109142-44-1Relevant articles and documents
Synthesis and cycloaddition reactions of 2,3,4,5-tetrahydropyrazine 1-oxide
Wazeer, Mohammed I.M,Perzanowski, Herman P,Qureshi, Sajid I,Al-Murad, Mohammad B,Asrof Ali, Sk
, p. 7229 - 7236 (2000)
The stereochemistry and reactivity of the cycloaddition reactions of a heterocyclic nitrone, 2,3,4,5,-tetrahydropyrazine 1-oxide, have been studied. The heterocyclic nitrone is found to be more reactive than its carbocyclic counterpart. The nitrone underwent regio- and stereo-selective cycloaddition reaction with several alkenes to afford bicyclic isoxazolidines efficiently. Barriers to nitrogen inversion in the cycloadducts have been determined. (C) 2000 Elsevier Science Ltd.
Quinolinecarboxylic acid derivatives and antibacterial agent containing the same
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, (2008/06/13)
Novel quinolinecarboxylic derivatives of the formula: STR1 wherein Z is STR2 in which R1 is hydrogen atom or a lower alkyl, R2 is hydrogen atom, hydroxyl or a lower alkyl and R3 is hydrogen atom, hydroxyl or an amino, and
Synthesis of antimicrobial agents. IV. Synthesis of 1-hydroxypiperazine dihydrochloride and its applications to pyridone carboxylic acid antibacterial agents
Uno,Okuno,Taguchi,Iuchi,Kawahata,Sotomura,Tsukamoto
, p. 393 - 396 (2007/10/02)
1-Hydroxypiperazine dihydrochloride 7 was prepared and it was applied to the syntheses of new pyridone carboxylic acid antibacterial agents (PCA-antibacterial agents). 1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(4-hydroxypiperazin-1-yl(-4- oxoquinoline-3-carboxylic acid 13 showed the most potent antibacterial activity.
