111992-94-0Relevant articles and documents
A simple and general strategy for the design of fluorescent cation sensor beads
Nath, Suvadeep,Maitra, Uday
, p. 3239 - 3242 (2006)
Chenodeoxycholic acid based PET sensors for alkali metal ions have been immobilized on Merrifield resin and on Tentagel. The fluorescence of the sensor beads is enhanced upon binding the cations. The modular nature of the sensor allows designing different
Synthesis, physicochemical properties, and biological activity of bile acids 3-glucuronides: Novel insights into bile acid signalling and detoxification
Mostarda, Serena,Passeri, Daniela,Carotti, Andrea,Cerra, Bruno,Colliva, Carolina,Benicchi, Tiziana,Macchiarulo, Antonio,Pellicciari, Roberto,Gioiello, Antimo
, p. 349 - 358 (2017/12/28)
Glucuronidation is considered an important detoxification pathway of bile acids especially in cholestatic conditions. Glucuronides are less toxic than the parent free forms and are more easily excreted in urine. However, the pathophysiological significanc
Obeticholic acid structural analogue as well as preparation method and application thereof
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Paragraph 0032; 0033, (2017/08/29)
The invention discloses an obeticholic acid structural analogue. The obeticholic acid structural analogue is 3alpha,7alpha-dihydroxy-23-ethyl-5beta-ursodeoxycholic acid (II). The invention further discloses a preparation method of the obeticholic acid str
Glucuronidation of bile acids under flow conditions: Design of experiments and Koenigs-Knorr reaction optimization
Mostarda, Serena,Filipponi, Paolo,Sardella, Roccaldo,Venturoni, Francesco,Natalini, Benedetto,Pellicciari, Roberto,Gioiello, Antimo
, p. 9592 - 9600 (2015/02/19)
An efficient method for the C3-glucuronidation of bile acids is developed under flow conditions. A modular mesoreactor assisted flow set-up was combined with statistical design of experiments to speed up the optimization of the Koenigs-Knorr re