10578-79-7 Usage
Description
N(4)-methylcytidine (m4C) is a modified nucleoside found in RNAs, particularly abundant in transfer RNAs (tRNAs). It is a product of cytidine methylation, a chemical reaction that enhances the stability and functionality of RNA molecules. The presence of m4C in RNA is associated with various biological processes, such as translation accuracy, gene expression, and the response to cellular stress. Furthermore, cytidine methylation is linked to several diseases, including cancer and neurological disorders. Its chemical structure consists of a cytidine molecule with a methyl group attached to the nitrogen atom at position 4 of the cytosine ring.
Uses
Used in Biomedical Research:
N(4)-methylcytidine is used as a biomarker for studying the role of RNA methylation in various biological processes. The presence and distribution of m4C in RNA can provide insights into translation accuracy, gene expression regulation, and cellular stress response mechanisms.
Used in Diagnostic Applications:
N(4)-methylcytidine is used as a diagnostic marker for identifying and monitoring diseases associated with RNA methylation, such as cancer and neurological disorders. The detection of altered m4C levels in RNA can aid in the early diagnosis and treatment of these conditions.
Used in Drug Development:
N(4)-methylcytidine is used as a target for developing therapeutic agents that modulate RNA methylation. By targeting enzymes involved in the methylation process, these drugs may have potential applications in treating diseases where RNA methylation plays a critical role, such as cancer and neurological disorders.
Used in Synthetic Biology:
N(4)-methylcytidine is used as a building block for engineering RNA molecules with specific properties. By incorporating m4C into RNA structures, researchers can create RNA molecules with enhanced stability, functionality, and the ability to interact with other cellular components in a controlled manner. This can have applications in areas such as RNA-based therapeutics and RNA-based sensors.
Check Digit Verification of cas no
The CAS Registry Mumber 10578-79-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,5,7 and 8 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 10578-79:
(7*1)+(6*0)+(5*5)+(4*7)+(3*8)+(2*7)+(1*9)=107
107 % 10 = 7
So 10578-79-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H15N3O5/c1-11-6-2-3-13(10(17)12-6)9-8(16)7(15)5(4-14)18-9/h2-3,5,7-9,14-16H,4H2,1H3,(H,11,12,17)
10578-79-7Relevant articles and documents
Synthesis and solution conformation studies of the modified nucleoside N4,2′-O-dimethylcytidine (m4Cm) and its analogues
Mahto, Santosh K.,Chow, Christine S.
, p. 8795 - 8800 (2008/12/23)
The dimethylated ribosomal nucleoside m4Cm and its monomethylated analogues Cm and m4C were synthesized. The conformations (syn vs anti) of the three modified nucleosides and cytidine were determined by CD and 1D NOE difference spectroscopy. The ribose sugar puckers were determined by the use of proton coupling constants. The position of modification (e.g., O vs N methylation) was found to have an effect on the sugar pucker of cytidine.
Reductive monoalkylation of aromatic amines via amidine intermediates
Zhang, Jianxing,Chang, Hui-Min,Kane, Robert R.
, p. 643 - 645 (2007/10/03)
The convenience and efficiency of using amidines as intermediates in the reductive monoalkylation of aromatic amines has been demonstrated. This monoalkylation can be performed as either a two-step synthesis or a one-pot procedure. Several examples are presented which clearly demonstrate the utility of this new method for the methylation or ethylation of aromatic amines, including unprotected nucleosides.
Transformations of thiopyrimidine and thiopurine nucleosides following oxidation with dimethyldioxirane
Saladino, Raffaele,Mincione, Enrico,Crestini, Claudia,Mezzetti, Maurizio
, p. 6759 - 6780 (2007/10/03)
A general and convenient method for the synthesis of several pyrimidine and purine nucleosides by selective oxidation of thionucleosides with dimethyldioxirane is reported. Thioketo moieties in the C-4 position of the pyrimidine ring, and in the C-6, and C-8 positions of the purine ring are the domain of oxidative nucleophilic substitution. Thioketo moieties in the C-2 position of both purine and pyrimidine rings are the domain of desulfurization or formation of disulfides.
