107401-74-1Relevant articles and documents
Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases
Schonbrunn, Ernst,Betzi, Stephane,Alam, Riazul,Martin, Mathew P.,Becker, Andreas,Han, Huijong,Francis, Rawle,Chakrasali, Ramappa,Jakkaraj, Sudhakar,Kazi, Aslamuzzaman,Sebti, Said M.,Cubitt, Christopher L.,Gebhard, Anthony W.,Hazlehurst, Lori A.,Tash, Joseph S.,Georg, Gunda I.
, p. 3768 - 3782 (2013/06/27)
Cyclin-dependent kinases (CDKs) are serine/threonine protein kinases that act as key regulatory elements in cell cycle progression. We describe the development of highly potent diaminothiazole inhibitors of CDK2 (IC50 = 0.0009-0.0015 μM) from a
Studies on the Synthesis of 5-Acyl-2,4-diaminothiazoles from Amidinothioureas
Rajasekharan, K. N.,Nair, K. P.,Jenardanan, G. C.
, p. 353 - 355 (2007/10/02)
1-Alkyl or aryl-3-amidinothioureas with or without substituents on the amidino moiety react with α-haloketones to yield 5-acyl-2,4-diaminothiazoles.