103029-09-0

Basic information

• Product Name: 5-(2-chlorophenyl)imidazolidine-2,4-dione
• Synonyms: 5-(2-chlorophenyl)imidazolidine-2,4-dione
• CAS NO: 103029-09-0
• Molecular Weight: 210.62
• Mol File: 103029-09-0.mol

Chemical Properties

• CAS DataBase Reference: 5-(2-chlorophenyl)imidazolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-chlorophenyl)imidazolidine-2,4-dione(103029-09-0)
• EPA Substance Registry System: 5-(2-chlorophenyl)imidazolidine-2,4-dione(103029-09-0)

Safety Data

• Hazardous Substances Data: 103029-09-0(Hazardous Substances Data)

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 151-50-8 potassium cyanide 
• 506-87-6 ammonium carbonate 
• 124-38-9 carbon dioxide 
• 13312-84-0 2-chloromandelonitrile 

Downstream Products

• 86169-24-6 2-amino-(2-chlorophenyl)ethanoic acid 
• 103866-45-1 5-(2-chlorophenyl)-2-ethoxy-2-imidazolin-4-one 
• 86169-24-6 (R)-(2-chlorophenyl)glycine 
• 87066-47-5 3-(2-chlorophenyl)-2,3,5,6-tetrahydro-1H-imidazo<1,2-a>imidazol-2-one 
• 87066-60-2 2-(2-chloroethyl)amino-5-(2-chlorophenyl)-2-imidazolin-4-one 
• 103866-50-8 5-(2-chlorophenyl)-2-(2-hydroxyethyl)amino-2-imidazolin-4-one 
• 103830-69-9 2-(2-chlorophenyl)-2,3,5,6-tetrahydro-1H-imidazo<1,2-a>imidazol-3-one hydrochloride 
• 92874-69-6 DL-Benzyloxycarbonylamino-<2-chlor-phenyl>-essigsaeure 

Relevant articles and documents

Method for continuously and quickly preparing DL-phenylglycine and analogue thereof

The invention provides a method for continuously and quickly preparing DL-phenylglycine and an analogue thereof. The method comprises the steps of adding 2-hydroxyl-phenylacetonitrile and an analoguethereof (cyanohydrin for short) and an aqueous ammonium bicarbonate solution into a microchannel reactor for a reaction, controlling the reaction temperature to be 80-130 DEG C, and controlling the reaction pressure to be 0.5-2.0 MPa, wherein the standing time of the reactants in a microchannel is 1-8 min, and an aqueous solution of 5-phenyl-hydantoin and an analogue thereof (hydantoin for short)is obtained; adding the hydantoin and alkali into the microchannel reactor for a reaction, controlling the reaction temperature to be 120-200 DEG C, and controlling the reaction pressure to be 1.0-3.5MPa, wherein the standing time of the reactants in the microchannel is 1-8 min, and then a saline solution of phenylglycine and an analogue thereof is obtained; conducting acidification neutralization and crystallization to obtain the phenylglycine and the analogue thereof. According to the method, the microchannel reactor is adopted, the reaction time is greatly shorted, the reaction speed is increased, pyrolysis and polymerization of the cyanohydrin are reduced, no by-products are generated, the products are high in yield, clean and environmentally friendly, and the production cost is lowered.

HAT INHIBITORS AND METHODS FOR THEIR USE

Compounds having a structure of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b, R3a, R3b, R3c, R4a, R4b, R5, R6, Z and X are as defined herein are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.

A one-pot synthesis of 5,5-disubstituted hydantoin derivatives using magnetic Fe3O4 nanoparticles as a reusable heterogeneous catalyst

A facile and rapid method for the one-pot synthesis of 5,5-disubstituted hydantoins in the presence of magnetic Fe3O4 nanoparticles has been developed. The multicomponent reactions of carbonyl compounds (aldehydes and ketones), potassium cyanide and ammonium carbonate were carried out under solvent-free conditions to obtain various hydantoin derivatives. The magnetic catalyst could be readily separated by an external magnet from the reaction mixture. This procedure has many advantages, such as the use of a reusable magnetic catalyst, high yields, short reaction times, simplicity and very easiness with implementing the methodology.

Production of ring-substituted D-phenylglycines by microbial or enzymatic hydrolysis/deracemisation of the corresponding DL-hydantoins

A series of 17 ring-mono and -disubstituted D-phenylglycine derivatives was prepared in high enantiomeric purity by enzymatic hydrolysis and deracemisation of the corresponding DL-hydantoins, using D-hydantoinase activities of microorganisms or purified enzymes, followed by diazotation of the resulting N-carbamyl-D-amino acids. No significant L-hydantoinase activity was found to produce the corresponding L-enantiomers.