112064-22-9

Basic information

• Product Name: (2-methylphenyl)(4-pyridinyl)methanol
• Synonyms: (2-methylphenyl)(4-pyridinyl)methanol
• CAS NO: 112064-22-9
• Molecular Formula: C₁₃H₁₃NO
• Molecular Weight: 199.24842
• Mol File: 112064-22-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-methylphenyl)(4-pyridinyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-methylphenyl)(4-pyridinyl)methanol(112064-22-9)
• EPA Substance Registry System: (2-methylphenyl)(4-pyridinyl)methanol(112064-22-9)

Safety Data

• Hazardous Substances Data: 112064-22-9(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry:
(2-methylphenyl)(4-pyridinyl)methanol is used as a synthetic intermediate for the preparation of various organic compounds. Its unique structure allows for a wide range of chemical reactions, making it a valuable building block in organic synthesis.
Used in Pharmaceutical Research:
(2-methylphenyl)(4-pyridinyl)methanol is used as a starting material for the development of new pharmaceutical agents. The combination of the phenyl and pyridinyl groups may impart specific chemical and biological properties, making it a promising candidate for drug discovery.
Used in Medicinal Chemistry:
(2-methylphenyl)(4-pyridinyl)methanol is used as a research tool in medicinal chemistry to explore its potential as a therapeutic agent. Its unique structure and functional groups may contribute to its interaction with biological targets, offering new avenues for drug development.
Used in Drug Discovery:
(2-methylphenyl)(4-pyridinyl)methanol is used in drug discovery efforts to identify novel compounds with potential therapeutic applications. Its unique structure and chemical properties make it an interesting candidate for further investigation and development in the field of medicinal chemistry.

Upstream product

• 100-48-1 pyridine-4-carbonitrile 
• 529-20-4 2-methylphenyl aldehyde 
• 681160-67-8 2-((2-methylbenzyl)oxy)isoindoline-1,3-dione 
• 95-46-5 2-methylphenyl bromide 
• 21656-86-0 4-(2-methylbenzoyl)pyridine 
• 872-85-5 pyridine-4-carbaldehyde 

Downstream Products

• 36995-46-7 4-[(2-methylphenyl)methyl]pyridine 
• 21656-86-0 4-(2-methylbenzoyl)pyridine 
• 496056-24-7 4-(2-methyl-benzyl)-piperidine 

Relevant articles and documents

Reductive arylation of aliphatic and aromatic aldehydes with cyanoarenes by electrolysis for the synthesis of alcohols

An electroreductive arylation reaction of aliphatic and aromatic aldehydes as well as ketones with electro-deficient (hetero)arenes is described. A variety of cyano(hetero)arenes and carbonyl compounds, especially aliphatic aldehydes, have been examined, providing secondary and tertiary alcohols in moderate to good yields. Mechanistic studies, including cyclic voltammetry (CV), electron paramagnetic resonance (EPR), and divided-cell experiments, support the generation of aliphatic ketyl radicals and persistent heteroaryl radical anions via cathodic reduction followed by radical-radical cross-coupling.

Benzylic C-H heteroarylation of: N-(benzyloxy)phthalimides with cyanopyridines enabled by photoredox 1,2-hydrogen atom transfer

A visible light initiated α-C(sp3)-H arylation of N-(benzyloxy)phthalimides with cyanopyridines for the construction of highly valuable pyridinyl-containing diarylmethanols, including bioactive motif-based analogues, is reported. This method enables arylation of the C(sp3)-H bonds adjacent to an oxygen atom through alkoxy radical formation by O-N bond cleavage, 1,2-hydrogen atom transfer (HAT), arylation and C-CN bond cleavage cascades, and offers a means to exploit 1,2-HAT modes to incorporate functional groups for constructing functionalized alcohols.

Bifunctional Oxo-Tethered Ruthenium Complex Catalyzed Asymmetric Transfer Hydrogenation of Aryl N-Heteroaryl Ketones

A facile asymmetric transfer hydrogenation of ortho-substituted aryl N-heteroaryl ketones and non-ortho-substituted N-oxide of aryl N-heteroaryl ketones using a readily available oxo-tethered ruthenium complex as a catalyst and sodium formate as a hydrogen source in an aqueous solution has been discovered. A variety of chiral aryl N-heteroaryl methanols were obtained with up to 99.9% ee.

Amino acid derivatives

Compounds of the Formula I STR1 wherein R1 represents phenyl, or phenyl substituted by one, or more substituents selected from the group consisting of halogen, C1-7 -alkyl, and C1-7 -alkoxy, R2 represents furany

Flexible N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogues: Synthesis and monoamine oxidase catalyzed bioactivation

Eighteen analogues of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were synthesized and evaluated as substrates of monoamine oxidase. In general, the flexible analogues, characterized by the presence of a methylene (or ethylene) bridge between the aryl/heteroaryl and tetrahydropyridyl moieties, were better substrates of the enzyme than the conformationally restricted MPTP. It is suggested that the increased oxidative activity of these flexible analogues reflects enhanced binding due to the ability of the C-4-aryl/heteroaryl substituent to gain access to a hydrophobic pocket within the substrate binding site.