10321-25-2Relevant articles and documents
A facile synthesis of α,α′-bis(substituted benzylidene) cycloalkanones catalyzed by KF/Al2O3 under ultrasound irradiation
Li, Ji-Tai,Yang, Wen-Zhi,Chen, Guo-Feng,Li, Tong-Shuang
, p. 2619 - 2625 (2003)
The condensation of the cyclopentanone or cyclohexanone with aromatic aldehydes catalyzed by KF/Al2O3 in MeOH under ultrasound irradiation, result the corresponding 2,5-bis(substituted benzylidene) cyclopentanones or 2,6-bis(substituted benzylidene) cyclohexanones in good yields.
Copper triflate-catalyzed cross-aldol condensation: A facile synthesis of α,α′-bis(substituted benzylidene) cycloalkanones
Li, Jianjun,Su, Weike,Li, Ning
, p. 3037 - 3043 (2005)
A facile, efficient, and clean procedure is described for synthesis of α,α′-bis(substituted benzylidene) cycloalkanones with good yields by the reaction of cycloalkanones with aromatic aldehydes using Cu(OTf)2 as catalyst. The catalyst was easily recovered and reused without loss of activity. Copyright Taylor & Francis, Inc.
Design, characterization, and use of N,N-diethyl-N-sulfoethanaminium hydrogen sulfate {[Et3N-SO3H]HSO4} as a novel and highly efficient catalyst for preparation of α,α′-bis(arylidene)cycloalkanones
Ahmadi, Salimeh,Zare, Abdolkarim,Aali-Hosaini, Mina,Maghsoudi, Maryam,Izadpanah, Shadi,Parhami, Abolfath,Merajoddin, Maria
, p. 6245 - 6253 (2016)
Abstract: The aim of this work is to introduce a novel and attractive protic acidic ionic liquid as catalyst for organic synthesis. To achieve this aim, N,N-diethyl-N-sulfoethanaminium hydrogen sulfate {[Et3N-SO3H]HSO4} was prepared by reaction of NEt3 with ClSO3H and then with H2SO4. The novel acidic ionic liquid was identified by Fourier-transform infrared (FT-IR), 1H nuclear magnetic resonance (NMR), 13C NMR, and mass spectroscopies. Its catalytic activity was then examined in the cross-aldol condensation reaction of arylaldehydes with cycloalkanones under solvent-free conditions, obtaining α,α′-bis(arylidene)cycloalkanones in high yield after short reaction time. Graphical Abstract: [Figure not available: see fulltext.]
Aldol condensations catalyzed by PEG400 and anhydrous K2CO 3 without solvent
Cao, Yu-Qing,Dai, Zhi,Zhang, Rui,Chen, Bao-Hua
, p. 1045 - 1049 (2005)
Aldol condensations of aromatic aldehydes with ketones under solvent-free conditions to synthesize α,β-unsaturated ketones in good to excellent yields using PEG400 and powdered anhydrous K2CO3 as catalysts at 90°C and 120°C are described. Copyright Taylor & Francis, Inc.
Animal bone meal as an efficient catalyst for crossed-aldol condensation
Riadi,Mamouni,Azzalou,Boulahjar,Abrouki,El Haddad,Routier,Guillaumet,Lazar
, p. 6715 - 6717 (2010)
α,α′-Bis(substituted benzylidene)cycloalkanones were efficiently prepared from cycloalkanones and benzaldehydes in water by using animal bone meal (ABM) or ABM modified as a catalyst. It is shown that ABM modified can be quantitatively recovered and be reused effectively for many times. A comparison of catalytic activity of these catalysts is discussed.
Aldol condensation of cycloalkanones with aromatic aldehydes catalysed with TiCi3(SO3CF3)
Iranpoor,Zeynizadeh,Aghapour
, p. 554 - 555 (1999)
Efficient cross-aldol condensation of cyclopentanone, cyclohexanone and 1-indanone with various aromatic aldehydes is catalysed with TiCl3(SO3CF3) at room temperature in excellent yields.
KF-melamine formaldehyde resin (KF-MFR) as a versatile and efficient heterogeneous reagent for aldol condensation of aldehydes and ketones under microwave irradiation
Rezaie, Ramin,Heidary, Mohammad,Soltani Rad, Mohammad Navid,Behrouz, Somayeh
, p. 1221 - 1226 (2011)
KF-Melamine formaldehyde resin (KF-MFR) was demonstrated to be a highly efficient heterogenious catalyst for cross-aldol condensation under microwave irradiation. In this synthesis, various aldehydes and ketones were condensed together in the presence of supported KF on melamine-formaldehyde resin to afford different chalcone derivatives in good to excellent yields. KF-MFR proved to have unique termal and chemical resistance and can be reused for many consecutive runs without remarkable loss in catalytic activity. Copyright
Synthesis, characterization, crystal structure of novel bis-thiomethylcyclohexanone derivatives and their inhibitory properties against some metabolic enzymes
Bi?er, Abdullah,Taslimi, Parham,Yakal?, Gül,Gül?in, Ilhami,Serdar Gültekin, Mehmet,Turgut Cin, Günseli
, p. 393 - 404 (2019)
In this study, a series of novel bis-thiomethylcyclohexanone compounds (3a–3j) were synthesized by the addition of thio-Michael to the bis-chalcones under mild reaction conditions. The bis-thiomethylcyclohexanone derivatives (bis-sulfides) were characterized by 1H NMR, 13C NMR, FTIR and elemental analysis techniques. Furthermore, the molecular and crystal structures of 3h, 3i and 3j compounds were determined by single crystal X-ray diffraction studies. In this study, X-ray crystallography provided an alternative and often-complementary means for elucidating functional groups at the enzyme inhibitory site. Acetylcholinesterase (AChE) is a member of the hydrolase protein super family and has a significant role in acetylcholine-mediated neurotransmission. Here, we report the synthesis and determining of novel bis-thiomethylcyclohexanone compounds based hybrid scaffold of AChE inhibitors. The newly synthesized bis-thiomethylcyclohexanone compounds showed Ki values of in range of 39.14–183.23 nM against human carbonic anhydrase I isoenzyme (hCA I), 46.03–194.02 nM against human carbonic anhydrase II isoenzyme (hCA II), 4.55–32.64 nM against AChE and 12.77–37.38 nM against butyrylcholinesterase (BChE). As a result, novel bis-thiomethylcyclohexanone compounds can have promising anti Alzheimer drug potential and record novel hCA I, and hCA II enzymes inhibitor.
Solvent-free crossed aldol condensation of cyclic ketones with aromatic aldehydes assisted by microwave irradiation
Esmaeili, Abbas A.,Tabas, Mehri Salimi,Nasseri, Mohammad A.,Kazemi, Foad
, p. 571 - 576 (2005)
A fast alumina-promoted crossed aldol-condensation reaction of aldehydes and cyclic ketones under microwave irradiation is described. This process is simple, efficient, and environmentally benign and proceeds in fairly high yield without any self-condensation. Springer-Verlag 2005.
Synthesis, docking, and in vitro studies of some substituted bischalcones on acid and alkaline phosphatases
Singh, Mamta,Raghav, Neera
, p. 1781 - 1788 (2014)
A series of bischalcones was synthesized and screened for their effect on acid and alkaline phosphatases. In addition, molecular modeling and docking of these compounds into alkaline phosphatase using iGemdock was performed in order to predict the affinity and orientation of the designed compounds at the active site and was compared with the established inhibitor levamisole. The iGemdock docking fitness resulted in decrease in total energy (ranging from -75.50 to -100.84) for all the synthesized compounds which were less than levamisole (-50.69) revealing higher binding with the enzyme. The compounds were synthesized by Clasien-Schimdt condensation and their effect was observed on the activity of acid and alkaline phosphatases. The results showed that synthesized bischalcones were inhibitory to alkaline phosphatases, whereas an activating effect was observed on the activity of acid phosphatase. The type of inhibition and Ki values of bischalcones on alkaline phosphatase were also determined. Springer Science+Business Media 2013.
