AKOS USSH-4110200

Base Information

• Chemical Name: AKOS USSH-4110200
• CAS No.: 107401-74-1
• Molecular Formula: C₁₁H₁₁N₃OS
• Molecular Weight: 233.294
• Mol file: 107401-74-1.mol

Synonyms:AKOS USSH-4110200;CHEMBRDG-BB 7904092;[4-AMINO-2-(METHYLAMINO)-1,3-THIAZOL-5-YL](PHENYL)METHANONE;[4-amino-2-(methylamino)-1,3-thiazol-5-yl](phenyl)methanone(SALTDATA: FREE)

Chemical Property of AKOS USSH-4110200

Chemical Property:

• Vapor Pressure: 1.87E-08mmHg at 25°C
• Boiling Point: 454.7°C at 760 mmHg
• Flash Point: 228.8°C
• PSA: 96.25000
• Density: 1.356g/cm³
• LogP: 2.65220

Purity/Quality:

98% ^*data from raw suppliers

[4-Amino-2-(methylamino)-1,3-thiazol-5-yl](phenyl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AKOS USSH-4110200

There total 3 articles about AKOS USSH-4110200 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

CYANAMID (420-04-2) + methyl thioisocyanate (556-61-6) + α-bromoacetophenone (70-11-1) → (4-Amino-2-methylamino-thiazol-5-yl)-phenyl-methanone (107401-74-1)

Guidance literature:

CYANAMID; methyl thioisocyanate; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.25h;

α-bromoacetophenone; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jm301234k

Reference yield:

C11H14N4OS*BrH → (4-Amino-2-methylamino-thiazol-5-yl)-phenyl-methanone (107401-74-1)

Guidance literature:

With triethylamine; In ethanol; acetone; Yield given; 60 deg C; r.t., 1 h;

DOI:10.1055/s-1986-31634

Reference yield:

α-bromoacetophenone (70-11-1) → (4-Amino-2-methylamino-thiazol-5-yl)-phenyl-methanone (107401-74-1)

Guidance literature:

Multi-step reaction with 2 steps

1: acetone; ethanol / 1 h / Ambient temperature

2: triethylamine / acetone; ethanol / 60 deg C; r.t., 1 h

With triethylamine; In ethanol; acetone;

DOI:10.1055/s-1986-31634

upstream raw materials:

α-bromoacetophenone

CYANAMID

methyl thioisocyanate

Refernces

• 1、 Rajasekharan, K. N.,Nair, K. P.,Jenardanan, G. C.. "Studies on the Synthesis of 5-Acyl-2,4-diaminothiazoles from Amidinothioureas". . p. 353 - 355. Retrieved 2007/10/02.