10593-85-8

Basic information

• Product Name: HOMOCYSTEINE THIOLACTONE
• Synonyms: Butyricacid, 2-amino-4-mercapto-, g-(thio lactone) (6CI); (2-Oxotetrahydrothiophen-3-yl)amine; (?à)-Homocysteine thiolactone; 3-Aminotetrahydrothiophen-2-one;ADT; Butanoic acid, 2-amino-4-mercapto-, g-(thio lactone); DL-3-Aminotetrahydro-2-thiophenone;DL-Homocysteine thiolactone; Homocysteine thiolactone; Homocysteine-g-thiolactone
• CAS NO: 10593-85-8
• Molecular Formula: C₄H₇NOS
• Molecular Weight: 117.17
• Mol File: 10593-85-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 253.8°Cat760mmHg
• Flash Point: 107.3°C
• Appearance: /
• Density: 1.269g/cm³
• Vapor Pressure: 0.0179mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: HOMOCYSTEINE THIOLACTONE(CAS DataBase Reference)
• NIST Chemistry Reference: HOMOCYSTEINE THIOLACTONE(10593-85-8)
• EPA Substance Registry System: HOMOCYSTEINE THIOLACTONE(10593-85-8)

Safety Data

• Hazardous Substances Data: 10593-85-8(Hazardous Substances Data)

Usage

General Description

Homocysteine thiolactone is a reactive intermediate of homocysteine, an amino acid derived from the metabolism of methionine. It is a cyclic thioester compound that has been found to be toxic to cells and tissues in high concentrations. Homocysteine thiolactone is known to cause protein damage and modification, leading to a variety of adverse effects on cellular function. It has been implicated in the development of cardiovascular disease, neurodegenerative disorders, and other pathological conditions. Additionally, homocysteine thiolactone has been shown to induce oxidative stress and inflammation, contributing to the progression of various diseases. Efforts to understand and mitigate the effects of homocysteine thiolactone on cellular function and health continue to be a focus of research in the fields of biochemistry and medicine.

InChI:InChI=1/C4H7NOS/c5-3-1-2-7-4(3)6/h3H,1-2,5H2

Upstream product

• 39837-09-7 DL-N-benzoylhomocysteine thiolactone 
• 462-10-2 DL-homocystine 
• 38869-92-0 3,6-bis-(2-mercapto-ethyl)-piperazine-2,5-dione 
• 1017-76-1 S-benzyl homocysteine 
• 59-51-8 DL-methionine 
• 7689-60-3 S-benzyl-L-homocysteine 

Downstream Products

• 38869-96-4 (3RS)-3-[N-(Benzyloxycarbonyl)amino]-2-oxo-tetrahydrothiophene 
• 105441-18-7 2-[[N-(tetrahydro-2-oxo-thien-3-yl)amino]carbonyl]benzoic acid 
• 84023-71-2 N-(o-hydroxybenzylidene)-2-oxotetrahydro-3-thiophenine 
• 60305-58-0 L-[S-methyl-11C]methionine 
• 454-29-5 2-amino-4-mercaptobutyric acid 
• 84611-23-4 erdosteine 
• 6027-13-0 L-homocysteine 
• 202284-85-3 (S)-N-butyryl homocysteine thiolactone 
• 89807-04-5 D-[S-methyl-11C]methionine 
• 88328-24-9 3-{[1-Phenyl-meth-(E)-ylidene]-amino}-dihydro-thiophen-2-one 
• 88328-25-0 2,4-diphenyl-3-(3'-tetrahydro-2-oxo-thienyl)-5,5-spiro(3',3'-tetrahydro thiophen-2-one) 
• 3860-79-5 Homocystin-1,1-dioxid 

Related news

N-Acetylcysteine supplementation decreased brain lipid and protein oxidations produced by experimental HOMOCYSTEINE THIOLACTONE (cas 10593-85-8) exposure: Relevance to neurodegeneration08/15/2019

High levels of homocysteine (Hcy) have neurotoxic effects. Homocysteine thiolactone (HcyT), a thioester of Hcy, plays a role in Hcy-induced toxicity. In this study, effects of HcyT treatment (500 mg/kg body weight/day in drinking water) for 6 weeks on serum Hcy levels and brain prooxidant-antiox...detailed

Application of GC–MS technique for the determination of HOMOCYSTEINE THIOLACTONE (cas 10593-85-8) in human urine08/14/2019

It is well established that homocysteine thiolactone (HTL) is associated with some health disorders, including cardiovascular diseases. HTL is a by-product of sulfur metabolic cycle. So far, its presence has been confirmed in human plasma and urine. It has been also shown that a vast majority of...detailed

Relevant articles and documents

Immonological detection of the homocystamide adduct and a thiolactone immunoassay for endogeneous homocysteine

An antibody specific for homocystamide adducts is disclosed. In a preferred embodiment of the present invention, the antibody is used to evaluate the level of homocysteine in a biological sample.