6602-54-6Relevant articles and documents
Preparation method of 2- novel chloronicotinic acid (by machine translation)
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Paragraph 0041-0044, (2020/02/14)
The method disclosed by the invention 2 - comprises the following steps: reacting the obtained :1) product with trichlorooxygen phosphorus, in the presence of 1) an acid, to give 2 - the product of 2 - the present invention ;2) in the following steps: reacting the obtained product with phosphorus oxychloride, in 2 - the presence of a ;3) base with 2) phosphorus oxychloride in the presence of a base, 2 - 2 . (by machine translation)
Environment-friendly preparation method of 2-chloro-3-cyanopyridine
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Paragraph 0021-0064, (2019/03/08)
The invention discloses an environment-friendly preparation method of 2-chloro-3-cyanopyridine. The method comprises the steps of dissolving 3-cyanopyridine N-oxide as a raw material into a certain amount of an organic solvent, adding an additive, organic alkali and a phase transfer catalyst to form a raw material system, controlling to form a proper temperature, dissolving bis(trichloromethyl)carbonate in a certain amount of the organic solvent to obtain a mixture, slowly dropwise adding the mixture into the raw material system for reaction, and after the reaction is finished, carrying out simple treatment, so as to obtain 2-chloro-3-cyanopyridine. The preparation method is simple, the reaction period is short, a phosphorus-containing reagent is replaced with an environment-friendly chlorination reagent, and heavy metals are not adopted; and compared with the prior art, the method has the advantages that the environmental pollution is low, the operation is safe, the cost is low, and the preparation method is suitable for industrial production. The method is applied to the environment-friendly chlorination reaction of 3-cyanopyridine N-oxide and is not limited to the preparation of2-chloro-3-cyanopyridine.
Combining Oxoammonium Cation Mediated Oxidation and Photoredox Catalysis for the Conversion of Aldehydes into Nitriles
Nandi, Jyoti,Witko, Mason L.,Leadbeater, Nicholas E.
supporting information, p. 2185 - 2190 (2018/09/29)
A method to oxidize aromatic aldehydes to nitriles has been developed. It involves a dual catalytic system of 4-acetamido-TEMPO and visible-light photoredox catalysis. The reaction is performed using ammonium persulfate as both the terminal oxidant and nitrogen source.