112930-58-2 Usage
Uses
Used in Pharmaceutical Industry:
(E)-3-(6,11-Dihydrodibenzo(b,e)thiepin-11-ylidene)propionic acid is used as a pharmacological agent for its potential role in the treatment of psychiatric disorders. Its selective antagonism of dopamine D2 and D3 receptors makes it a valuable compound for the development of new medications aimed at addressing the complex challenges associated with schizophrenia and other related conditions.
Used in Research and Development:
In the field of research and development, (E)-3-(6,11-Dihydrodibenzo(b,e)thiepin-11-ylidene)propionic acid serves as a key compound for studying the mechanisms of action and potential therapeutic effects of dopamine receptor antagonists. Its use in preclinical and clinical studies can provide valuable insights into the development of novel antipsychotic and neuroprotective drugs, ultimately contributing to the advancement of psychiatric treatment options.
Used in Neuroprotection Studies:
(E)-3-(6,11-Dihydrodibenzo(b,e)thiepin-11-ylidene)propionic acid is also used as a research tool in neuroprotection studies. Its potential neuroprotective effects are of interest to scientists seeking to understand and develop treatments for conditions involving neuronal damage or degeneration, such as neurodegenerative diseases or traumatic brain injuries.
Check Digit Verification of cas no
The CAS Registry Mumber 112930-58-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,9,3 and 0 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 112930-58:
(8*1)+(7*1)+(6*2)+(5*9)+(4*3)+(3*0)+(2*5)+(1*8)=102
102 % 10 = 2
So 112930-58-2 is a valid CAS Registry Number.
InChI:InChI=1/C17H14O2S/c18-17(19)10-9-14-13-6-2-1-5-12(13)11-20-16-8-4-3-7-15(14)16/h1-9H,10-11H2,(H,18,19)/b14-9+
112930-58-2Relevant articles and documents
SYNTHESIS OF 3-(6,11-DIHYDRODIBENZOTHIEPIN-11-YLIDENE)-PROPANOIC ACID AND RELATED COMPOUNDS
Polivka, Zdenek,Licha, Irena,Taufmann, Petr,Svatek, Emil,Holubek, Jiri,Protiva, Miroslav
, p. 1566 - 1581 (2007/10/02)
THe alcohol XIa, obtained by reaction of dibenzothiepin-11(6H)-one with vinylmagnesium bromide, was transformed by treatment with hydrogen bromide in acetic acid to the bromo compound XIIa which was converted via the nitrile XIIIa to the title acid VIIIa.The pure (E)-isomer was prepared and correlated via the dimethylamide XVIIIa with (E)-prothiadene (Ia).Similar procedures in the 2-methyl-6,11-dihydrodibenzothiepin and 10,11-dihydrodibenzocycloheptene series afforded the acids VIIIb and IV.The acids VIIIab were oxidized with hydrogen peroxide to the sulfoxides IXab and to the sulfones Xab.The acid IV is the suggested metabolite of the antidepressant amitriptyline (II) and the acids VIIIab-Xab are potential metabolites of the antidepressant prothiadene (Ia) and the antihistamine agent methiadene (Ib).The amides VII and XVIab were prepared from the acids via the acid chlorides.The (Z)-isomer of prothiadene (XXII) was prepared from dibenzothiepin-11(6H)-one by the Wittig reaction.The acids IV, VIIIab and IXab showed some antiinflammatory activity.
