114990-90-8

Basic information

• Product Name: (S)-GLYCIDIC ACID
• Synonyms: (S)-GLYCIDIC ACID;(2S)-OXIRANE-2-CARBOXYLIC ACID;(S)-oxirane-2-carboxylic acid
• CAS NO: 114990-90-8
• Molecular Formula: C3H4O3
• Molecular Weight: 88.06
• Mol File: 114990-90-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-GLYCIDIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-GLYCIDIC ACID(114990-90-8)
• EPA Substance Registry System: (S)-GLYCIDIC ACID(114990-90-8)

Safety Data

• Hazardous Substances Data: 114990-90-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(S)-GLYCIDIC ACID is used as a chiral building block for the synthesis of pharmaceuticals and other organic compounds. Its unique properties allow for the creation of complex molecules with specific biological activities, making it a valuable asset in drug development.
Used in Polymer Production:
(S)-GLYCIDIC ACID is utilized in the production of polymers, contributing to the development of materials with tailored properties for various applications, such as plastics, coatings, and adhesives.
Used in Organic Synthesis:
(S)-GLYCIDIC ACID serves as a reagent in organic synthesis, enabling the creation of a wide range of chemical compounds for different industries, including the chemical, pharmaceutical, and materials science sectors.

Upstream product

• 57044-25-4 (R)-oxiranemethanol 
• 4538-50-5 methyl (2S)-glycidate 
• 60456-23-7 (S)-oxiranemethanol 
• 145937-64-0 (R)-serine ethyl ester 

Downstream Products

• 7417-65-4 (S)-2-hydroxy-3-(1H-indol-3-yl)-propionic acid 

Relevant articles and documents

EFFICIENT SYNTHESES OF ENANTIOMERICALLY PURE L AND D-ALLOTHREONINES AND (S) AND (R) ISOSERINES

Both enantiomers of (S) 1 and (R) 2 isoserine as well (D) 3 and (L) 4 allothreonine are prepared optically pure in three steps by asymmetric Sharpless epoxidation of crotyl and allylic alcohols into 7-10 followed by an improved RuCl3/NaIO4/water oxidation procedure to low molecular weight glycidic acids 11-14 and epoxide opening by ammonia with (20-33 percent) overall yields.

Nonracemic 2-diazo-1-oxiranyl-ethanone, a versatile chiral epoxide educt in diazocarbonyl reactions

(equation presented) (S)-(-)-2-Diazo-1-oxiranyl-ethanone, prepared in two steps from (R)-(+)-glycidol, has been employed as an intermediate in several characteristic diazocarbonyl reactions to yield novel, nonracemic products including an epoxy quinoxaline and epoxy thiazoles and oxazoles.

SARS-COV-2 INHIBITORS HAVING COVALENT MODIFICATIONS FOR TREATING CORONAVIRUS INFECTIONS

Provided herein are compounds, pharmaceutical compositions and methods for treating a SARS-CoV-2 infection.

INTERMEDIATES AND METHODS FOR THE PREPARATION OF EPOTHILONES

Highly efficient methods are provided for preparing key intermediates in the synthesis of epothilones and use new alane reagents which are broadly applicable and can provide selected components having a variety of substituents groups.

Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin

A series of hybrid compounds of bestatin (1) and actinonin (3), which promote degradation of cellular inhibitor of apoptosis protein 1 (cIAP1), were designed and synthesized. Structure-activity relationship studies indicated that absolute configuration, hydrophobicity at the α-position of the internal amide carbonyl group, and the presence of a small substituent at the α-position of the ester group are important factors for the expression of potent cIAP1 degradation-promoting activity. HAB-5A (30b) showed the most potent activity (IC50 = 0.53 μM) among the compounds prepared.