114080-94-3

Basic information

• Product Name: Isoxazolo[5,4-c]pyridin-3-amine (9CI)
• Synonyms: Isoxazolo[5,4-c]pyridin-3-amine;Isoxazolo[5,4-c]pyridin-3-amine (9CI);Isoxazolo[5,4-c]pyridin-3-ylamine
• CAS NO: 114080-94-3
• Molecular Formula: C6H5N3O
• Molecular Weight: 135.1234
• Product Categories: organic building block;PYRIDINE
• Mol File: 114080-94-3.mol

Chemical Properties

• Boiling Point: 361.3°C at 760 mmHg
• Flash Point: 172.3°C
• Appearance: /
• Density: 1.421g/cm³
• Vapor Pressure: 2.1E-05mmHg at 25°C
• Refractive Index: 1.701
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: Isoxazolo[5,4-c]pyridin-3-amine (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Isoxazolo[5,4-c]pyridin-3-amine (9CI)(114080-94-3)
• EPA Substance Registry System: Isoxazolo[5,4-c]pyridin-3-amine (9CI)(114080-94-3)

Safety Data

• Hazardous Substances Data: 114080-94-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
Isoxazolo[5,4-c]pyridin-3-amine (9CI) is utilized as a chemical building block for the development and synthesis of new potential drugs. Its unique molecular structure allows it to interact with biological receptors, which is crucial for the discovery of novel therapeutic agents.
Used in Drug Discovery:
In the drug discovery process, Isoxazolo[5,4-c]pyridin-3-amine (9CI) serves as a key component in the creation of new pharmaceutical compounds. Its ability to bind with biological receptors makes it a promising candidate for the treatment of various diseases and conditions.
Used in Medicinal Chemistry:
Isoxazolo[5,4-c]pyridin-3-amine (9CI) is employed in medicinal chemistry as a structural element in the design of new molecules with potential therapeutic properties. Its compatibility with biological systems and its capacity to engage with receptors are vital for the advancement of medicinal chemistry.
Used in Chemical Synthesis:
Isoxazolo[5,4-c]pyridin-3-amine (9CI) is used in chemical synthesis as a precursor or intermediate in the production of complex organic compounds. Its reactivity and structural features make it a versatile component in the synthesis of a wide range of chemical products.

InChI:InChI=1/C6H5N3O/c7-6-4-1-2-8-3-5(4)10-9-6/h1-3H,(H2,7,9)

Upstream product

• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 113770-88-0 3-fluoro-4-pyridinecarbonitrile 
• 68325-15-5 3-chloro-isonicotinonitrile 
• 546-88-3 acetylhydroxamic acid 

Downstream Products

• 1229383-68-9 isoxazolo[5,4-c]pyridin-3-yl-carbamic acid phenyl ester 
• 1230019-43-8 4-[3-(4-chloro-phenoxy)-benzyl]-piperazine-1-carboxylic acid isoxazolo[5,4-c]pyridin-3-ylamide 

Relevant articles and documents

A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives

A highly efficient and green method has been developed for the rapid preparation of highly functionalized isoxazolopyridin-3-amine derivatives in excellent yields. This process has a broad substrate scope, is operationally simple, and generally requires no chromatographic purification. In addition, the process is scalable and significantly greener than current alternatives with a PMI of 18 and water as the reaction solvent.

Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structure-mutagenicity relationships for arylamine metabolites

The structure-activity relationships for a series of heteroaryl urea inhibitors of fatty acid amide hydrolase (FAAH) are described. Members of this class of inhibitors have been shown to inactivate FAAH by covalent modification of an active site serine with subsequent release of an aromatic amine from the urea electrophile. Systematic Ames II testing guided the optimization of urea substituents by defining the structure-mutagenicity relationships for the released aromatic amine metabolites. Potent FAAH inhibitors were identified having heteroaryl amine leaving groups that were non-mutagenic in the Ames II assay.

SUBSTITUTED 3-AMINOISOXAZOLOPYRIDINES AS KCNQ2/3 MODULATORS

The invention relates to substituted 3-aminoisoxazolopyridines, to processes for their preparation, to medicaments containing these compounds and to the use of these compounds in the preparation of medicaments.

HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE

Certain heteroaryl-substituted piperidinyl and piperazinyl urea compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, insulin resistance, diabetes, osteoporosis, and movement disorders (e.g., multiple sclerosis).

HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE

Certain heteroaryl-substituted piperidinyl and piperazinyl urea compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, insulin resistance, diabetes, osteoporosis, and movement disorders (e.g., multiple sclerosis).