36626-29-6

Basic information

• Product Name: (2-CARBOXYETHYL)TRIPHENYLPHOSPHONIUM CHLORIDE
• Synonyms: (2-CARBOXYETHYL)TRIPHENYLPHOSPHONIUM CHLORIDE;(2-Carboxyethyl)tripheylphosphonium chloride;Nsc165227
• CAS NO: 36626-29-6
• Molecular Formula: C₂₁H₂₀O₂P*Cl
• Molecular Weight: 370.81
• Product Categories: Phosphorylating and Phosphitylating Agents
• Mol File: 36626-29-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 197-201°C
• Appearance: white solid
• Storage Temp.: Refrigerator
• Solubility: Soluble in dimethyl sulfoxide and methanol.
• CAS DataBase Reference: (2-CARBOXYETHYL)TRIPHENYLPHOSPHONIUM CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-CARBOXYETHYL)TRIPHENYLPHOSPHONIUM CHLORIDE(36626-29-6)
• EPA Substance Registry System: (2-CARBOXYETHYL)TRIPHENYLPHOSPHONIUM CHLORIDE(36626-29-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 36626-29-6(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

2-Carboxyethyl)-triphenylphosphonium chloride is a phosphonium ylide reagent for Wittig olefinations with introduction of a carboxylic acid.

InChI:InChI=1/C21H19O2P.ClH/c22-21(23)16-17-24(18-10-4-1-5-11-18,19-12-6-2-7-13-19)20-14-8-3-9-15-20;/h1-15H,16-17H2;1H

Upstream product

• 565-64-0 2,3-dichloropropanoic acid 
• 603-35-0 triphenylphosphine 
• 60633-18-3 (3-carboxy-propyl)triphenylphosphonium chloride 
• 906-65-0 3-(triphenyl-λ-phosphanylidene)dihydrofuran-2,5-dione 

Downstream Products

• 146857-27-4 (E)-4-(3-cyanophenyl)but-3-enoic acid 
• 127404-66-4 (E)-4-(4-fluorophenyl)-3-butenoic acid 
• 98799-43-0 trans-4-(3,4-dimethoxyphenyl)but-3-enoic acid 
• 127404-81-3 (E)-4-(4-(methoxycarbonyl)phenyl)but-3-enoic acid 
• 116237-15-1 (E)-4-((2R,4S,5R)-5-Hydroxy-2-phenyl-[1,3]dioxan-4-yl)-but-3-enoic acid 
• 137744-77-5 (E)-4-(3,4-Dimethoxy-phenyl)-but-3-enoic acid methyl ester 
• 1003580-17-3 6t-phenyl-hexa-3ξ,5-dienoic acid 
• 91083-82-8 (E)-methyl 4-phenylbut-3-enoate 
• 1310810-15-1 methyl (E)-4-(4’-bromophenyl)but-3-enoate 
• 1380511-96-5 (E)-4-(2-bromo-5-methoxyphenyl)-but-3-enoic acid 
• 272456-69-6 (E)-methyl 2-diazo-4-(4-bromophenyl)but-3-enoate 
• 1345876-68-7 (E)-methyl 4-(4-chlorophenyl)-2-diazobut-3-enoate 
• 234084-69-6 (E)-methyl 2-diazo-4-(4-methoxyphenyl)but-3-enoate 
• 1255944-55-8 (E)-4-(2-chlorophenyl)but-3-enoic acid 

Relevant articles and documents

Reaction of 2,3-dihalopropionic acids and their derivatives with P- and N-nucleophiles

3-(Triphenylphosphoniochlorido)acrylic and 2,3-dichloropropionic acids react with triphenylphosphine to form 1,2-bis(triphenylphosphoniochlorido) ethane. Under analogous conditions, 2,3-dibromopropionic acid undergoes debromination followed by triphenylphosphine addition to give, after water treatment, 3-(triphenylphosphoniobromido)propionic acid. 2,3- Dihalopropionitriles react similarly, providing 3-(triphenylphosphoniohalido) propionitriles. The reaction of 2,3-dibromopropionamide with triphenylphosphine was performed to show that E-(triphenylphosphoniobromido)acrylic acid is capable, by contrast to what was reported previously, of reacting with triphenylphosphine. Pyridine forms with 2,3-dihalopropionic acids vinylpyridinium halides, while the reactions with aliphatic amines gives rise to dehydrohalogenation products.

SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS

The present invention provides dibenzoxazepine compounds of Formula I: STR1 which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.