111849-29-7

Basic information

• Product Name: 2-AMINO-5-PHENYLTHIOPHENE-3-CARBOHYDRAZIDE
• Synonyms: 2-amino-5-phenyl-3-thiophenecarbohydrazide; 2-Amino-5-phenyl-3-thiophenecarboxylic acid hydrazide; 3-Thiophenecarboxylic acid, 2-amino-5-phenyl-, hydrazide; T5SJ BZ CVMZ ER [WLN]
• CAS NO: 111849-29-7
• Molecular Formula: C₁₁H₁₁N₃OS
• Molecular Weight: 233.29
• Mol File: 111849-29-7.mol

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.34g/cm³
• Refractive Index: 1.683
• CAS DataBase Reference: 2-AMINO-5-PHENYLTHIOPHENE-3-CARBOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-PHENYLTHIOPHENE-3-CARBOHYDRAZIDE(111849-29-7)
• EPA Substance Registry System: 2-AMINO-5-PHENYLTHIOPHENE-3-CARBOHYDRAZIDE(111849-29-7)

Safety Data

• Hazardous Substances Data: 111849-29-7(Hazardous Substances Data)

Usage

Chemical compound

2-AMINO-5-PHENYLTHIOPHENE-3-CARBOHYDRAZIDE

Properties

Heterocyclic compound containing a thiophene ring with an amino group and a carbohydrazide functional group

Applications

Potential applications in pharmaceuticals, agrochemicals, and materials science

Use in organic synthesis

Can be used as a building block in organic synthesis to create compounds with similar structures

Potential biological and chemical activities

Valuable chemical for further research and development

InChI:InChI=1/C11H11N3OS/c12-10-8(11(15)14-13)6-9(16-10)7-4-2-1-3-5-7/h1-6H,12-13H2,(H,14,15)

Upstream product

• 4815-34-3 ethyl 2-amino-5-phenylthiophene-3-carboxylate 

Downstream Products

• 134878-72-1 5-Chloro-10-phenyl-8H-thieno<2',3':4,5>pyrimido<2,1-a>phthalazin-8-one 
• 111849-30-0 3-(Formylamino)-6-phenylthieno<2,3-d>pyrimidin-4(3H)-on 
• 134878-69-6 10-Phenyl-6H-thieno<2',3':4,5>pyrimido<2,1-a>phthalazine-5,8-dione 

Relevant articles and documents

Synthesis and pharmacological evaluation of thieno[2,3-d]pyrimidin-2,4-dione and 5H-pyrimido[5,4-b]indol-2,4-dione derivatives

Two series of novel derivatives based on the thienopyrimidine and pyrimidoindole ring systems, both N-substituted in position 3, have been synthesized. The compounds were obtained by reaction of N-amino groups of 5,6-dimethyl-thieno[2,3-d]pyrimidin-2,4-dione and of 5H-pyrimido[5,4-b]indol-2,4-dione with aromatic aldehydes. Some of these substances showed an appreciable analgesic activity, a good antiinflammatory activity, a low acute toxicity with an optimal gastric tolerance.

Reaction of 2-Thiophenamines with Hydrazine

Depending on their substituents 2-thiophenamines react with hydrazine hydrate on different ways: Hydrazinolysis of the ester 1 yields the 2-amino-3-thiophenecarbohydrazide 2. 4-Phenyl-2-thiophenamine (4) is converted into the 2(5H)-thiophenone hydrazone 5 by exchange of the amino group.The thiophenamines 7, 9, 12 undergo ring transformation to yield pyridazine derivatives, the N,N'-bis(dihydro-3-pyridazinyl)hydrazine 8, the 3-pyridazinylhydrazine 10, and the pyrazolopyridazine 13.From 10 the 1,2,4-triazolopyridazine 11 is obtained.