36983-35-4

Basic information

• Product Name: ethyl 4-(furan-2-yl)-2,4-dioxobutyrate
• Synonyms: ethyl 4-(furan-2-yl)-2,4-dioxobutyrate
• CAS NO: 36983-35-4
• Molecular Weight: 210.186
• Mol File: 36983-35-4.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: ethyl 4-(furan-2-yl)-2,4-dioxobutyrate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-(furan-2-yl)-2,4-dioxobutyrate(36983-35-4)
• EPA Substance Registry System: ethyl 4-(furan-2-yl)-2,4-dioxobutyrate(36983-35-4)

Safety Data

• Hazardous Substances Data: 36983-35-4(Hazardous Substances Data)

Upstream product

• 1192-62-7 1-(2-furyl)-1-ethanone 
• 95-92-1 oxalic acid diethyl ester 

Downstream Products

• 996-98-5 oxalic acid hydrazide 
• 92352-24-4 5-(furan-2-yl)-1H-pyrazole-3-carboxylic acid hydrazide 
• 635704-01-7 6-[2-(2-furyl)-2-oxoethyl]-3-methylsulfanyl-1,2,4-triazin-5(2H)-one 
• 139062-24-1 3-[(4-Chloro-phenyl)-hydrazono]-4-furan-2-yl-2,4-dioxo-butyric acid ethyl ester 
• 139062-26-3 4-Furan-2-yl-3-[(4-nitro-phenyl)-hydrazono]-2,4-dioxo-butyric acid ethyl ester 
• 33545-40-3 5-furan-2-yl-isoxazole-3-carboxylic acid ethyl ester 
• 34020-22-9 ethyl 5-(furan-2-yl)-1H-pyrazole-3-carboxylate 
• 104296-35-7 3-(ethoxycarbonyl)-5-(2-furyl)-1-methylpyrazole 
• 101351-11-5 3-ethoxycarbonyl-5-(2-furyl)-1-phenylpyrazole 
• 107275-28-5 4ξ-benzoyloxy-4ξ-[2]furyl-2-oxo-but-3-enoic acid ethyl ester 
• 102467-00-5 4-(furan-2-carbonyl)-1,5-diphenyl-pyrrolidine-2,3-dione 
• 876728-41-5 [5-(furan-2-yl)-1-methyl-1H-pyrazol-3-yl]methanol 

Relevant articles and documents

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ATF6 INHIBITORS AND USES THEREOF

Compounds as inhibitors of Activating Transcription Factor 6 (ATF6) are provided. The compounds may find use as therapeutic agents for the treatment of diseases or disorders mediated by ATF6 and may find particular use in the treatment of viral infections, neurodegenerative diseases, vascular diseases, or cancer.

Diphenylpyrazoles as replication protein A inhibitors

Replication Protein A is the primary eukaryotic ssDNA binding protein that has a central role in initiating the cellular response to DNA damage. RPA recruits multiple proteins to sites of DNA damage via the N-terminal domain of the 70 kDa subunit (RPA70N). Here we describe the optimization of a diphenylpyrazole carboxylic acid series of inhibitors of these RPA-protein interactions. We evaluated substituents on the aromatic rings as well as the type and geometry of the linkers used to combine fragments, ultimately leading to submicromolar inhibitors of RPA70N protein-protein interactions.