103750-03-4

Basic information

• Product Name: 5-Maleimidovalericacid-NHS
• Synonyms: 5-Maleimidovalericacid-NHS;5-Maleimidopentanoic acid-NHS ester;1H-Pyrrole-1-pentanoicacid, 2,5-dihydro-2,5-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester;2,5-dioxopyrrolidin-1-yl 5-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)
• CAS NO: 103750-03-4
• Molecular Formula: C₁₃H₁₄N₂O₆
• Molecular Weight: 294.26006
• Mol File: 103750-03-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Solubility: Soluble in DMSO, DCM, DMF
• CAS DataBase Reference: 5-Maleimidovalericacid-NHS(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Maleimidovalericacid-NHS(103750-03-4)
• EPA Substance Registry System: 5-Maleimidovalericacid-NHS(103750-03-4)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 103750-03-4(Hazardous Substances Data)

Usage

Description

5-Maleimido-pentanoic NHS ester contains a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Chemical Properties

White powder

Upstream product

• 91420-49-4 tert-butyl 2-hydroxyethylpropionate 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 57078-99-6 5-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)pentanoic acid 

Downstream Products

• 143230-95-9 C₄₅H₅₅F₂N₇O₁₀ 

Relevant articles and documents

Conjugate of cytotoxin molecule and cell binding receptor molecule

A conjugate of a strong cytotoxin molecule and a cell binding receptor molecule has a structure shown in a molecular formula (I), wherein T, L, m, n, -----, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and R13 are defined in the text. The conjugate is used for treating cancer, immunological diseases and infectious diseases.

CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS

A conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule having a formula (I), wherein T, L, m, n, Y, R1, R2, R3, R4, R5, R6, R7, R8, Rsu

Syntheses of siderophore-drug conjugates using a convergent thiol-maleimide system

Three siderophore-drug conjugates (sideromycins) were synthesized by preparation of a maleimide linked derivative of the siderophore desferrioxamine B and reacting the corresponding Ga3+-complex with freshly prepared thiol-containing antibiotics: loracarbef, ciprofloxacin, and nadifloxacin. The conjugates and their synthetic precursors were tested against a broad panel of bacteria and were found to display Gram-positive selective, growth inhibitory activity (μM), indicating that this approach is suitable for the convergent syntheses and screening of novel sideromycins.