109062-95-5Relevant articles and documents
ADENYLYL CYCLASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND METHOD OF USE THEREOF
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Paragraph 0253, (2018/01/20)
The present invention relates to novel adenine based inhibitors of adenylyl cyclase of the formula: wherein X, L, R1, R2, R5 are those defined herein. Compounds of the present invention are useful to treat cardiovascular diseases. The present invention also relates to a method of preventing heart failure by administering an effective amount of compound according to the invention following vascular injury and reperfusion therapy.
Total synthesis of the polyenoyltetramic acid polycephalin C
Longbottom, Deborah A.,Morrison, Angus J.,Dixon, Darren J.,Ley, Steven V.
, p. 6955 - 6966 (2007/10/03)
The total synthesis of the polyenoyltetramic acid polycephalin C is described. Key steps of the synthesis include a double Swern oxidation, double Takai reaction and a double Stille reaction. In addition, the absolute stereochemistry of the ring junction
Conformative coupling of two conformational molecular switches
Karle, Michael,Bockelmann, Dirk,Schumann, Dirk,Griesinger, Christian,Koert, Ulrich
, p. 4546 - 4549 (2007/10/03)
Passing on information. Two conformational switches, decalin units, were coupled to a 14-membered bislactam ring (see formula, TBDPS=tert-butyldiphenylsilyl). Removal of a bisacetal clamp on the left side of the molecule resulted in a double ring-flip of
Total synthesis of polycephalin C and determination of the absolute configurations at the 3′′,4′′ ring junction
Longbottom, Deborah A.,Morrison, Angus J.,Dixon, Darren J.,Ley, Steven V.
, p. 2786 - 2790 (2007/10/03)
Only through total synthesis could the absolute configuration of the 3′′R,4′′R ring junction of the polyenoltetramic acid polycephalin C (1) be unambiguously established. Key features of the synthesis include a double Swern oxidation, double Stille coupli
Synthesis and biological evaluation of a monocyclic, fully functional analogue of compactin
Heathcock,Davis,Hadley
, p. 197 - 202 (2007/10/02)
Compound 8, a monocyclic analogue of compactin, has been prepared and its efficacy as an inhibitor of 3-hydroxy-3-methylglutarylcoenzyme A reductase (HMGR) evaluated. The synthesis (Schemes I and II) requires seven steps starting with di-(-)-menthyl fumar
ASYMMETRIC DIELS-ALDER REACTION. COOPERATIVE BLOCKING EFFECT IN ORGANIC SYNTHESIS
Furuta, Kyoji,Iwanaga, Kiyoshi,Yamamoto, Hisashi
, p. 4507 - 4510 (2007/10/02)
Remarkably high diastereoselectivity is observed in the organoaluminium catalyzed asymmetric Diels-Alder reaction of (-)-dimenthyl fumarate.