108392-02-5 Usage
Description
1,2-DI[CIS-9-OCTADECENOYL]-SN-GLYCERO-3-PHOSPHATE SODIUM SALT is a complex lipid molecule that plays a crucial role in various biological processes, particularly in the formation and function of cell membranes. It is characterized by its unique structure, which includes a glycerol backbone esterified with two cis-9-octadecenoyl chains and a phosphate group, with the entire molecule being a sodium salt.
Uses
Used in Pharmaceutical Industry:
1,2-DI[CIS-9-OCTADECENOYL]-SN-GLYCERO-3-PHOSPHATE SODIUM SALT is used as a key component in the formulation of liposomes for drug delivery. Its unique structure allows for the creation of stable and biocompatible vesicles that can encapsulate a wide range of therapeutic agents, enhancing their solubility, stability, and targeted delivery to specific cells or tissues.
Used in Drug Delivery and Liposome Preparation:
1,2-DI[CIS-9-OCTADECENOYL]-SN-GLYCERO-3-PHOSPHATE SODIUM SALT is used as an essential ingredient in the method for preparing liposomes comprising ultrasound reactive microbubbles. These microbubbles are utilized in drug delivery systems to improve the efficiency of therapeutic agents by enhancing their penetration and uptake by target cells or tissues. The presence of this molecule in the liposome composition contributes to the overall stability and functionality of the drug delivery system.
Check Digit Verification of cas no
The CAS Registry Mumber 108392-02-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,3,9 and 2 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 108392-02:
(8*1)+(7*0)+(6*8)+(5*3)+(4*9)+(3*2)+(2*0)+(1*2)=115
115 % 10 = 5
So 108392-02-5 is a valid CAS Registry Number.
InChI:InChI=1/C39H73O8P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(40)45-35-37(36-46-48(42,43)44)47-39(41)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h17-20,37H,3-16,21-36H2,1-2H3,(H2,42,43,44);/b19-17+,20-18+;
108392-02-5Relevant articles and documents
The development of improved cationic lipids for gene transfer into cystic fibrosis airway epithelial cells
Harris,Marshall,Lee,Siegel,Mcneilly,Yew,Nietupski,Nichols,Cherry,Wan,Jiang,Lane,Rowe,Scheule,Smith,Cheng
, p. 289 - 292 (1996)
In an effort to improve the efficiency of cationic lipid mediated gene transfer, over 90 novel cationic lipids of diverse structural types were synthesized and evaluated in vitro. Four cationic lipids derived from phospholipids were examined. The most promising cationic lipid formulations were tested in vivo by intranasal or transtracheal instillation into the lungs of BALB/c mice. The most active formulations gave CAT reporter gene expression levels which are greater than 500 fold over that which could be attained using free DNA alone. Certain cationic lipid formulations have been shown to facilitate substantial expression of the CFTR (cystic fibrosis transmembrane conductance regulator) gene in vitro as determined by the SPQ and Ussing Chamber assays.