine (108-45-2) → 1,3-bis[N-(4-chlorophthalimidio)]benzene (148935-94-8)

Conditions	Yield
Sodium phenylphosphinate In methoxybenzene at 200℃; under 760.051 - 1824.12 Torr; for 2 - 7h; Conversion of starting material;	99.44%
In glycerol at 150℃; for 15h;	55.3%
In 1,2-dichloro-benzene at 20 - 180℃; for 32h;

m-phenylenediamine (108-45-2) + Hexafluoroacetone (684-16-2) → 1,3-bis-(1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propyl)-4,6-phenylenediamine

Conditions	Yield
With 1,1,1,3',3',3'-hexafluoro-propanol; trifluoroacetic acid at 80℃; for 24h;	99.2%

2-diethylaminoethylisothiocyanate (32813-52-8) + m-phenylenediamine (108-45-2) → 1,3-bis-1-<(N,N-diethylamino)ethyl>thioureido>benzene (137697-51-9)

Conditions	Yield
In 1,4-dioxane for 3h; Heating;	99%

di-tert-butyl dicarbonate (24424-99-5) + m-phenylenediamine (108-45-2) → (3-aminophenyl)carbamic acid tert-butyl ester (68621-88-5)

Conditions	Yield
In dichloromethane at 20℃; for 18h; Cooling with ice;	99%
Stage #1: di-tert-butyl dicarbonate; m-phenylenediamine In dichloromethane at 20℃; for 18h; Stage #2: With sodium carbonate In water; ethyl acetate	93%
In tetrahydrofuran at 20℃; for 24h;	92%

m-phenylenediamine (108-45-2) + cis-1,2,3,6-tetrahydrophthalic anhydride (935-79-5) + trans-4,5-dibromocyclohexane-1,2-dicarboxylic anhydride → 6-{3-[(4,5-dibromo-2-carboxy-cyclohexanecarbonyl)-amino]-phenylcarbamoyl}-cyclohex-3-enecarboxylic acid

Conditions	Yield
In acetone at 20℃; for 12h;	99%

m-phenylenediamine (108-45-2) + cis-1,2,3,6-tetrahydrophthalic anhydride (935-79-5) → cis-4-cyclohexene-1,2-dicarboxylic acid N-(m-aminophenyl)amide

Conditions	Yield
In acetone	99%

m-phenylenediamine (108-45-2) + Diethyl carbonate (105-58-8) → N-ethyl-1,3-benzenediamine (50617-74-8)

Conditions	Yield
With zeolite NaY for 2h; Heating;	99%

m-phenylenediamine (108-45-2) + diisopropyl-carbodiimide (693-13-0) → C20H36N6

Conditions	Yield
With [Li(THF)(DME)]3La[μ-η2η1(iPrN)2C(NC6H4p-Cl)]3 at 25℃; for 2h; Inert atmosphere;	99%
With C36H52N5O4Si2Yb In neat at 60℃; for 0.5h; Inert atmosphere;	93%
[{Me2Si(C5Me4)(NPh)}Y(CH2SiMe3)(thf)2] In benzene at 80℃; for 1h;

maleopimaric acid + m-phenylenediamine (108-45-2) → C30H38N2O4

Conditions	Yield
With pyridine for 5h; Reflux;	99%

m-phenylenediamine (108-45-2) + 6-chloro-N,N'-bis-(4-pyrazol-1-yl-phenyl)-[1,3,5]triazine-2,4-diamine → N-3-aminophenyl-N',N"-bis(4-pyrazol-1-ylphenyl)-1,3,5-triazine-2,4,6-triamine (1607446-25-2)

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 140℃; under 760.051 Torr; for 0.166667h; Inert atmosphere; Microwave irradiation;	99%

m-phenylenediamine (108-45-2) + 2-bromobenzoic acid chloride (7154-66-7) → N,N'-(1,3-phenylene)bis(2-bromobenzamide)

Conditions	Yield
With sodium hydrogencarbonate In dichloromethane at 0 - 20℃;	99%

m-phenylenediamine (108-45-2) + Thioctic acid (1077-28-7, 62-46-4) → C14H20N2OS2

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide	99%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0℃; Inert atmosphere;	99%

3-hydroxy-2-naphthoyl chloride (1734-00-5) + m-phenylenediamine (108-45-2) → N,N'-bis-(3-hydroxy-[2]naphthoylamino)-benzene (2808-08-4)

Conditions	Yield
With thionyl chloride In 1-methyl-pyrrolidin-2-one at 10 - 20℃; for 2h;	98.5%
With thionyl chloride In 1-methyl-pyrrolidin-2-one at 10 - 20℃; for 2.5h;

m-phenylenediamine (108-45-2) + methanesulfonyl chloride (124-63-0) → 3-(methylsulfonamido)aniline (37045-73-1)

Conditions	Yield
With calcium bicarbonate; magnesium hydrogencarbonate; sodium dodecyl-sulfate; sodium carbonate; calcium chloride; magnesium chloride In water at -8 - 30℃; for 13.5h; Reagent/catalyst; Temperature;	98.5%

Upstream product

• 100-25-4 1,4-DINITROBENZENE 

Downstream Products

• 70865-29-1 disodium 4-[[5-(aminocarbonyl)-1-ethyl-1,6-dihydro-2-hydroxy-4-methyl-6-oxo-3-pyridyl]azo]-6-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzene-1,3-disulphonate 
• 367-25-9 2,4-Difluoroaniline 
• 372-18-9 1,3-Difluorobenzene 
• 1937-37-7 Direct Black 38 
• 6473-13-8 DIRECT BLACK 22 
• 73398-40-0 disodium 4-[[5-(aminocarbonyl)-1-ethyl-2-hydroxy-4-methyl-6-oxopiperidin-3-yl]azo]-6-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzene-1,3-disulphonate 
• 102-28-3 N1-(3-Aminophenyl)acetamide 
• 532-82-1 Basic Orange 2 
• 6428-31-5 Direct Black 19 
• 99576-15-5 Acid Black 210 
• 541-73-1 1,3-Dichlorobenzene 
• 157577-99-6 Acid Black 234 
• 6428-27-9 disodium 4-[[2,4-diamino-5-[(3-sulphonatophenyl)azo]phenyl]azo]-2-[[2,6-dihydroxy-3-[(4-nitrophenyl)azo]phenyl]azo]benzenesulphonate 
• 86386-73-4 Fluconazole 
• 57131-19-8 Direct Black 166 
• 8003-62-1 disodium 3-[[4-[[4-amino-6(or 7)-sulphonatonaphthyl]azo]phenyl]azo]-6-[(2,4-diaminophenyl)azo]-4-hydroxynaphthalene-2-sulphonate 
• 108-46-3 Resorcinol 
• 61703-11-5 Disperse Red 74 
• 10114-58-6 Basic Brown 1 
• 99-98-9 N,N-Dimethyl-1,4-phenylenediamine 
• 8005-77-4 BismarkbrownG 

Recommend Products

• 6265-21-0  3-[(2-hydroxy-ethyl)amino]aniline 
• 75-21-8  oxirane 
• 108-45-2  m-phenylenediamine 
• 90434-85-8  2-(3-amino-anilino)-ethanethiol 
• 420-12-2  thirane 
• 19840-99-4  7-amino-4-methylcarbostyril 
• 674-82-8  4-methyleneoxetan-2-one 
• 31992-43-5  1-(3-aminophenyl)pyrrolidin-2-one 
• 96-48-0  4-butanolide 
• 1003-29-8  2-pyrrole aldehyde 
• 109-09-1  2-chloropyridine 
• 114841-03-1  (2Z)-4-[(3-aminophenyl)amino]-4-oxo-2-butenoic acid 
• 108-31-6  maleic anhydride 
• 79461-25-9  N,N'-m-phenylenedisuccinamic acid 

Related news

Self-assembly of m-Phenylenediamine (cas 108-45-2) and polyoxometalate into hollow-sphere and core-in-hollow-shell nanostructures for selective adsorption of dyes08/21/2019

Supramolecular self-assembly is an effective method to assemble organic and inorganic units into various hierarchical structures with excellent properties and is widely used in material and life science. In this article, the self-assembled hollow-sphere and core-in-hollow-shell nanostructures co...detailed

ArticleDetermination and correlation solubility of m-Phenylenediamine (cas 108-45-2) in (methanol, ethanol, acetonitrile and water) and their binary solvents from 278.15 K to 313.15 K☆08/20/2019

In this study, the solubility of m-phenylenediamine in four pure solvents (methanol, ethanol, acetonitrile and water) and three binary solvent (methanol + water), (ethanol + water) and (acetonitrile + water) systems were determined in the temperature ranging from 278.15 K to 313.15 K by using th...detailed