1056901-62-2 Usage
Uses
AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor.
Biological Activity
at13148 is a novel, oral and atp-competitive inhibitor of multi-agc kinase with ic50 values of 38nm, 8nm, 3nm, 63nm and 4nm for akt, p70s6 kinase, pka, sgk and rho kinase, respectively [1].
in vitro
studies, at13148 has been reported to inhibit activity of agc kinases which including akt, p70s6 kinase, pka, sgk and rho kinase with the ic50 values of 38nm, 8nm, 3nm, 63nm and 4nm, respectively. in addition, at13148 has been revealed to inhibit proliferation with gi50 values of 1.54μm, 1.59μm, 1.82μm, 2.65μm and 3.77μm in mes-sa, bt474, hct-116, a549 and sk-ov-3 cell lines, respectively.
in vivo
studies, at13148 has shown the antitumor activity in multiple human tumor xenograft models including pten-deficient mes-sa human uterine sarcoma, her2-positive, pik3ca-mutant bt474 human breast cancer xenografts [1].
references
[1] yap ta1, walton mi, grimshaw km, te poele rh, eve pd, valenti mr, de haven brandon ak, martins v, zetterlund a, heaton sp, heinzmann k, jones ps, feltell re, reule m, woodhead sj, davies tg, lyons jf, raynaud fi, eccles sa, workman p, thompson nt, garrett md. at13148 is a novel, oral multi-agc kinase inhibitor with potent pharmacodynamic and antitumor activity. clin cancer res. 2012 jul 15;18(14):3912-23.
Check Digit Verification of cas no
The CAS Registry Mumber 1056901-62-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,5,6,9,0 and 1 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1056901-62:
(9*1)+(8*0)+(7*5)+(6*6)+(5*9)+(4*0)+(3*1)+(2*6)+(1*2)=142
142 % 10 = 2
So 1056901-62-2 is a valid CAS Registry Number.
1056901-62-2Relevant articles and documents
PHARMACEUTICAL COMPOUNDS
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, (2008/12/07)
The invention provides a composition comprising (S) 2-amino-1-(4-chloro-phenyl)- 1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, wherein the composition is either substantially free of (R) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)- phenyl]-ethanol or the composition contains a mixture of the (S) and (R) enantiomers in which the (S) enantiomer predominates. Also provided are processes for the preparation of the (S) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H- pyrazol-4-yl)-phenyl]-ethanol, novel process intermediates and methods for making the novel process intermediates.
