1103500-32-8Relevant articles and documents
PPARs-FXR multi-target micromolecular agonist as well as preparation method and application thereof
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Paragraph 0092; 0095; 0097; 0143-0148, (2021/05/22)
The invention discloses a PPARs-FXR multi-target micromolecule agonist and a preparation method and application thereof, the structure is shown in a general formula I, and the definition of each substituent group is shown in the description and claims. Th
Isoxazole FXR receptor agonist as well as preparation method and medical application thereof
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, (2021/07/14)
The invention belongs to the field of medicinal chemistry, and particularly relates to an isoxazole FXR receptor agonist and a preparation method and medical application thereof. The invention relates to a compound as shown in a formula (I), and pharmaceutically acceptable salts and isotope markers thereof. The compound as shown in the formula (I), the pharmaceutically acceptable salts and the isotope markers thereof have FXR receptor agonist activity and can be applied to preparation of drugs for treating or preventing hyperlipidemia, atherosclerosis, non-alcoholic steatohepatitis and type II diabetes mellitus.
Isoxazole derivative, pharmaceutical composition containing isoxazole derivative, and preparation method and application thereof
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, (2021/05/19)
The present invention belongs to the field of pharmaceutical chemistry, and generally relates to an isoxazole derivative, and stereoisomers, tautomers, polymorphs, solvates (such as hydrates), esters, metabolites, N-oxides and chemically protected forms and prodrugs thereof, or pharmaceutically acceptable salts thereof. The invention also relates to a preparation method of the compound, a pharmaceutical composition containing the compound and application of the compound and the pharmaceutical composition in treating diseases or conditions mediated by farnesoid X receptor (FXR).