N4-Methylcytidine

Base Information

• Chemical Name: N4-Methylcytidine
• CAS No.: 10578-79-7
• Molecular Formula: C10H15 N3 O5
• Molecular Weight: 257.246
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID20147340
• Nikkaji Number: J359.361D
• Mol file: 10578-79-7.mol

Synonyms:N(4)-methylcytidine

Chemical Property of N4-Methylcytidine

Chemical Property:

• Vapor Pressure: 2.82E-12mmHg at 25°C
• Melting Point: 202-203 °C(Solv: ethanol (64-17-5))
• Boiling Point: 504.2°Cat760mmHg
• PKA: 13.48±0.70(Predicted)
• Flash Point: 258.7°C
• PSA: 116.84000
• Density: 1.69g/cm³
• LogP: -2.03050
• Storage Temp.: 2-8°C(protect from light)
• Solubility.: Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• XLogP3: -1.7
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 257.10117059
• Heavy Atom Count: 18
• Complexity: 397

Purity/Quality:

98%,99%, ^*data from raw suppliers

N4-Methylcytidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1=NC(=O)N(C=C1)C2C(C(C(O2)CO)O)O
• Isomeric SMILES: CNC1=NC(=O)N(C=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O

Technology Process of N4-Methylcytidine

There total 36 articles about N4-Methylcytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2',3',5'-tri-O-acetyl-N4-methyl-cytidine (111426-20-1) → 4-methylamino-1-(β-D-ribofuranosyl)pyrimidin-2(1H)-one (10578-79-7)

Guidance literature:

With ammonia; In methanol; at 20 ℃;

DOI:10.1016/j.bmc.2008.09.016

Reference yield: 97.0%

methylamine (74-89-5) + 4-O-(4-nitrophenyl)uridine (189005-88-7) → 4-methylamino-1-(β-D-ribofuranosyl)pyrimidin-2(1H)-one (10578-79-7)

Guidance literature:

In ethanol; for 1.5h; Ambient temperature;

DOI:10.1080/07328319708002521

Reference yield: 96.0%

2',3',5'-tri-O-benzoyl-N4-methylcytidine → 4-methylamino-1-(β-D-ribofuranosyl)pyrimidin-2(1H)-one (10578-79-7)

Guidance literature:

With ammonia; In methanol; Ambient temperature;

DOI:10.1080/15257779508012548

upstream raw materials:

1-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-4-thiouracil

methylamine

methylamine hydrochloride

Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-[2-oxo-4-(pyridin-3-yloxy)-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester

Downstream raw materials:

CYTIDINE

Refernces

• 1、 -. "Anti-HCV nucleoside derivatives". . . Retrieved 2008/06/13.
• 2、 Miah, Anwar,Reese, Colin B.,Song, Quanlai. "Convenient intermediates for the preparation of C-4 modified derivatives of pyrimidine nucleosides". . p. 53 - 65. Retrieved 2007/10/03.