1097-51-4

Basic information

• Product Name: 16a,17a-Epoxyprogesterone
• Synonyms: 16,17-Epoxypregn-4-ene-3,20-dione;16-alpha,17-epoxy-pregn-4-ene-20-dione;16-alpha,17-epoxypregn-4-ene-3,20-dione;16,17-EPOXYPROGESTERONE;16,17-ALPHA-EPOXYPROGESTERONE;16a,17a-epoxy-4-pregnen-3,20-dione;16A,17A-EPOXY PROGESTERONE;16ALPHA,17ALPHA-EPOXYPROGESTERONE
• CAS NO: 1097-51-4
• Molecular Formula: C₂₁H₂₈O₃
• Molecular Weight: 328.45
• EINECS: 214-147-5
• Product Categories: Biochemistry;Steroids;Steroids (Others)
• Mol File: 1097-51-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 200C
• Boiling Point: 466.9 °C at 760 mmHg
• Flash Point: 204.4 °C
• Appearance: white crystalline powder
• Density: 1.18 g/cm³
• Vapor Pressure: 6.82E-09mmHg at 25°C
• Refractive Index: 168 ° (C=1, CHCl3)
• Storage Temp.: −20°C
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: 16a,17a-Epoxyprogesterone(CAS DataBase Reference)
• NIST Chemistry Reference: 16a,17a-Epoxyprogesterone(1097-51-4)
• EPA Substance Registry System: 16a,17a-Epoxyprogesterone(1097-51-4)

Safety Data

• WGK Germany: 3
• RTECS: TU5022000
• Hazardous Substances Data: 1097-51-4(Hazardous Substances Data)

Usage

Uses

16α,17α-Epoxyprogesterone is hydrolyzed by Rhizopus nigricans for the synthesis of many steroidal drugs.

InChI:InChI=1/C21H28O3/c1-12(22)21-18(24-21)11-17-15-5-4-13-10-14(23)6-8-19(13,2)16(15)7-9-20(17,21)3/h10,15-18H,4-9,11H2,1-3H3

Upstream product

• 974-23-2 3β-hydroxy-16α,17α-epoxypregn-5-en-20-one 
• 2872-76-6 20α-hydroxy-16α,17α-epoxypregn-4-en-3-one 
• 38521-84-5 3-acetyloxypregna-5,16-diene-20-one 
• 6996-36-7 3β-(toluene-4-sulfonyloxy)-pregna-5,16-dien-20-one 
• 911442-53-0 3β-hydroxypregn-5-ene-16,20-dione 
• 78792-99-1 6β-methoxy-3α,5α-cyclo-pregn-16-en-20-one 
• 979-02-2 16-dehydropregnenolone acetate 
• 1044-90-2 (3β,5α,16α)-16,17-epoxy-3-hydroxypregnan-20-one 
• 1096-38-4 16-dehydroprogesterone 

Downstream Products

• 28018-91-9 16β-Brom-17α-hydroxy-pregnen-(4)-dion-(3,20) 
• 3684-83-1 11α-hydroxy-16α,17α-epoxyprogesterone 
• 1225520-49-9 C₄₂H₅₆O₄S₃ 
• 1225520-55-7 C₄₉H₆₁O₅PS₃ 
• 1225520-41-1 3-thioxo-16α,17α-epoxyprogesterone 
• 3684-84-2 16α,17-epoxypregn-4-ene-3,11,20-trione 
• 570-58-1 5β-17α-hydroxy-preganene-3,20-dione 
• 68-96-2 17-hydroxyprogesterone 
• 1096-38-4 16-dehydroprogesterone 
• 438-07-3 16α-hydroxyprogesterone 
• 152-58-9 Cortexolone 
• 100167-82-6 16α,17α-epoxypregn-4-en-21-ol-3,20-dione 
• 119005-10-6 20,20-dimethoxy-16α,17α-epoxypregn-4-en-21-ol-3-one 

Relevant articles and documents

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New process for synthesizing steroid 3-one-4-ene

The invention discloses a new process for synthesizing steroid 3-one-4-ene. The method comprises the steps: with steroid 3-hydroxy-5-ene as a starting material, in a nonprotic organic solvent, with air or oxygen as an oxidant and with a transition metal nitrate and a 2,2,6,6-tetramethylpiperidine-1-oxyl free radical or an analogue thereof as catalysts, oxidizing to obtain the steroid 3-one-4-ene. The method has the advantages of high yield, mild reaction conditions, easily controlled operation, low energy consumption, low cost, and safety; and the whole process is friendly to the environment, and is suitable for industrialization.

STEROID TRANSFORMATIONS. 187. MICROBIAL CONVERSION OF 3β-HYDROXY-5α-H-PREGNANES TO THEIR Δ4-3-KETO-9α-HYDROXY DERIVATIVES

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