36995-46-7Relevant articles and documents
Synthesis of 4-benzylpyridines via Pd-catalyzed CH3-arylation of 4-picoline
Wu, Jing,Wang, Dadian,Chen, Xiang,Gui, Qingwen,Li, Hua,Tan, Ze,Huang, Genping,Wang, Guangwei
supporting information, p. 7509 - 7512 (2017/09/27)
A highly efficient synthesis of 4-benzylpyridines was developed via Pd-catalyzed C(sp3)-H arylation between 4-picoline and aryl halides. It was found that the best yields were achieved with a simple Pd(PPh3)4 catalyst and Cs2CO3 as the base. Compared with the known methods, our reaction does not require the use of a strong organometallic reagent as the base.
Regioselective synthesis of 4-alkylpyridines from pyridine and aldehydes via dipole reversal process of 1,4-dihydropyridine phosphonate
Lee, Phil Ho,Lee, Kooyeon,Shim, Jun Hwan,Lee, Seong Guk,Kim, Sundae
, p. 777 - 784 (2007/10/03)
4-Alkylation of pyridine has been accomplished by the reaction of ylides, derivated from 1,4-dihydropyridine phosphonate via phosphonioalkoxycarbonylation of pyridine with aldehydes and subsequent elimination of diisopropyl phosphate followed by aromatization with potassium tert-butoxide.
A facile synthesis of functionalized 4-benzylpyridines by using mixed copper, zinc benzylic organometallics
Chia,Shiao
, p. 2033 - 2034 (2007/10/02)
A general approach by use of highly functionalized mixed copper zinc, benzylic organometallics to react with N-ethoxycarbonylpyridinium chloride to give regioselectively 4-benzylpyridines after oxygen oxidation in 30-75% yield is described.
