1062222-96-1Relevant articles and documents
Label-free fluorescent probing of G-quadruplex formation and real-time monitoring of DNA folding by a quaternized tetraphenylethene salt with aggregation-induced emission characteristics
Hong, Yuning,Haeussler, Matthias,Lam, Jacky W.Y.,Li, Zhen,Sin, King Keung,Dong, Yongqiang,Tong, Hui,Liu, Jianzhao,Qin, Anjun,Renneberg, Reinhard,Tang, Ben Zhong
, p. 6428 - 6437 (2008)
Biosensing processes such as molecular beacons require non-trivial effort to covalently label or mark biomolecules. We report here a label-free DNA assay system with a simple dye with aggregation-induced emission (AIE) characteristics as the fluorescent bioprobe. 1,1,2,2-Tetrakis[4-(2-bromoethoxy)phenyl]ethene is nonemissive in solution but becomes highly emissive when aggregated. This AIE effect is caused by restriction of intramolecular rotation, as verified by a large increase in the emission intensity by increasing viscosity and decreasing temperature of the aqueous buffer solution of 1,1,2,2-tetrakis[4-(2- triethylammonioethoxy)phenyl]ethene tetrabromide (TTAPE). When TTAPE is bound to a guanine-rich DNA strand (G1) via electrostatic attraction, its intramolecular rotation is restricted and its emission is turned on. When a competitive cation is added to the G1 solution, TTAPE is detached and its emission is turned off. TTAPE works as a sensitive poststaining agent for Polyacrylamide) gel electrophoresis (PAGE) visualization of G1. The dye is highly affinitive to a secondary structure of G1 called the G-quadruplex. The bathochromic shift involved in the G1 folding process allows spectral discrimination of the G-quadruplex from other DNA structures. The strong affinity of TTAPE dye to the G-quadruplex structure is associated with a geometric fit aided by the electrostatic attraction. The distinct AIE feature of TTAPE enables real-time monitoring of folding process of G1 in the absence of any pre-attached fluorogenic labels on the DNA strand. TTAPE can be used as a K+ ion biosensor because of its specificity to K+-induced and -stabilized quadruplex structure.
Cucurbit[7]uril-tetraphenylethene host-guest system induced emission activity
Jiang, Rong,Wang, Shuang,Li, Jinping
, p. 4478 - 4482 (2016)
A host-guest complex was successfully constructed from cucurbit[7]uril (Q[7]) and quaternary ammonium-modified tetraphenylethene derivative, 1,1,2,2-tetrakis{2-[2-(N,N,N-trimethylammonium)ethyoxyl]phenyl}-tetraphenylethene bromide (TAPET), and characteriz
Tetraphenyl ethylene bridged tetrabenzimidazole salt and preparation method and application thereof
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Paragraph 0018; 0019, (2018/11/27)
The invention discloses tetraphenyl ethylene bridged tetrabenzimidazole salt and a preparation method and an application thereof. According to the invention, 4,4'-dihydroxy benzophenone is taken as araw material, is subjected to Mc Murry reaction to obtai
Water-soluble AIE luminogens for monitoring and retardation of fibrillation of amyloid proteins
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Page/Page column 73; 74, (2016/04/20)
Compounds that exhibit aggregation induced emission (AIE), and more particularly to water-soluble conjugated polyene compounds that exhibit aggregation induced emission. The conjugated polyene compounds can be used as bioprobes for DNA detection, G-quadru
Investigating the effects of side chain length on the AIE properties of water-soluble TPE derivatives
Dong, Yifan,Wang, Weilun,Zhong, Cewen,Shi, Jianbing,Tong, Bin,Feng, Xiao,Zhi, Junge,Dong, Yuping
supporting information, p. 1496 - 1500 (2014/03/21)
The emissive properties of fluorophores in aggregated state are important for the development of bio-sensors or bio-imaging reagents. So three water-soluble TPE derivatives with different lengths of side chains have been synthesized and we investigated the effects of side chains on aggregation-induced emission (AIE) properties in the aggregated states. The results indicate that side chains on the fluorophores play a pivotal role in their emission in aggregated state mediated by heparin or solid state, because the coplanarity of these TPE derivatives was affected by side chains. The rates of radiative decay kf and non-radiative decay knr have been obtained through the quantum yields and lifetime, and a larger k f and smaller knr were present for compound TPE-C4N, suggesting that the aggregated TPE-C4N should posses the most remarkable fluorescent property.
WATER-SOLUBLE AIE LUMINOGEN FOR MONITORING AND RETARDATION OF AMYLOID FIBRILLATION OF INSULIN
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, (2012/07/14)
The presently described subject matter is directed to a water-soluble conjugated polyene compound and the derivatives thereof that exhibit aggregation induced emission, as well as any water dispersible, fluorescent, polymeric microparticles, nanoparticles, and/or pharmaceutical composition comprising the water-soluble conjugated polyene compound and/or the derivatives thereof. Also provided are methods of making and using the compound, derivatives and particles of the presently described subject matter. The presently described water-soluble conjugated polyene compound are useful as bioprobes for the detection of biomacromolecules, in the manufacture of sensors, in monitoring and retarding formation of amyloid protein fibril in vitro and in vivo, and in developing anti-cancer drugs.