111466-75-2 Usage
Synthetic phospholipid
A type of phospholipid that is artificially synthesized, as opposed to naturally occurring in living organisms.
Derivative of phosphatidylcholine
A chemical compound that is derived from or related to phosphatidylcholine, a major component of cell membranes.
Contains two octanoyl chains
The molecule has two fatty acid chains, specifically octanoyl chains, which are eight-carbon long.
Attached thiophosphate group
The molecule features a thiophosphate group, which is a sulfur-containing analog of a phosphate group, attached to the phospholipid.
Potential therapeutic applications
The compound has been studied for its possible use in treating various medical conditions due to its unique properties.
Used in drug delivery
1,2-dioctanoylthiophosphatidylcholine has been studied for its ability to improve the delivery of drugs, particularly in the context of liposomal formulations.
Enhances delivery and efficacy of anticancer agents
The compound has shown promise in the treatment of cancer by improving the delivery and effectiveness of anticancer drugs.
Anti-inflammatory properties
The compound has demonstrated the ability to reduce inflammation, which could be useful in the development of therapeutic agents for inflammatory conditions.
Antioxidant properties
The compound has shown antioxidant activity, which can help protect cells from damage caused by reactive oxygen species and may be useful in the development of novel therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 111466-75-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,4,6 and 6 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 111466-75:
(8*1)+(7*1)+(6*1)+(5*4)+(4*6)+(3*6)+(2*7)+(1*5)=102
102 % 10 = 2
So 111466-75-2 is a valid CAS Registry Number.
InChI:InChI=1/C24H48NO8P/c1-6-8-10-12-14-16-23(26)30-20-22(33-24(27)17-15-13-11-9-7-2)21-32-34(28,29)31-19-18-25(3,4)5/h22H,6-21H2,1-5H3
111466-75-2Relevant articles and documents
Selective Acylation of Nucleosides, Nucleotides, and Glycerol-3-phosphocholine in Water
Fernández-García, Christian,Powner, Matthew W.
, p. 78 - 83 (2017)
A convenient selective synthesis of 2′,3′-di-O-acetyl-nucleotide-5′-phosphates, 2′,3′-di-O-acetyl-nucleotide-5′-triphosphates and 2′,3′,5′-tri-O-acetyl-nucleosides in water has been developed. Furthermore, a long-chain selective glycerol-3-phosphocholine diacylation is elucidated. These reactions are environmentally benign, rapid, high yielding, and the products are readily purified. Importantly, this reaction may indicate a prebiotically plausible reaction pathway for the selective acylation of key metabolites to facilitate their incorporation into protometabolism.
Stereochemical Analysis of Glycerophospholipids by Vibrational Circular Dichroism
Taniguchi, Tohru,Manai, Daisuke,Shibata, Masataka,Itabashi, Yutaka,Monde, Kenji
supporting information, p. 12191 - 12194 (2015/10/12)
The stereochemistry of glycerophospholipids (GPLs) has been of interest for its roles in the evolution of life and in their biological activity. However, because of their structural complexity, no convenient method to determine their configuration has been reported. In this work, through the first systematic application of vibrational circular dichroism (VCD) spectroscopy to various diacylated GPLs, we have revealed that their chirality can be assigned by the sign of a VCD exciton couplet generated by the interaction of two carbonyl groups. This paper also presents spectroscopic evidence for the stereochemistry of GPLs isolated from bacteria, eukaryotes, and mitochondria.
