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Amadis Chemical offer CAS#152-58-9;CAT#A883892
Cas No: 152-58-9
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
11-Desoxy-17-hydroxycorticosterone
Cas No: 152-58-9
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
Pharmaceutical Grade CAS 152-58-9 with competitive price
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USD $ 139.0-210.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier
Competitive Price CORTEXOLONE CAS152-58-9
Cas No: 152-58-9
No Data 100 Gram 50 Metric Ton/Day Hebei miaobian Biotechnology Co., Ltd Contact Supplier
CORTEXOLONE
Cas No: 152-58-9
No Data 10 Gram Metric Ton/Day Jilin Tely Imp.& Exp.Co., Ltd. Contact Supplier
11-Deoxy-17-Hydroxycorticosterone manufacturer
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CORTEXOLONE cas 152-58-9
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USD $ 10.0-10.0 / Kilogram 1 Kilogram 200 Metric Ton/Month Hebei Guanlang Biotechnology Co., Ltd. Contact Supplier
Pregn-4-ene-3,20-dione,17,21-dihydroxy-
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CORTEXOLONE / high quality
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USD $ 1.0-1.0 / Kilogram 5 Kilogram 100 Kilogram/Week Career Henan Chemical Co Contact Supplier
11-Deoxy Cortisol 152-58-9
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USD $ 1.0-1.0 / Gram 1 Gram 1 Metric Ton/Day PRIME MOLECULAR CO.,LIMITED Contact Supplier

152-58-9 Usage

Uses

Glucocorticoid receptor binding

Chemical Properties

Crystalline Solid

152-58-9 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (C1478)  Cortexolone  >98.0%(HPLC) 152-58-9 1g 660.00CNY Detail

152-58-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 11-deoxycortisol

1.2 Other means of identification

Product number -
Other names CORTEXOLONE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:152-58-9 SDS

152-58-9Synthetic route

(8R,9S,10R,13S,14S)-10,13-Dimethyl-17-[1-tripropylsilanyloxy-eth-(Z)-ylidene]-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
110801-53-1

(8R,9S,10R,13S,14S)-10,13-Dimethyl-17-[1-tripropylsilanyloxy-eth-(Z)-ylidene]-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one

Cortexolone
152-58-9

Cortexolone

Conditions
ConditionsYield
With potassium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid88%
cortexolone 21-acetate
640-87-9

cortexolone 21-acetate

Cortexolone
152-58-9

Cortexolone

Conditions
ConditionsYield
With water; potassium carbonate In methanol at 20℃; for 3h; Inert atmosphere;85%
With methanol; potassium hydrogencarbonate
17,21-diacetoxy-4-pregnene-3,20-dione
1807-15-4

17,21-diacetoxy-4-pregnene-3,20-dione

Cortexolone
152-58-9

Cortexolone

Conditions
ConditionsYield
With potassium hydroxide In methanol Ambient temperature;80%
With potassium hydroxide
C25H37BrNO2(1+)*Cl(1-)

C25H37BrNO2(1+)*Cl(1-)

Cortexolone
152-58-9

Cortexolone

Conditions
ConditionsYield
With water; potassium carbonate In acetone at 20℃; for 72h; Inert atmosphere;70%
21-bromo-17α-hydroxy-4-pregnene-3,20-dione
20380-17-0

21-bromo-17α-hydroxy-4-pregnene-3,20-dione

Cortexolone
152-58-9

Cortexolone

Conditions
ConditionsYield
With potassium carbonate for 0.166667h; Heating;68%
With water; potassium carbonate In acetone at 20℃; for 0.5h; Inert atmosphere;57%
cortexolone 21-acetate
640-87-9

cortexolone 21-acetate

A

Cortexolone
152-58-9

Cortexolone

B

9α-hydroxycortexolone
566-12-1

9α-hydroxycortexolone

Conditions
ConditionsYield
With disodium hydrogenphosphate; potassium dihydrogenphosphate; D-glucose; menadione; corn-steep liquor In water; N,N-dimethyl-formamide at 28℃; for 40h; Rhodococcus sp.;A 30%
B 50%
pyridine
110-86-1

pyridine

17.20βF-dihydroxy-3-oxo-pregnen-(4)-al-(21)
59005-57-1

17.20βF-dihydroxy-3-oxo-pregnen-(4)-al-(21)

Cortexolone
152-58-9

Cortexolone

21-Hydroxyprogesterone
64-85-7

21-Hydroxyprogesterone

Cortexolone
152-58-9

Cortexolone

Conditions
ConditionsYield
mit Hilfe von Trichothecium roseum;
21-Hydroxyprogesterone
64-85-7

21-Hydroxyprogesterone

A

Cortexolone
152-58-9

Cortexolone

B

6β,21-dihydroxypregna-4-en-3,20-dione
298-65-7

6β,21-dihydroxypregna-4-en-3,20-dione

Conditions
ConditionsYield
mit Hilfe von Trichothecium roseum;
17.20βF-dihydroxy-3-oxo-pregnen-(4)-al-(21)
59005-57-1

17.20βF-dihydroxy-3-oxo-pregnen-(4)-al-(21)

Cortexolone
152-58-9

Cortexolone

Conditions
ConditionsYield
With pyridine
Progesterone
57-83-0

Progesterone

A

HYDROCORTISONE
50-23-7

HYDROCORTISONE

B

17-hydroxyprogesterone
68-96-2

17-hydroxyprogesterone

C

21-Hydroxyprogesterone
64-85-7

21-Hydroxyprogesterone

D

Corticosterone
50-22-6

Corticosterone

E

Cortexolone
152-58-9

Cortexolone

Conditions
ConditionsYield
With glucose-6-phosphate dehydrogenase; phosphate buffer; air; α-D-glucose 6-phosphate; midterm female fetal human adrenal tissue; NADP; magnesium chloride at 37℃; for 2h; Product distribution; <3H>labeled;A 36.3 % Chromat.
B n/a
C n/a
D 4.7 % Chromat.
E n/a
Progesterone
57-83-0

Progesterone

A

17-hydroxyprogesterone
68-96-2

17-hydroxyprogesterone

B

21-Hydroxyprogesterone
64-85-7

21-Hydroxyprogesterone

C

Corticosterone
50-22-6

Corticosterone

D

Cortexolone
152-58-9

Cortexolone

Conditions
ConditionsYield
With glucose-6-phosphate dehydrogenase; phosphate buffer; air; α-D-glucose 6-phosphate; midterm female fetal human kidney tissue; NADP; magnesium chloride at 37℃; for 2h; Product distribution; <3H>labeled;A 2.3 % Chromat.
B 21.1 % Chromat.
C n/a
D 32.5 % Chromat.
17-hydroxyprogesterone
68-96-2

17-hydroxyprogesterone

A

HYDROCORTISONE
50-23-7

HYDROCORTISONE

B

testosterone
58-22-0

testosterone

C

Androstenedione
63-05-8

Androstenedione

D

Cortexolone
152-58-9

Cortexolone

Conditions
ConditionsYield
With D-glucose 6-phosphate; sporadic adrenal pheochromocytomas; oxygen; NADP; glucose 6-phosphate dehydrogenase at 37℃; for 1h; Product distribution; <4-14C>-labeled;A 20.6 % Turnov.
B 1.1 % Turnov.
C 2.3 % Turnov.
D 14.8 % Turnov.
17-hydroxyprogesterone
68-96-2

17-hydroxyprogesterone

Cortexolone
152-58-9

Cortexolone

Conditions
ConditionsYield
With α-D-glucose 6-phosphate; 21-hydroxylase from human fetal adrenals; glucose-6-phosphate-dehydrogenase; potassium chloride; 2-amino-2-hydroxymethyl-1,3-propanediol; magnesium chloride Equilibrium constant; interaction with cytochrome P-450 obtained from microsomes and mitochondria from human fetal adrenals in dependence on conc.; apparent spectral dissociation const.; inhibition by danazol;
With CYP21 Enzymatic reaction;
With recombinant human cytochrome P450 21A2; water In aq. phosphate buffer at 37℃; Enzymatic reaction;
With wild-type human cytochrome P450 21A2 Kinetics; Reagent/catalyst; Enzymatic reaction;
methanol
67-56-1

methanol

16α,17α-epoxyprogesterone
1097-51-4, 16356-47-1

16α,17α-epoxyprogesterone

A

Cortexolone
152-58-9

Cortexolone

B

20,20-dimethoxy-16α,17α-epoxypregn-4-en-21-ol-3-one
119005-10-6

20,20-dimethoxy-16α,17α-epoxypregn-4-en-21-ol-3-one

Conditions
ConditionsYield
With potassium hydroxide; [bis(acetoxy)iodo]benzene at 20℃; for 7h;A 0.08 g
B 0.15 g
16α,17α-epoxyprogesterone
1097-51-4, 16356-47-1

16α,17α-epoxyprogesterone

A

17-hydroxyprogesterone
68-96-2

17-hydroxyprogesterone

B

Cortexolone
152-58-9

Cortexolone

C

16α,17α-epoxypregn-4-en-21-ol-3,20-dione
100167-82-6

16α,17α-epoxypregn-4-en-21-ol-3,20-dione

Conditions
ConditionsYield
With potassium hydroxide; [bis(acetoxy)iodo]benzene In methanol at 20℃; for 8h;A 0.02 g
B 0.02 g
C 0.19 g
Pregnenolone
145-13-1

Pregnenolone

A

HYDROCORTISONE
50-23-7

HYDROCORTISONE

B

testosterone
58-22-0

testosterone

C

Androstenedione
63-05-8

Androstenedione

D

21-Hydroxyprogesterone
64-85-7

21-Hydroxyprogesterone

E

Corticosterone
50-22-6

Corticosterone

F

Cortexolone
152-58-9

Cortexolone

G

DHEA

DHEA

Conditions
ConditionsYield
With D-glucose 6-phosphate; sporadic adrenal pheochromocytomas; oxygen; NADP; glucose 6-phosphate dehydrogenase at 37℃; for 1h; Product distribution; <4-14C>-labeled;A 12.6 % Turnov.
B 0.9 % Turnov.
C 1.9 % Turnov.
D 2.4 % Turnov.
E 6.8 % Turnov.
F 2.3 % Turnov.
G n/a
C26H37NO5

C26H37NO5

Cortexolone
152-58-9

Cortexolone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 80 percent
2: hydrolysis
3: 80 percent / KOH / methanol / Ambient temperature
View Scheme
C28H39NO7
84542-27-8

C28H39NO7

Cortexolone
152-58-9

Cortexolone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrolysis
2: 80 percent / KOH / methanol / Ambient temperature
View Scheme
17-Hydroxypregnenolone
387-79-1

17-Hydroxypregnenolone

Cortexolone
152-58-9

Cortexolone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 10 percent / CuBr2 / tetrahydrofuran / 2 h / Heating
2: 65 percent / 8 N CrO3 / acetone / 0.08 h
3: 68 percent / aq. K2CO3 / 0.17 h / Heating
View Scheme
21-bromo-3β,17α-dihydroxy-5-pregnen-20-one
2827-40-9

21-bromo-3β,17α-dihydroxy-5-pregnen-20-one

Cortexolone
152-58-9

Cortexolone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 65 percent / 8 N CrO3 / acetone / 0.08 h
2: 68 percent / aq. K2CO3 / 0.17 h / Heating
View Scheme
16-dehydroprogesterone
1096-38-4

16-dehydroprogesterone

Cortexolone
152-58-9

Cortexolone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 79 percent / RhCl(PPh3)3
2: 88 percent / mCPBA, KHCO3
View Scheme
17-hydroxy-20βF-acetoxy-3-oxo-pregnen-(4)-al-(21)

17-hydroxy-20βF-acetoxy-3-oxo-pregnen-(4)-al-(21)

Cortexolone
152-58-9

Cortexolone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aqueous methanol.KHCO3
2: pyridine
View Scheme
Progesterone
57-83-0

Progesterone

A

21-Hydroxyprogesterone
64-85-7

21-Hydroxyprogesterone

B

2β,16β-hydroxyprogesterone
1334177-12-6

2β,16β-hydroxyprogesterone

C

Cortexolone
152-58-9

Cortexolone

E

2beta-Hydroxyprogesterone
604-29-5, 604-28-4, 123287-83-2

2beta-Hydroxyprogesterone

Conditions
ConditionsYield
With Bacillus megaterium cytochrome P450 BM3 monooxygenase (V78L/A82F/F87A)-expressing cells at 25℃; for 24h; diastereoselective reaction;
Progesterone
57-83-0

Progesterone

A

21-Hydroxyprogesterone
64-85-7

21-Hydroxyprogesterone

B

Cortexolone
152-58-9

Cortexolone

D

2beta-Hydroxyprogesterone
604-29-5, 604-28-4, 123287-83-2

2beta-Hydroxyprogesterone

Conditions
ConditionsYield
With Bacillus megaterium cytochrome P450 BM3 monooxygenase (R47Y/T49F/V78T/A82F/F78A)-expressing cells at 25℃; for 24h; diastereoselective reaction;
Progesterone
57-83-0

Progesterone

Cortexolone
152-58-9

Cortexolone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: CYP17A1 / Enzymatic reaction
2: CYP21 / Enzymatic reaction
View Scheme
3-O-ethoxypregnenolone

3-O-ethoxypregnenolone

A

Androstenedione
63-05-8

Androstenedione

B

Cortexolone
152-58-9

Cortexolone

C

R-16α,17-dihydroxy-pregn-4-ene-3,20-dione
595-77-7

R-16α,17-dihydroxy-pregn-4-ene-3,20-dione

D

C21H30O5

C21H30O5

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium tert-butylate; oxygen / tetrahydrofuran; tert-butyl alcohol / 4.67 h / 20 °C
2: acetic acid / methanol / 3 h / 20 °C
3: 1,2-dilauroyl-sn-glicero-3-phosphatidylcholine; zebrafish P450 17A2 enzyme / aq. phosphate buffer; ethanol; dimethyl sulfoxide / 37 °C / pH 7.4 / Enzymatic reaction
4: zebrafish P450 17A1 enzyme; 1,2-dilauroyl-sn-glicero-3-phosphatidylcholine / aq. phosphate buffer / 37 °C / pH 7.4 / Enzymatic reaction
View Scheme
3-O-ethoxypregnenolone

3-O-ethoxypregnenolone

A

Cortexolone
152-58-9

Cortexolone

B

R-16α,17-dihydroxy-pregn-4-ene-3,20-dione
595-77-7

R-16α,17-dihydroxy-pregn-4-ene-3,20-dione

C

C21H30O5

C21H30O5

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium tert-butylate; oxygen / tetrahydrofuran; tert-butyl alcohol / 4.67 h / 20 °C
2: acetic acid / methanol / 3 h / 20 °C
3: 1,2-dilauroyl-sn-glicero-3-phosphatidylcholine; zebrafish P450 17A2 enzyme / aq. phosphate buffer; ethanol; dimethyl sulfoxide / 37 °C / pH 7.4 / Enzymatic reaction
4: 1,2-dilauroyl-sn-glicero-3-phosphatidylcholine; zebrafish b5 enzyme; NADPH-P450 reductase; zebrafish P450 17A2 enzyme / aq. phosphate buffer / 37 °C / pH 7.4 / Enzymatic reaction
View Scheme
C23H36O4

C23H36O4

A

Androstenedione
63-05-8

Androstenedione

B

Cortexolone
152-58-9

Cortexolone

C

R-16α,17-dihydroxy-pregn-4-ene-3,20-dione
595-77-7

R-16α,17-dihydroxy-pregn-4-ene-3,20-dione

D

C21H30O5

C21H30O5

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic acid / methanol / 3 h / 20 °C
2: 1,2-dilauroyl-sn-glicero-3-phosphatidylcholine; zebrafish P450 17A2 enzyme / aq. phosphate buffer; ethanol; dimethyl sulfoxide / 37 °C / pH 7.4 / Enzymatic reaction
3: zebrafish P450 17A1 enzyme; 1,2-dilauroyl-sn-glicero-3-phosphatidylcholine / aq. phosphate buffer / 37 °C / pH 7.4 / Enzymatic reaction
View Scheme
Cortexolone
152-58-9

Cortexolone

acetic anhydride
108-24-7

acetic anhydride

cortexolone 21-acetate
640-87-9

cortexolone 21-acetate

Conditions
ConditionsYield
With pyridine at 20℃; for 0.5h;100%
With pyridine
Cortexolone
152-58-9

Cortexolone

21-dehydrohydrocortexolone dimer

21-dehydrohydrocortexolone dimer

Conditions
ConditionsYield
With air; copper diacetate In methanol for 5h;100%
Cortexolone
152-58-9

Cortexolone

pivaloyl chloride
3282-30-2

pivaloyl chloride

17-Hydroxy-21-trimethylacetoxy-4-pregnen-3,20-dion
6920-52-1

17-Hydroxy-21-trimethylacetoxy-4-pregnen-3,20-dion

Conditions
ConditionsYield
With dmap In pyridine at 0℃; for 2h;99%
With pyridine; dichloromethane
Cortexolone
152-58-9

Cortexolone

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

17α-hydroxy-21-<(methylsulfonyl)oxy>pregn-4-ene-3,20-dione
82427-84-7

17α-hydroxy-21-<(methylsulfonyl)oxy>pregn-4-ene-3,20-dione

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 1h;97%
triethylsilane
617-86-7

triethylsilane

Cortexolone
152-58-9

Cortexolone

17-hydroxy-21-(triethylsiloxy)pregn-4-ene-3,20-dione

17-hydroxy-21-(triethylsiloxy)pregn-4-ene-3,20-dione

Conditions
ConditionsYield
AuCl(xanthphos) In chloroform; N,N-dimethyl-formamide at 50℃; for 6h;96%
Cortexolone
152-58-9

Cortexolone

17,21,21-trihydroxy-4-pregnene-3,20-dione
84869-31-8

17,21,21-trihydroxy-4-pregnene-3,20-dione

Conditions
ConditionsYield
With copper diacetate; air In methanol for 7h; Ambient temperature;95%
Cortexolone
152-58-9

Cortexolone

11β,20-dihydroxy-3-oxo-4,cis-17(20)-pregnadien-21-al
105562-13-8

11β,20-dihydroxy-3-oxo-4,cis-17(20)-pregnadien-21-al

Conditions
ConditionsYield
With oxone; 2-Iodobenzoic acid In dimethyl sulfoxide at 75℃; for 12h; Inert atmosphere;92%
Cortexolone
152-58-9

Cortexolone

20-hydroxy-3,11-dioxo-4,cis-17(20)-pregnadien-21-al
118916-30-6

20-hydroxy-3,11-dioxo-4,cis-17(20)-pregnadien-21-al

Conditions
ConditionsYield
With oxone; 2-Iodobenzoic acid In dimethyl sulfoxide at 75℃; for 12h; Inert atmosphere;92%
Isopropenyl acetate
108-22-5

Isopropenyl acetate

Cortexolone
152-58-9

Cortexolone

cortexolone 21-acetate
640-87-9

cortexolone 21-acetate

Conditions
ConditionsYield
With Rhizopus oryzae lipase immobilized on Lewatit 1600 resin In di-isopropyl ether at 55℃; for 48h; regioselective reaction;91%
Cortexolone
152-58-9

Cortexolone

20-hydroxy-3-oxo-4,cis-17(20)-pregnadien-21-al
118864-85-0

20-hydroxy-3-oxo-4,cis-17(20)-pregnadien-21-al

Conditions
ConditionsYield
With oxone; 2-Iodobenzoic acid In dimethyl sulfoxide at 75℃; for 12h; Inert atmosphere;89%
Cortexolone
152-58-9

Cortexolone

2-Mercaptobenzothiazole
149-30-4

2-Mercaptobenzothiazole

(8R,10R,13S,14S,17R)-17-(2-(benzo[d]thiazol-2-ylthio)acetyl)-17-hydroxy-10,13-dimethyl1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one

(8R,10R,13S,14S,17R)-17-(2-(benzo[d]thiazol-2-ylthio)acetyl)-17-hydroxy-10,13-dimethyl1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one

Conditions
ConditionsYield
With fluorosulfonyl fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 20℃; for 0.166667h;88%
hexanes-ethyl acetate

hexanes-ethyl acetate

Cortexolone
152-58-9

Cortexolone

methyl 17α-hydroxy-3-oxoandrost-4-ene-17-carboxylate
10486-86-9

methyl 17α-hydroxy-3-oxoandrost-4-ene-17-carboxylate

Conditions
ConditionsYield
With sulfuric acid; sodium hydrogencarbonate In methanol87%
Cortexolone
152-58-9

Cortexolone

Androstenedione
63-05-8

Androstenedione

Conditions
ConditionsYield
In water; acetonitrile at 20℃; Electrochemical reaction;86%
With ammonium hydroxide; iodine In water; acetonitrile at 50℃; for 24h;78%
With manganese(IV) oxide In chloroform for 4h; Heating;67.6%
Cortexolone
152-58-9

Cortexolone

Bestmann ylide
73818-55-0, 15596-07-3

Bestmann ylide

4-((8R,9S,10R,13S,14S,17R)-17-Hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-5H-furan-2-one
18104-63-7

4-((8R,9S,10R,13S,14S,17R)-17-Hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-5H-furan-2-one

Conditions
ConditionsYield
In benzene for 3h; Heating;86%
Cortexolone
152-58-9

Cortexolone

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

17α-hydroxy-21-chloro-4-pregnene-3,20-dione
20380-16-9

17α-hydroxy-21-chloro-4-pregnene-3,20-dione

Conditions
ConditionsYield
With dmap In dichloromethane for 4h; Reflux;85%
Cortexolone
152-58-9

Cortexolone

17α-hydroxyandrost-4-en-3-one-17β-carboxylic acid
633-29-4

17α-hydroxyandrost-4-en-3-one-17β-carboxylic acid

Conditions
ConditionsYield
With sodium periodate In tetrahydrofuran; methanol at 20℃; for 2h;82%
With methanol; periodic acid
With periodic acid In methanol
Multi-step reaction with 2 steps
1: TsOH / dioxane; butan-2-one
2: aq. HIO4 / methanol
View Scheme
With sodium hydroxide; sulfuric acid In methanol; water; acetone
phthalimide
136918-14-4

phthalimide

Cortexolone
152-58-9

Cortexolone

2-(2-((8R,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl)isoindoline-1,3-dione

2-(2-((8R,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl)isoindoline-1,3-dione

Conditions
ConditionsYield
With fluorosulfonyl fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 20℃; for 0.166667h;82%
Cortexolone
152-58-9

Cortexolone

A

Progesterone
57-83-0

Progesterone

B

21-Hydroxyprogesterone
64-85-7

21-Hydroxyprogesterone

Conditions
ConditionsYield
With trimethylsilyl iodide In acetonitrile for 3h; Ambient temperature;A 5%
B 72%
With trimethylsilyl iodide In acetonitrile for 3h; Ambient temperature;A 5%
B 72%
With trimethylsilyl iodide In chloroform for 3h; Ambient temperature;A 53%
B 10%
With trimethylsilyl iodide In chloroform for 3h; Ambient temperature;A 38%
B 48%
formaldehyd
50-00-0

formaldehyd

Cortexolone
152-58-9

Cortexolone

17,20:20,21-bismethylenedioxy-4-pregnen-3-one
6173-64-4

17,20:20,21-bismethylenedioxy-4-pregnen-3-one

Conditions
ConditionsYield
With hydrogenchloride In chloroform; water at 20℃; for 5h;71%
With hydrogenchloride; chloroform
Cortexolone
152-58-9

Cortexolone

A

20-hydroxy-3-oxo-4,trans-17(20)-pregnadien-21-al
118864-86-1

20-hydroxy-3-oxo-4,trans-17(20)-pregnadien-21-al

B

20-hydroxy-3-oxo-4,cis-17(20)-pregnadien-21-al
118864-85-0

20-hydroxy-3-oxo-4,cis-17(20)-pregnadien-21-al

Conditions
ConditionsYield
With toluene-4-sulfonic acid In 1,4-dioxane Heating;A 10%
B 71%
With zinc diacetate; acetic acid Heating;A 6%
B 16.6%
With zinc diacetate; acetic acid Heating;A 6%
B 16.6%
Cortexolone
152-58-9

Cortexolone

17α,21-Dihydroxypregn-4-en-3,20-dione 21-phosphate
57099-41-9

17α,21-Dihydroxypregn-4-en-3,20-dione 21-phosphate

Conditions
ConditionsYield
With pyridine; 2-cyanoethyl phosphate; dicyclohexyl-carbodiimide70%
Cortexolone
152-58-9

Cortexolone

2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

17,21-dihydroxy-3-methoxypregna-3,5-dien-20-one 17,21-acetonide
55388-55-1

17,21-dihydroxy-3-methoxypregna-3,5-dien-20-one 17,21-acetonide

Conditions
ConditionsYield
With toluene-4-sulfonic acid In N,N-dimethyl-formamide for 6h; Heating;61%
Cortexolone
152-58-9

Cortexolone

1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester
21085-72-3

1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester

pregn-4-en-17α,21-diol-3,20-dione-21-O-(methyl 2',3',4'-tri-O-acetyl-β-D-glucuronate)
105403-76-7

pregn-4-en-17α,21-diol-3,20-dione-21-O-(methyl 2',3',4'-tri-O-acetyl-β-D-glucuronate)

Conditions
ConditionsYield
With silver carbonate In toluene for 6h; Koenigs-Knorr synthesis; Reflux;48%
Cortexolone
152-58-9

Cortexolone

A

(8R,9S,10R,13S,14S,17R)-17-((R)-1,2-Dihydroxy-ethyl)-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
128-19-8

(8R,9S,10R,13S,14S,17R)-17-((R)-1,2-Dihydroxy-ethyl)-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one

B

4-pregnen-17α,20β,21-triol-3-one
3946-10-9

4-pregnen-17α,20β,21-triol-3-one

Conditions
ConditionsYield
With sodium tetrahydroborate; calcium chloride In water; ethyl acetate at -27℃;A n/a
B 40%

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