112259-66-2

Basic information

• Product Name: L-Aspartic acid 4-cyclohexyl ester
• Synonyms: L-ASPARTIC ACID BETA-CYCLOHEXYL ESTER;H-ASP(OCHEX)-OH;H-ASP(OCHX)-OH;H-L-ASP(OCHX)-OH;L-Aspartic acid β-cyclohexyl ester;L-Aspartic acid B-cyclohexyl ester;ASPARTIC ACID-4-CYCLOHEXYL ESTER;H-L-Asp(cHx)-OH
• CAS NO: 112259-66-2
• Molecular Formula: C₁₀H₁₇NO₄
• Molecular Weight: 215.25
• EINECS: 214-359-8
• Product Categories: Amino Acids Derivatives;Amino Acids;Aspartic acid [Asp, D];Amino Acids and Derivatives;Amino ester
• Mol File: 112259-66-2.mol

Chemical Properties

• Boiling Point: 386.2 °C at 760 mmHg
• Flash Point: 187.4 °C
• Appearance: /Solid
• Density: 1.2 g/cm³
• Vapor Pressure: 4.89E-07mmHg at 25°C
• Refractive Index: 1.51
• Storage Temp.: Store at 0°C
• PKA: 2.17±0.23(Predicted)
• CAS DataBase Reference: L-Aspartic acid 4-cyclohexyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Aspartic acid 4-cyclohexyl ester(112259-66-2)
• EPA Substance Registry System: L-Aspartic acid 4-cyclohexyl ester(112259-66-2)

Safety Data

• Hazardous Substances Data: 112259-66-2(Hazardous Substances Data)

Usage

Chemical Properties

White to off white powder

InChI:InChI=1/C10H17NO4/c11-8(10(13)14)6-9(12)15-7-4-2-1-3-5-7/h7-8H,1-6,11H2,(H,13,14)/t8-/m0/s1

Upstream product

• 108-93-0 cyclohexanol 
• 73821-95-1 Boc-Asp(O-cyclohexyl)-OH 
• 56-84-8 L-Aspartic acid 
• 121329-70-2 dicyclohexyl L-aspartate 

Downstream Products

• 134985-89-0 C₁₂H₂₁NO₄ 
• 151012-00-9 N-tritylaspartic acid α-(2-mercaptopyridyl)-β-cyclohexyl diester 
• 191939-65-8 cyclohexyl 3(S)-3-(tritylamino)-4-oxo-6-isopropyloct-7-enoate 
• 191939-66-9 cyclohexyl 3(S)-3-(tritylamino)-4-oxo-6-isopropyloct-7-enoate 
• 191939-67-0 cyclohexyl 3(S)-[(tert-butyloxycarbonyl)amino]-4-oxo-6-isopropyloct-7-enoate 
• 191939-68-1 cyclohexyl 3-[(tert-butyloxycarbonyl)amino]-4-oxo-6-methyl-7-octenoate 
• 151036-42-9 N^α-trityl-L-aspartic acid β-cyclohexyl ester 
• 56-84-8 L-Aspartic acid 
• 73821-95-1 Boc-Asp(O-cyclohexyl)-OH 

Relevant articles and documents

An improved method for the preparation of ω-cyclohexyl esters of aspartic and glutamic acid

An improved synthesis of β-cyclohexyl L-aspartate and γ-cyclohexyl L-glutamate and its N-tert-butoxycarbonyl (Boc) derivatives is described.

Facile synthesis of α-hydroxy carboxylic acids from the corresponding α-amino acids

An effective and improved procedure is developed for the synthesis of α-hydroxy carboxylic acids by treatment of the corresponding protonated α-amino acid with tert-butyl nitrite in 1,4-dioxane-water. The amino moiety must be protonated and located α to a carboxylic acid function in order to undergo initial diazotization and successive hydroxylation, since neither β-amino acids nor acid derivatives such as esters and amides undergo hydroxylations. The method is successfully applied for the synthesis of 18 proteinogenic amino acids.

Cholesterol seco-sterol-induced aggregation of methylated amyloid-β peptides - Insights into aldehyde-initiated fibrillization of amyloid-β

(Chemical Equation Presented) Hot spot on amyloid-β? Atheronal-B-induced aggregation of amyloid-β (Aβ) involves a site-specific adduction of the aldehyde to the ε-amino group of Lys 16, suggesting that Lys 16 is a hot spot for atheronal-induced fibrilliza

Stabilized analogs of thymopentin. 2. 1,2- and 3,4-ketomethylene pseudopeptides

In this second paper in a series of three studies of stable analogs of thymopentin (Arg1-Lys2-Asp3-Val4-Tyr5), the synthesis of analogs stablized at peptide bonds 1,2 and 3,4 via insertion of ketomethylene units is described. A tris(carbobenzyloxy)arginyl(k)norleucine pseudopeptide was synthesized and coupled to Asp-Val-Phe-resin units followed by HF cleavage to prepare Arg(k)Nle-Asp-Val-Phe analogs. Preparation of N-BOC Asp(k)Val and N- BOC Asp(k)Ala units followed by coupling to Phe- or Tyr-resin units provided resin-bound pseudotripeptide substrates for attachment of various arginyl dipeptides. Cleavage from the resin afforded 3,4-ketomethylene-stabilized pseudopeptide analogs of thymopentin. The Arg-Lys-Asp(k)Val-Phe and ArgLys- Asp(k)Val-Tyr analogs were more strongly bound to CEM cells than thymopentin itself. There was significant enhancement of stability in serum for the analogs, especially those containing Arg(k)Nle or Arg-NMeLys moieties at the 1,2-peptide bond.

A Simple and Convenient Synthesis of β-Aspartates and γ-Glutamates

A simple and convenient, high yield synthesis of ω-esters of aspartic as well as glutamic acid has been developed, using tetrafluoroboric acid as catalyst. (13)C-NMR data of the products are given.