1101858-58-5

Basic information

• Product Name: 4-bromo-1-(2-bromoethoxy)-2-nitrobenzene
• Synonyms: 4-bromo-1-(2-bromoethoxy)-2-nitrobenzene
• CAS NO: 1101858-58-5
• Molecular Weight: 324.956
• Mol File: 1101858-58-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-bromo-1-(2-bromoethoxy)-2-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-1-(2-bromoethoxy)-2-nitrobenzene(1101858-58-5)
• EPA Substance Registry System: 4-bromo-1-(2-bromoethoxy)-2-nitrobenzene(1101858-58-5)

Safety Data

• Hazardous Substances Data: 1101858-58-5(Hazardous Substances Data)

Upstream product

• 7693-52-9 4-bromo-2-nitrophenol 
• 106-93-4 ethylene dibromide 

Downstream Products

• 1101858-59-6 4-[2-(4-bromo-2-nitrophenoxy)ethyl]morpholine 
• 1235451-65-6 5-bromo-2-(2-bromoethoxy)benzenamine 

Relevant articles and documents

Dual-target-directed 1,3-diphenylurea derivatives: BACE 1 inhibitor and metal chelator against Alzheimer's disease

Dual-target-directed 1,3-diphenylurea derivatives were designed by hybridizing BACE 1 inhibitor 1 with metal chelator LR-90. A database consisted of 1,3-diphenylurea derivatives was built and screened by the pharmacophore model (Hypo 1) of BACE 1 inhibitor. Based on the predicted results, 11 compounds (6a-d, 9a-g) with favorable Fitvalues were selected, synthesized and evaluated for their BACE 1 inhibitory activities, which showed that the predicted results were in good agreement with the experimental values. Besides, the synthesized compounds also displayed the ability to chelate metal ions. The most effective BACE 1 inhibitor 9f (27.85 ± 2.46 μmol/L) was selected for further receptor-binding studies, the result of which indicated that an essential hydrogen bonds was formed between the urea group of 9f and the catalytic aspartate Asp228.