104296-35-7

Basic information

• Product Name: ETHYL 5-(2-FURYL)-1-METHYL-1H-PYRAZOLE-3-CARBOXYLATE
• Synonyms: ETHYL 5-(2-FURYL)-1-METHYL-1H-PYRAZOLE-3-CARBOXYLATE;Ethyl 5-(2-furyl)-1-methyl-1H-pyrazole-3-carboxylate 97%;Ethyl 5-(furan-2-yl)-1-Methyl-1H-pyrazole-3-carboxylate;ethyl 5-(furan-2-yl)-1-methylpyrazole-3-carboxylate
• CAS NO: 104296-35-7
• Molecular Formula: C11H12N2O3
• Molecular Weight: 220.22
• Mol File: 104296-35-7.mol

Chemical Properties

• Melting Point: 62.5-64.5
• Boiling Point: 352.4°Cat760mmHg
• Flash Point: 166.9°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 3.85E-05mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ETHYL 5-(2-FURYL)-1-METHYL-1H-PYRAZOLE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 5-(2-FURYL)-1-METHYL-1H-PYRAZOLE-3-CARBOXYLATE(104296-35-7)
• EPA Substance Registry System: ETHYL 5-(2-FURYL)-1-METHYL-1H-PYRAZOLE-3-CARBOXYLATE(104296-35-7)

Safety Data

• Hazardous Substances Data: 104296-35-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 5-(2-FURYL)-1-METHYL-1H-PYRAZOLE-3-CARBOXYLATE is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and chemical properties make it a valuable building block in the development of new drugs.
Used in Chemical Research:
In the field of chemical research, ETHYL 5-(2-FURYL)-1-METHYL-1H-PYRAZOLE-3-CARBOXYLATE serves as a subject for studying the properties and reactions of furanone and pyrazole derivatives. This helps in understanding the broader chemical behavior of these types of compounds and their potential applications in various industries.
Used in Material Science:
ETHYL 5-(2-FURYL)-1-METHYL-1H-PYRAZOLE-3-CARBOXYLATE is used as a component in the development of new materials with specific properties. Its incorporation into materials can lead to novel applications in areas such as electronics, coatings, and advanced materials.

InChI:InChI=1/C11H12N2O3/c1-3-15-11(14)8-7-9(13(2)12-8)10-5-4-6-16-10/h4-7H,3H2,1-2H3

Upstream product

• 36983-35-4 ethyl 4-(furan-2-yl)-2,4-dioxobutyrate 
• 60-34-4 methylhydrazine 
• 1192-62-7 1-(2-furyl)-1-ethanone 
• 412304-91-7 ethyl 4-(2-furyl)-2,4-dioxobutanoate 

Downstream Products

• 1078709-28-0 N-(4-tert-butylbenzyl)-4-chloro-3-formyl-1-methyl-1H-pyrazole-5-carboxamide 
• 1078709-27-9 N-(4-tert-butylbenzyl)-4-chloro-3-ethoxycarbonyl-1-methyl-1H-pyrazole-5-carboxamide 

Relevant articles and documents

7H-PYRROLO[2,3-D]PYRIMIDINE-4-AMINE DERIVATIVE

The present invention provides a novel compound inhibiting EGFR or a salt of the compound. According to one embodiment of the present invention, provided is a compound represented by general formula (I) or a pharmaceutically acceptable salt thereof.

Synthesis of fluorinated and nonfluorinated tebufenpyrad analogues for the study of anti-angiogenesis MOA

In this contribution we report the synthesis of fluorinated and nonfluorinated tebufenpyrad analogues to explore potential druglike properties through the phenotypic screening as part of the Lilly Open Innovation Drug Discovery (OIDD) program.

Improved regioselectivity in pyrazole formation through the use of fluorinated alcohols as solvents: Synthesis and biological activity of fluorinated tebufenpyrad analogs

(Chemical Equation Presented) The preparation of N-methylpyrazoles is usually accomplished through reaction of a suitable 1,3-diketone with methylhydrazine in ethanol as the solvent. This strategy, however, leads to the formation of regioisomeric mixtures of N-methylpyrazoles, which sometimes are difficult to separate. We have determined that the use of fluorinated alcohols such as 2,2,2-trifluoroethanol (TFE) and 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as solvents dramatically increases the regioselectivity in the pyrazole formation, and we have used this modification in a straightforward synthesis of fluorinated analogs of Tebufenpyrad with acaricide activity.

Synthesis of new fluorinated tebufenpyrad analogs with acaricidal activity through regioselective pyrazole formation

(Chemical Equation Presented) In previous studies, our group has shown that the use of fluorinated alcohols such as trifluoroethanol (TFE) and hexafluoroisopropanol (HFIP) as solvents dramatically increases the regioselectivity in the pyrazole formation from 1,3-diketone with methylhydrazine. We have now applied this synthetic method to the preparation of new fluorinated pyrazoles, which have then been used as synthetic intermediates in the preparation of fluorinated analogs of Tebufenpyrad, a commercial acaricide. These compounds display a strong acaricidal activity that is either comparable to or better than that of the commercial compound.