1041013-49-3Relevant articles and documents
A novel method to enable SNAr reaction of aminopyrrolopyrazoles
Guo, Chuangxing,Dong, Liming,Marakovits, Joseph,Kephart, Susan
, p. 1692 - 1696 (2011)
Here we report mild, environmentally-friendly reaction conditions which enable the addition-elimination SNAr reaction between weakly reactive substrates - an aminopyrrolopyrazole template and several substituted pyrimidines. The method was developed during our efforts to synthesize a series of novel P21-activated kinase (PAK) inhibitors.